Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation
Study Details
Study Description
Brief Summary
Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
A Patients with moderate-to-severe aortic regurgitation having normal left ventricular ejection fraction |
|
B Age, sex and bodymass index matched healthy subjects |
Outcome Measures
Primary Outcome Measures
- Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates [April 2008]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Moderate-to-severe aortic regurgitation identified by Standard echocardiography.
-
Chronic isolated aortic regurgitation
-
Being asymptomatic ( Class 1 according to NYHA)
-
Sinusal rhythm
Exclusion Criteria:
-
Ejection fraction < 50%
-
Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis
-
Aortic stenosis
-
Previous myocardial infarction, or the patients with >50% coronary occlusion in any of the coronary arteries.
-
Cardiomyopathies
-
AV conduction disorders
-
Chronic renal or hepatic insufficiency
-
Malignities
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology | Istanbul | Sisli | Turkey | 34381 |
Sponsors and Collaborators
- Florence Nightingale Hospital, Istanbul
Investigators
- Principal Investigator: Saide Aytekin, Professor, T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology
Study Documents (Full-Text)
None provided.More Information
Publications
- YT1977