VICTOIRE: VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
Study Details
Study Description
Brief Summary
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients for whom there is no planned implant surgery
|
Device: IRMf-r (séquence resting state)
Functional MRI of functional brain networks
|
| Patients for whom implantation surgery is planned
|
Device: IRMf-r (séquence resting state)
Functional MRI of functional brain networks
|
| case
|
Device: IRMf-r (séquence resting state)
Functional MRI of functional brain networks
|
Outcome Measures
Primary Outcome Measures
- Localization and characterization of neural networks [baseline]
neuronal networks description using rest and morphological functionnal MRIs
- Evolution of neuronal networks after retinal implantation [baseline]
neuronal networks description using rest and morphological functionnal MRIs
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patient over 18 years old
-
Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
-
Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
-
Express consent to participate in the study
-
Affiliate or beneficiary of a social security scheme
Exclusion Criteria:
-
Patient benefiting from a legal protection measure
-
Pregnant or breastfeeding woman
-
Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
-
Other additional ocular pathology that can significantly affect vision
-
Recent eye surgery less than 3 months old
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fondation Adolphe de Rothschild | Paris | France | 75019 |
Sponsors and Collaborators
- Fondation Ophtalmologique Adolphe de Rothschild
Investigators
- Principal Investigator: Augustin LECLER, Fondation Ophtalmologique A. de Rothschild
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ALR_2020_30