CUPCAKE: Fitness Assessment in Young Adults Recovered From Lymphoma
Study Details
Study Description
Brief Summary
Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.
Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.
Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .
The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Healthy controls sex and age matched healthy controls |
Other: Indirect calorimetric test during submaximal exercise
metabolic evaluation by indirect calorimetry at rest and during exercise
evaluation of cardiac output
peripheral quantitative computed tomography (pQCT) of the muscle cross section
evaluation of body composition
assessment of physical capacity (chair test and 3 min step-test)
blood test
assess the level of physical activity
Other Names:
|
| Experimental: young adults recovered from lymphoma or Hodgkin's disease young adults recovered from lymphoma or Hodgkin's disease |
Other: Indirect calorimetric test during submaximal exercise
metabolic evaluation by indirect calorimetry at rest and during exercise
evaluation of cardiac output
peripheral quantitative computed tomography (pQCT) of the muscle cross section
evaluation of body composition
assessment of physical capacity (chair test and 3 min step-test)
blood test
assess the level of physical activity
Other Names:
|
Outcome Measures
Primary Outcome Measures
- fat oxidation rate [day at 11:30 am during one day]
maximum rate of lipid oxidation (in mg/ml)
Secondary Outcome Measures
- rest metabolism [at 08:00 am in fasted condition during one day]
energy expenditure at rest in kcal.
- blood insulinemia [at 07:30 am in fasted condition during one day]
blood value of insulin in pmol/L
- blood N-terminal pro-B natriuretic peptide [at 07:30 am in fasted condition during one day]
blood N-terminal pro-B natriuretic peptide level in g/L
- blood troponin [at 07:30 am in fasted condition during one day]
blood troponin level in g/L
- blood lipids [at 07:30 am in fasted condition during one day]
blood lipids level in g/L
- blood glucose [at 07:30 am in fasted condition during one day]
blood glucose level in g/L
- Body composition: fat [at 07:30 am during one day]
percentage of fat
- Body composition: lean mass [at 07:30 am during one day]
percentage of lean mass
- cardiac output [at 11:30 am during one day]
Systolic Ejection Volume in mL evaluated at rest and during submaximal exercise
- peripheral quantitative computed tomography [at 10:45 am during one day]
Cross-sectional area of thigh muscles and intermuscular adipose tissue were assessed for muscle at 40% of the length between the greater trochanter and the mid-patella of the right leg
- physical condition [at 08:45 am during one day]
3 min step-test (number of ascent / descent step)
- physical capacity [at 08:45 am during one day]
chair test (time in second held in position)
- physical activity level [from day 2 to day 5]
daily energy expenditure (in Kcal)
- sedentary level [from day 2 to day 5]
total sedentary time (in min) evaluated by accelerometer for 4 days
Eligibility Criteria
Criteria
Inclusion Criteria:
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Young adult male or female, aged 18 to 25
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giving free and informed consent
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Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
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Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease
Exclusion Criteria:
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Legal incapable adults
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People under judicial protection
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Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
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Medical contraindication to the practice of physical exercise
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Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
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Any treatment that may have an influence on the energy metabolism
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Active infection
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Pregnant, breastfeeding, or likely to be
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Subject's refusal to participate
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHU de Clermont-Ferrand | Clermont-Ferrand | France | 63000 |
Sponsors and Collaborators
- University Hospital, Clermont-Ferrand
Investigators
- Principal Investigator: Justina Kanold, University Hospital, Clermont-Ferrand
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RBHP 2021 KANOLD
- 2021-A02184-37