VALID: Vienna Vascular Liver Disease Study
Study Details
Study Description
Brief Summary
The aim of this Register Trial is to systematically study the epidemiology, risk factors, liver function as well prognosis of patients with vascular liver diseases. Furthermore, important clinical parameters will be assessed in order to evaluate patients' coagulation status and in order to develop new biomarkers derived from blood, urine, stool or ascites of patients as well as histological samples from the upper / lower GI-tract or the liver in order to better understand the natural history of vascular liver diseases.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
We will include patients with vascular liver diseases, including
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portal vein thrombosis (PVT)
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Budd-Chiari Syndrome (BCS)
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Heredetary Hemorrhagic Teleangiectasia (HHT, or Osler-Rendu Disease)
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Noncirrhotic-portal hypertension (NCPH)
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Cirrhosis cardiaque if the fulfill inclusion/exclusion criteria and provide written informed consent. Participation in the biobank is optional for the patients. In particular, we will study the natural course of the patients in regard to hepatic decompensation (ascites, variceal bleeding, hepatic encephalopathy), need for intensified treatment (TIPS, ICU, liver transplantation) and survival.
Study Design
Outcome Measures
Primary Outcome Measures
- Hepatic Decompensation [Up to 10 years (=Study Period)]
Any first hepatic decompensation: variceal bleeding, new onset of ascites, new onset of hepatic encephalopathy, new onset of jaundice
Secondary Outcome Measures
- Liver-related death [Up to 10 years (=Study Period)]
Death from a liver-related cause
- Coagulation status [Up to 10 years (=Study Period)]
Coagulation status of the Patient as assessed by advanced coagulation tests (including TEG-ROTEM and TGA)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Diagnosis of a vascular liver disease by imaging (sonography, CT, MRI), transient elastography or liver histology
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PVT: Portal vein thrombosis
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NCPH: non-cirrhotic Portal Hypertension
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BCS: Budd-Chiari-Syndrome
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SOS: sinusoidal occlusive disease
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HHT: hereditary hemorrhagic teleangiectasia
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CIRCAD: cirrhosis cardiaque
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Age >18 years and <100 years
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Written informed consent obtained
Exclusion Criteria:
- withdrawal of written informed consent
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Medical University of Vienna | Vienna | Austria | 1090 |
Sponsors and Collaborators
- Medical University of Vienna
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- VALID 1928/2017