WTC Chest CT Imaging Archive
Study Details
Study Description
Brief Summary
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai Medical Center between 2003 and 2016. The clinical team sought to assess all findings suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate those findings with clinical, functional, and exposure indicators. The study team's research will also involve analyses of longitudinal imaging and functional trends, and characterization of the WTC related lower airway diseases and their risk factors, with a focus on obesity-related imaging markers. The study team also plans to characterize the transitions into chronic obstructive pulmonary disease (COPD) among these workers.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The goal of this proposal is to characterize WTC-related lower airway disorders, and use novel imaging approaches to the investigation of obesity, one of their most important risk factors for poor clinical outcome and chronicity. To that end, the clinical team will utilize the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, an already established large imaging database, linked to extensive related databases that include disease symptoms, both pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal spirometry measurements, visual imaging classification and grading, and quantitative computer assisted method (QCAM) measurements of airway, pulmonary parenchymal, pleural, and cardiovascular abnormalities. During the course of the proposed research project, the clinical team will continue to enrich most sources of data with periodic updates, in order to accrue information on the trajectories of the different clinical, functional, and imaging abnormalities observed in this population, and investigate the role of key adverse risk factors directly, and in collaboration with other investigators. In a related project, the research team will focus on COPD, classifying its severity, investigating its diagnostic stability, progression, and transitions, characterize structural abnormalities as assessed by chest CT imaging, and examine the interaction of WTC-related exposure levels with tobacco smoking on increasing the risk of for the disease.
Study Design
Outcome Measures
Primary Outcome Measures
- Accelerated longitudinal FEV1 decline [5 years]
The clinical team selects spirometries of acceptable quality, and subjects with at least 3 spirometries spanning at least 5 years, to calculate FEV1 slope, which can then be modeled quantitatively. For categorical analyses, the clinical team defines rapid FEV1 decliners and contrast them to normal-and-stable FEV1 subjects, defined as those having an FEV1 above the lower limit of normal at baseline, no bronchodilator response, and FEV1 not changing by more than 25 ml/year on average in either direction.
Secondary Outcome Measures
- Number of physician diagnosis of incident asthma [5 years]
Physician diagnosis of asthma with onset after WTC occupational exposures.
Eligibility Criteria
Criteria
Inclusion Criteria:
- All subjects will be participants in the screening/monitoring (SMP) and treatment program (TP) sides of the WTC Health Plan Clinical Center Excellence at Mount Sinai Medical Center, the major site, by far of the NY/NJ consortium of this program.
Exclusion Criteria:
- Special vulnerable populations, such as fetuses, neonates, pregnant women, children, prisoners, institutionalized individuals, will not be involved in this research study.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Icahn School of Medicine at Mount Sinai | New York | New York | United States | 10029 |
Sponsors and Collaborators
- Icahn School of Medicine at Mount Sinai
- University of Pittsburgh
- Brigham and Women's Hospital
- National Jewish Health
- University of New Mexico
Investigators
- Principal Investigator: Rafael E. de la Hoz, MD, MPH, MSc, Icahn School of Medicine at Mount Sinai
Study Documents (Full-Text)
None provided.More Information
Additional Information:
- CDC/NIOSH Project Profile
- CDC/NIOSH Project Profile
- Principal investigator's academic web page
- Principal investigator's ORCID record
- CDC/NIOSH Project Profile
- PrincipaI investigator's WTC-related bibliography
Publications
- Brite J, Friedman S, de la Hoz RE, Reibman J, Cone J. Mental health, long-term medication adherence, and the control of asthma symptoms among persons exposed to the WTC 9/11 disaster. J Asthma. 2020 Nov;57(11):1253-1262. doi: 10.1080/02770903.2019.1672722. Epub 2019 Oct 10.
- de la Hoz RE, Christie J, Teamer JA, Bienenfeld LA, Afilaka AA, Crane M, Levin SM, Herbert R. Reflux symptoms and disorders and pulmonary disease in former World Trade Center rescue and recovery workers and volunteers. J Occup Environ Med. 2008 Dec;50(12):1351-4. doi: 10.1097/JOM.0b013e3181845f9b. Erratum in: J Occup Environ Med. 2009 Apr;51(4):509.
- de la Hoz RE, Hill S, Chasan R, Bienenfeld LA, Afilaka AA, Wilk-Rivard E, Herbert R. Health care and social issues of immigrant rescue and recovery workers at the World Trade Center site. J Occup Environ Med. 2008 Dec;50(12):1329-34. doi: 10.1097/JOM.0b013e31818ff6fd.
- de la Hoz RE, Shohet MR, Chasan R, Bienenfeld LA, Afilaka AA, Levin SM, Herbert R. Occupational toxicant inhalation injury: the World Trade Center (WTC) experience. Int Arch Occup Environ Health. 2008 Feb;81(4):479-85. Epub 2007 Sep 5.
- de la Hoz RE, Weissman DN. Consideration of Occupational and Environmental Lung Carcinogen Exposures for Lung Cancer Screening Using Low-Dose Chest CT. Chest. 2018 Oct;154(4):996-997. doi: 10.1016/j.chest.2018.07.023.
- de la Hoz RE. Occupational lower airway disease in relation to World Trade Center inhalation exposure. Curr Opin Allergy Clin Immunol. 2011 Apr;11(2):97-102. doi: 10.1097/ACI.0b013e3283449063. Review.
- Mendelson DS, Roggeveen M, Levin SM, Herbert R, de la Hoz RE. Air trapping detected on end-expiratory high-resolution computed tomography in symptomatic World Trade Center rescue and recovery workers. J Occup Environ Med. 2007 Aug;49(8):840-5.
- GCO 12-0751
- U01OH010401
- U01OH011697
- GCO 17-2598