VCRC Tissue Repository

Study Details

Study Description

Brief Summary

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Condition or Disease	Intervention/Treatment	Phase
Aortitis Cutaneous Vasculitis Eosinophilic Granulomatosis With Polyangiitis Giant Cell Arteritis Granulomatosis With Polyangiitis (Wegener's) Henoch-Schonlein Purpura IgA Vasculitis Microscopic Polyangiitis Polyarteritis Nodosa Takayasu Arteritis Churg-Strauss Syndrome

Detailed Description

Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Study Design

Study Type:

Observational

Anticipated Enrollment :

1000 participants

Observational Model:

Cohort

Time Perspective:

Other

Official Title:

VCRC Tissue Biorepository Collection Protocol

Actual Study Start Date :

Nov 1, 2016

Anticipated Primary Completion Date :

Sep 1, 2022

Anticipated Study Completion Date :

Sep 1, 2022

Outcome Measures

Primary Outcome Measures

Identify genes that increase the risk of developing vasculitis [1 year]
Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis.

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion Criteria:

Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
Unwilling to allow the use of their tissue for research.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Brigham and Women's Hospital	Boston	Massachusetts	United States	02115
2	Boston University School of Medicine	Boston	Massachusetts	United States	02118
3	Cleveland Clinic	Cleveland	Ohio	United States	44195
4	University of Pennsylvania	Philadelphia	Pennsylvania	United States	19104
5	University of Pittsburgh	Pittsburgh	Pennsylvania	United States	15261
6	University of Utah	Salt Lake City	Utah	United States	84132
7	St. Joseph's Healthcare	Hamilton	Ontario	Canada	L8N 3B6
8	University of Toronto Mount Sinai Hospital	Toronto	Ontario	Canada	M5G 1X5