Utilizing Smart Devices to Identify New Phenotypical Characteristics in Movement Disorders
Study Details
Study Description
Brief Summary
This observational and experimental study seeks to establish a Smart Device System (SDS) to monitor high-resolution handtremor-based data using Smartphones, SmartWatches and Tablets. By doing this, movement data will be analyzed in depth with advanced statistical and Deep-Learning algorithms to identify new clinical phenotypical characteristics Parkinson's Disease and Essential Tremor.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Current smart devices as smartphones and smartwatches have reached a level of technical sophistication that enables high-resolution monitoring of movements not only for everyday sports activities but also for movement disorders. Tremor-related diseases as Parkinson's Disease (PD) and Essential Tremor (ET) are two of the most common movement disorders. Disease classification is primarily based on clinical criteria and remains challenging. The primary goal of this study is to identify new phenotypical characteristics based on the captured movement data by the tremor-capturing smartwatches and tablets and smartphone-based questionnaires.
The system will be applied and analyzed within an experimental and observational setting and only captures from patients, which have received informed consent. Within the study period, the SDS is not intended as clinical diagnostic support for physicians and will be not be used as medical device.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Parkinson's Disease Participant's diagnosed with Parkinson's Disease |
Other: Data Capture
This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.
|
| Essential Tremor Participant's diagnosed with Essential Tremor or other Movement Disorders |
Other: Data Capture
This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.
|
| No Parkinson's Disease and No Essential Tremor Participant's with no diagnosis of PD, ET or other Movement Disorders |
Other: Data Capture
This is no intervention. Participants of all groups will receive data Capture with smartphones, smartwatches and tablets.
|
Outcome Measures
Primary Outcome Measures
- Acceleration data in all three axes (x,y,z) measured at both wrists via Smartwatches during 10 minutes of neurological examination. Aggregated data: Mean Frequency and Amplitude of Tremor. [2018-2020]
The raw time series data (acceleration data) and the aggregated data will be analyzed to train a neural network to classify the participant's movement disorder.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnosed with Parkinson's Disease (ICD-10-GM G20.-) or Essential Tremor (G25.0)
-
Comparison group: Other movement disorders including atypical Parkinsonian disorders and healthy participants
Exclusion Criteria:
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Unable to obtain informed consent
-
Skin-related conditions at one of the wrists or any other medical conditions that could harm the participant's health by wearing the smartwatch at both wrists.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Institute of Medical Informatics, University of Münster | Münster | Germany | 48149 |
Sponsors and Collaborators
- Westfälische Wilhelms-Universität Münster
Investigators
- Principal Investigator: Julian Varghese, MD, WWU Münster, Institut für Medizinische Informatik
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- VA111809