Pupillometry and Locus Coeruleus Activation (PuLCA)
Study Details
Study Description
Brief Summary
This project will apply non-invasive, trans-cutaneous vagal nerve stimulation using various stimulation parameters to young, healthy adults to find the optimal set of parameters to elicit pupil response.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Group A: Experimental Within-subjects design with a randomization of the order of tVNS administered parameters |
Device: transcutaneous electrical nerve stimulation devices
electrical stimulation through surface electrodes
Other Names:
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Active Comparator: Group B: Active Comparator Within-subjects design with a randomization of the order of tVNS administered parameters |
Device: transcutaneous electrical nerve stimulation devices
electrical stimulation through surface electrodes
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Ocular response after transcutaneous nerve stimulation [Visit 1 day]
Number of participants with pupil response after transcutaneous nerve stimulation
Eligibility Criteria
Criteria
Inclusion Criteria:
- Fluent English speaker with reading and writing proficiency.
Exclusion Criteria:
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Participants with significant visual impairment or ocular illness may be excluded at the discretion of the principal investigator.
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Major medical illnesses including severe neurological illness (e.g. stroke, seizure history), autoimmune disorders, and severe psychiatric diseases (e.g., schizophrenia)
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Any history of brain surgery, tumor, intracranial metal implantation, pacemakers, or other implanted devices.
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Current (i.e. within 48 hours of the session) prescription medication or over-the-counter medication use.
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Illicit alcohol or drug use. Caffeine (e.g, coffee, energy drinks) consumption prior to the visit.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Florida | Gainesville | Florida | United States | 32610 |
Sponsors and Collaborators
- University of Florida
Investigators
- Principal Investigator: Eric Porges, PhD, University of Florida
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB201903471