The Yield of Postnatal Thyroid Function Test in the Well Baby Nursery
Study Details
Study Description
Brief Summary
Thyroid function test are performed in the well baby nursery to newborn infants of mothers with hypothyroidism, or as part of neonatal jaundice investigation. As thyroid function test are also part of the national screening test program, the investigators raised the option that the above management is unnecessary, and managed a study to investigate it.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Thyroid function test are performed in the well baby nursery to newborn infants of mothers with hypothyroidism, or as part of neonatal jaundice investigation. As thyroid function test are also part of the national screening test program, the investigators raised the option that the above management is unnecessary, and managed a study to investigate it.
The study is retrospective. About 4000 infants are born in the center every year. The investigators wish to examine data for 10 years, i.e. about 40000 files.
The investigators will collect all the national screening test program results and compare them to the thyroid function test performed in that center.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Newborn infants Newborn infants born in our medical center |
Diagnostic Test: Thyroid function test
Thyroid function test
|
Outcome Measures
Primary Outcome Measures
- Hypothyroidism found in local test was missing by national screening test [10 years]
The proportion of missed hypothyroidism in screening test (missing = found in local test and missed in national screening test)
- Hypothyroidism found in screening test was missing in local test [10 years]
The proportion of missed hypothyroidism in local test (missing = found in national screening test and missed in local test)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Infants born in our medical center
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Term infants
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Admitted to well baby nursery and stayed there until discharge
Exclusion Criteria:
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Preterm infants
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Transferred to neonatal intensive care unit for any reason
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Hillel Yaffe medical center | H̱adera | Hadera | Israel | 38100 |
Sponsors and Collaborators
- Hillel Yaffe Medical Center
Investigators
- Principal Investigator: Erez Nadir, MD, Hillel Yaffe Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017 Mar;27(3):315-389. doi: 10.1089/thy.2016.0457. Erratum in: Thyroid. 2017 Sep;27(9):1212.
- American Academy of Pediatrics, Rose SR; Section on Endocrinology and Committee on Genetics, American Thyroid Association, Brown RS; Public Health Committee, Lawson Wilkins Pediatric Endocrine Society, Foley T, Kaplowitz PB, Kaye CI, Sundararajan S, Varma SK. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics. 2006 Jun;117(6):2290-303. Review.
- van Trotsenburg P, Stoupa A, Léger J, Rohrer T, Peters C, Fugazzola L, Cassio A, Heinrichs C, Beauloye V, Pohlenz J, Rodien P, Coutant R, Szinnai G, Murray P, Bartés B, Luton D, Salerno M, de Sanctis L, Vigone M, Krude H, Persani L, Polak M. Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology. Thyroid. 2021 Mar;31(3):387-419. doi: 10.1089/thy.2020.0333. Review.
- 0128-21-HYMC-IL