Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Study Details
Study Description
Brief Summary
Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Early Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Stellate ganglion block All subjects will undergo stellate ganglion block during their VT ablation procedure |
Drug: Stellate Ganglion Block
Left sided percutaneous stellate ganglion block
|
Outcome Measures
Primary Outcome Measures
- Ventricular Effective Refractory Period [30 minutes following stellate ganglion block]
Change in Ventricular Effective Refractory Period at 600ms drive train (measured in milliseconds)
Secondary Outcome Measures
- Ventricular Arrhythmia Inducibility [30 minutes following stellate ganglion block]
Induction of monomorphic ventricular arrhythmia (binary outcome) during ventricular programmed stimulation
- Neuropeptide Y [30 minutes following stellate ganglion block]
Change in level of neuropeptide Y from baseline (measured in pg/mL)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Planned catheter based VT ablation
-
Age at least 18 years
Exclusion Criteria:
-
Pregnancy
-
Contraindication to SGB or VT ablation
-
Hypersensitivity of local anesthetic of amide type
-
Hemodynamic instability during the procedure prior to the study protocol
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Pennsylvania
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 851066