REACH: Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Study Details
Study Description
Brief Summary
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
It is our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance. Data from our two research teams suggest that the cardiac and skeletal muscle microvascular dysfunction present in people with type 2 diabetes contributes to limitations in cardiac and skeletal muscle function associated with impaired functional exercise capacity (a major predictor of CV and all-cause mortality). Insulin action is a potent predictor of the functional exercise capacity impairment in type 2 diabetes. The exact relationship between insulin action, cardiac and muscle dysfunction, cardiac and skeletal muscle perfusion and decreased functional exercise capacity in type 2 diabetes remains unclear.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Type 2 Diabetes Participants aged 30-55 with type 2 diabetes |
Behavioral: Cardiovascular exercise
15 weeks of cardiovascular exercise 3x/week for 50 minutes/session
|
Experimental: Healthy overweight control Participants aged 30-55 with BMI 25-40 without type 2 diabetes |
Behavioral: Cardiovascular exercise
15 weeks of cardiovascular exercise 3x/week for 50 minutes/session
|
Outcome Measures
Primary Outcome Measures
- Change in peak oxygen consumption (VO2) [Through study completion, approximately 4 months]
Subjects' peak oxygen consumption will be tested on a stationary bike before and after 15 weeks of exercise
- Change in insulin sensitivity [Through study completion, approximately 4 months]
The investigators will evaluate the changes in insulin sensitivity utilizing a euglycemic insulin clamp
Eligibility Criteria
Criteria
Inclusion Criteria:
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Sedentary (defined as less than 1 hour per week of physical activity)
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BMI: 25-40
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Men and women with and without type 2 diabetes
Exclusion Criteria:
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Documented cardiovascular disease
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Uncontrolled hypertension: disease systolic blood pressure (SBP) > 150, diastolic blood pressure (DBP)> 110
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Obstructive pulmonary disease or asthma
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Peripheral neuropathy
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Physical impairment that would limit exercise ability
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Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
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Current or past smoking within the last 1 years
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Current tobacco use
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Anemia
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Control HbA1c > 5.7, T2DM HbA1c > 9
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Pregnant, nursing or hormonal therapy (other than contraceptives)
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Peri or post-menopausal women
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Type 1 diabetes
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Hepatic or renal disease.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Colorado | Aurora | Colorado | United States | 80045 |
2 | University of Virginia | Charlottesville | Virginia | United States | 22908 |
Sponsors and Collaborators
- University of Colorado, Denver
- University of Virginia
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20-2723
- R01DK124344