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Showing 1 - 25 of
7,015 items
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LAST UPDATED
H
Phase II Hedgehog Inhibitor for Myelodysplastic Syndrome (MDS) - 2021
Completed
Has Results
  • Myelodysplastic Syndrome (MDS)
  • Chronic Myelomonocytic Leukemia (CMML)
  • Tampa, Florida
    H. Lee Moffitt Cancer Center and Research Institute
2021-06-10
Jun 10, 2021
R
Anti-PD1-antibody and Pulsed HHI for Advanced BCC
Recruiting
  • Basal Cell Carcinoma
  • Cemiplimab Injection [Libtayo]
  • Zürich, Switzerland
    University Hospital Zurich, Clinic of Dermatology
2021-03-17
Mar 17, 2021
U
PF-04449913 For Patients With Acute Myeloid Leukemia at High Risk of Relapse After Donor Stem Cell Transplant - 2020
Completed
Has Results
  • Adult Acute Myeloid Leukemia in Remission
  • Recurrent Adult Acute Myeloid Leukemia
  • Aurora, Colorado
  • +1 more
2021-12-30
Dec 30, 2021
N
Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancer
Recruiting
  • Pancreatic Ductal Adenocarcinoma
  • Málaga, Andalucía, Spain
  • +3 more
2022-02-25
Feb 25, 2022
U
To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) - 2014
Completed
Has Results
  • Basal Cell Nevus Syndrome
  • Gorlin Syndrome
  • Oakland, California
  • +1 more
2020-12-16
Dec 16, 2020
A
Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor
Recruiting
  • Basal Cell Carcinoma
  • Basal Cell Nevus Syndrome
  • ASN-002
  • Brisbane, Queensland, Australia
  • +5 more
2022-02-10
Feb 10, 2022
G
Glasdegib in Refractory Patients With Sclerotic Chronic Graft-Versus-Host Disease
Active, not recruiting
  • Sclerodermoid Chronic Graft-Versus-Host Disease (Disorder)
  • Barcelona, Spain
  • +5 more
2022-03-16
Mar 16, 2022
R
PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy
Active, not recruiting
  • Carcinoma, Basal Cell
  • Phoenix, Arizona
  • +70 more
2022-03-21
Mar 21, 2022
J
LDE225 in Patients With Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis - 2017
Completed
  • Hepatocellular Carcinoma
  • Cirrhosis
  • La Jolla, California
    UCSD Moores Cancer Center
2019-03-03
Mar 3, 2019
O
SMMART Adaptive Clinical Treatment (ACT) Trial
Not yet recruiting
  • Anatomic Stage IV Breast Cancer AJCC v8
  • +18 more
  • Biopsy
  • +25 more
  • Portland, Oregon
    OHSU Knight Cancer Institute
2022-02-11
Feb 11, 2022
O
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
Recruiting
  • Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  • +58 more
  • Portland, Oregon
    OHSU Knight Cancer Institute
2022-02-16
Feb 16, 2022
E
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
Not yet recruiting
  • Solid Tumors With PTCH1 Loss-of-function Mutations
  • ENV-101 (taladegib)
  • San Diego, California
  • +4 more
2022-01-05
Jan 5, 2022
G
Tailored Sonidegib Schedule After Complete Response in BCC
Recruiting
  • Locally Advanced Basal Cell Carcinoma
  • Brescia, Italy
    Asst Degli Spedali Civili Di Brescia
2021-03-17
Mar 17, 2021
N
A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients With Extensive Stage - 2016
Completed
Has Results
  • Extensive Stage Small Cell Lung Carcinoma
  • Recurrent Small Cell Lung Carcinoma
  • Scottsdale, Arizona
  • +300 more
2020-12-10
Dec 10, 2020
S
Gemcitabine + Nab-paclitaxel With LDE-225 (Hedgehog Inhibitor) as Neoadjuvant Therapy for Pancreatic Adenocarcinoma - 2018
Terminated
Has Results
  • Pancreatic Ductal Adenocarcinoma
  • Baltimore, Maryland
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2020-01-17
Jan 17, 2020
N
GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery
Active, not recruiting
  • Adult Solid Neoplasm
  • +4 more
  • Diagnostic Laboratory Biomarker Analysis
  • +3 more
  • Scottsdale, Arizona
  • +3 more
2022-03-15
Mar 15, 2022
N
Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma - 2015
Completed
Has Results
  • Adult Alveolar Soft Part Sarcoma
  • +34 more
  • Gamma-Secretase Inhibitor RO4929097
  • +3 more
  • New York, New York
    Memorial Sloan-Kettering Cancer Center
2018-07-16
Jul 16, 2018
S
Ribavirin and Hedgehog Inhibitor With or Without Decitabine in AML
Unknown status
  • Acute Myeloid Leukemia
  • Montreal, Quebec, Canada
    Jewish General Hospital
2017-03-06
Mar 6, 2017
S
Hedgehog Inhibitors for Metastatic Adenocarcinoma of the Pancreas - 2018
Completed
Has Results
  • Metastatic Pancreatic Cancer
  • Gemcitabine, nab-Paclitaxel, GDC-0449
  • Scottsdale, Arizona
  • +2 more
2019-04-02
Apr 2, 2019
P
An Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas in Patients With Non-Gorlin High Frequency BCC - 2021
Terminated
  • Recurrent Basal Cell Carcinoma
  • Patidegib Topical Gel, 2%
  • Patidegib Topical Gel, Vehicle
  • Apple Valley, California
  • +13 more
2021-05-25
May 25, 2021
G
A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential - 2010
Completed
  • Healthy
  • GDC-0449 oral capsules (non-labeled)
  • +2 more
  • (no location specified)
2017-06-23
Jun 23, 2017
G
Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma - 2015
Terminated
Has Results
  • Pontine Glioma
  • Phoenix, Arizona
  • +1 more
2020-11-18
Nov 18, 2020
H
Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS) - 2019
Completed
  • Basal Cell Carcinoma in Basal Cell Nevus Syndrome
  • Oceanside, California
  • +4 more
2020-08-03
Aug 3, 2020
A
Phase I/II Study of LDE225 With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer - 2019
Completed
  • Pancreatic Cancer
  • gemcitabine and nab paclitaxel
  • Amsterdam, Netherlands
    Academic Medical Center
2020-01-07
Jan 7, 2020
G
A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists - 2010
Completed
Has Results
  • Solid Cancers
  • (no location specified)
2017-06-08
Jun 8, 2017