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Lentiviral vector

Showing 26 - 50 of 734
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Mucopolysaccharidosis Type IIIA Trial in Manchester (Autologous CD34+ cells transduced with a lentiviral vector containing the

Active, not recruiting
  • Mucopolysaccharidosis Type IIIA
  • Autologous CD34+ cells transduced with a lentiviral vector containing the human SGSH gene
  • Manchester, United Kingdom
    Manchester University NHS Foundation Trust
Jul 2, 2021

Severe Combined Immunodeficiency, X Linked, Gene Therapy Trial in United Kingdom, United States (autologous CD34+ cell

Recruiting
  • Severe Combined Immunodeficiency, X Linked
  • Gene Therapy
  • autologous CD34+ cell transduced with G2SCID vector
  • Los Angeles, California
  • +4 more
Jul 19, 2022

Severe Combined Immunodeficiency Trial in San Francisco (AProArt, CliniMACS® CD34 Reagent System cell sorter device, Busulfan)

Recruiting
  • Severe Combined Immunodeficiency
  • San Francisco, California
    University of California, San Francisco (UCSF) Children's Hospit
Feb 4, 2022

Adenosine Deaminase Deficiency, Severe Combined Immunodeficiencies (SCID) Trial in London (genetic, other, drug)

Completed
Has Results
  • Adenosine Deaminase Deficiency
  • Severe Combined Immunodeficiencies (SCID)
  • Infusion of autologous EFS-ADA LV CD34+ cells
  • +3 more
  • London, United Kingdom
    Great Ormond Street Hospital for Children NHS Foundation Trust
Aug 20, 2021

Lymphoid Leukemia Trial in Palo Alto (Allogeneic donor-derived T-cells transduced with bivalent lentiviral vector

Not yet recruiting
  • Lymphoid Leukemia
  • Allogeneic donor-derived T-cells transduced with bivalent lentiviral vector (CD19/CD22-BBz) chimeric antigen receptor (CAR)
  • Treg CD34+ HSPC (Orca-T)
  • Palo Alto, California
    Stanford Cancer Center
Aug 17, 2022

HIV Trial in Sacramento, San Francisco (drug, biological, other)

Recruiting
  • HIV Infections
  • Sacramento, California
  • +1 more
May 17, 2022

Lysosomal Storage Disease, Metachromatic Leukodystrophy Trial in Milan (OTL-200)

Active, not recruiting
  • Lysosomal Storage Disease
  • Metachromatic Leukodystrophy
  • OTL-200
  • Milan, Italy
    Ospedale San Raffaele - Telethon Institute for Gene Therapy (OSR
Sep 29, 2021

B Cell Leukemias, B Cell Lymphomas Trial in Philadelphia (CART22 cells transduced with a lentiviral vector to express anti-CD22

Recruiting
  • B Cell Leukemias
  • B Cell Lymphomas
  • CART22 cells transduced with a lentiviral vector to express anti-CD22 scFv TCRz:41BB
  • Philadelphia, Pennsylvania
    Children's Hospital of Philadelphia
Jan 19, 2022

Anemia, Sickle Cell Trial in Duarte (Autologous enriched CD34+ cell fraction that contains CD34+ cells transduced with

Terminated
  • Anemia, Sickle Cell
  • Autologous enriched CD34+ cell fraction that contains CD34+ cells transduced with lentiviral vector encoding human γ-globinG16D and short-hairpin RNA734
  • Duarte, California
    City of Hope Medical Center
Jun 14, 2021

Sickle Cell Disease Trial in Boston (Autologous CD34+ HSC cells transduced with the lentiviral vector containing a shRNA

Recruiting
  • Sickle Cell Disease
  • Autologous CD34+ HSC cells transduced with the lentiviral vector containing a shRNA targeting BCL11a
  • Los Angeles, California
  • +8 more
Jan 10, 2023

Leukocyte Adhesion Defect - Type I Trial in Madrid (RP-L201)

Withdrawn
  • Leukocyte Adhesion Defect - Type I
  • RP-L201
  • Madrid, Spain
    Hospital Infantil Universitario Niño Jesús (HIUNJ)
Nov 23, 2021

