UHSM CMR: The UHSM Cardiovascular Magnetic Resonance Study
This study aims to investigate the diagnostic and prognostic utility of cardiovascular magnetic resonance (CMR) imaging in a large cohort of unselected patients who are undergoing CMR scanning for clinical indications (i.e. suspected/confirmed cardiovascular disease). CMR indices will be related to the presence and severity of cardiovascular disease and other markers of cardiovascular and health status.
|Condition or Disease||Intervention/Treatment||Phase|
Patients will undergo CMR scanning in the usual clinical manner. As part of the study, patients will undergo approximately 5 minutes of extra CMR scanning. Cardiovascular anatomical, structural and functional data will be recorded, including data pertaining to myocardial characteristics (e.g. extracellular volume, oedema, fibrosis, infarction, function, perfusion), pericardial disease; valvular disease; vascular structure and function.
Blood sampling will be performed on the same day as CMR scanning for assessment of serum/plasma markers of cardiovascular disease and health status, and DNA analysis. Health questionnaires will be completed on the day of CMR scanning.
Follow-up information regarding health status, demographics and concurrent medical conditions and treatments will be obtained over a 10 year period following CMR scanning.
Primary Outcome Measures
- All cause mortality [10 years with planned interim analyses]
Secondary Outcome Measures
- Cardiovascular death [10 years with planned interim analyses]
- Hospitalisation for heart failure [10 years with planned interim analyses]
- Development of cardiovascular disease [10 years with planned interim analyses]
- Development of complications of cardiovascular disease [10 years with planned interim analyses]
Any adult patient undergoing clinically indicated CMR scanning at the UHSM CMR Unit.
Age < 18 years, imprisonment, inability to provide informed consent.
Contacts and Locations
|1||University Hospital of South Manchester||Manchester||Greater Manchester||United Kingdom||M23 9LT|
Sponsors and Collaborators
- Manchester University NHS Foundation Trust
- University of Pittsburgh Medical Center
- Principal Investigator: Christopher A Miller, MBChB, PhD, University Hospital of South Manchester
- Principal Investigator: Matthias Schmitt, MD, PhD, University Hospital of South Manchester
Study Documents (Full-Text)None provided.