Severe Combined Immunodeficiency Due to ADA Deficiency Trial in London (Infusion of autologous cryopreserved EFS-ADA LV CD34+

Active, not recruiting
  • Severe Combined Immunodeficiency Due to ADA Deficiency
  • Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells (OTL-101)
  • +2 more
  • London, United Kingdom
    Great Ormond Street Hospital for Children NHS Foundation Trust
Dec 17, 2021

Leukocyte Adhesion Defect - Type I Trial in Los Angeles, Madrid, London (RP-L201)

Active, not recruiting
  • Leukocyte Adhesion Defect - Type I
  • RP-L201
  • Los Angeles, California
  • +2 more
Nov 19, 2021

Sickle Cell Disease Treated With Ex Vivo Gene Therapy

Enrolling by invitation
  • Sickle Cell Disease
  • Safety and efficacy assessments
  • Birmingham, Alabama
  • +11 more
Oct 31, 2022

Wiskott-Aldrich Syndrome Trial in Paris, London (Autologous CD34+ cells transduced with WASP lentiviral vector)

Active, not recruiting
  • Wiskott-Aldrich Syndrome
  • Autologous CD34+ cells transduced with WASP lentiviral vector
  • Paris, France
  • +1 more
May 31, 2021

Pyruvate Kinase Deficiency Trial in Stanford, Madrid (RP-L301)

Recruiting
  • Pyruvate Kinase Deficiency
  • RP-L301
  • Stanford, California
  • +2 more
Sep 22, 2021

X-Linked Chronic Granulomatous Disease Trial in Paris (X vivo gene therapy)

Active, not recruiting
  • X-Linked Chronic Granulomatous Disease
  • X vivo gene therapy
  • Paris, France
    Hôpital Necker Enfants Malades
May 20, 2021

CNS Lymphoma Trial in Duarte (procedure, biological, drug)

Recruiting
  • Central Nervous System Lymphoma
  • Aspiration
  • +10 more
  • Duarte, California
    City of Hope Medical Center
Dec 8, 2022

HLA-A*0201 Positive Cells Present, NY-ESO-1 Positive Tumor Cells Present, Recurrent Myxoid Liposarcoma Trial in Houston

Active, not recruiting
  • HLA-A*0201 Positive Cells Present
  • +3 more
  • Aldesleukin
  • +3 more
  • Houston, Texas
    M D Anderson Cancer Center
Feb 25, 2022

Hematologic Diseases Trial in Kunming (BD211 Drug Product)

Enrolling by invitation
  • Hematologic Diseases
  • BD211 Drug Product
  • Kunming, Yunnan, China
    920th Hospital of Joint Logistics Support Force of People's Libe
Aug 14, 2021

X-Linked Chronic Granulomatous Disease Trial in London (X vivo gene therapy)

Active, not recruiting
  • X-Linked Chronic Granulomatous Disease
  • X vivo gene therapy
  • London, United Kingdom
  • +1 more
May 20, 2021

Wiskott-Aldrich Syndrome Trial in London (Autologous CD34 positive cells transduced with a lentiviral vector containing human

Completed
  • Wiskott-Aldrich Syndrome
  • Autologous CD34 positive cells transduced with a lentiviral vector containing human WAS gene
  • London, United Kingdom
  • +1 more
May 31, 2021

Fanconi Anemia Complementation Group A Trial in Madrid (RP-L102)

Recruiting
  • Fanconi Anemia Complementation Group A
  • RP-L102
  • Madrid, Spain
    Hospital Infantil Universitario Niño Jesús (HIUNJ)
Oct 16, 2020

Fanconi Anemia Complementation Group A Trial in Stanford, Minneapolis (RP-L102)

Recruiting
  • Fanconi Anemia Complementation Group A
  • RP-L102
  • Stanford, California
  • +1 more
Nov 23, 2020

Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non-Hodgkin Lymphoma, MALT Trial in Duarte (biological, procedure,

Active, not recruiting
  • Adult Grade III Lymphomatoid Granulomatosis
  • +23 more
  • autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells
  • +2 more
  • Duarte, California
    City of Hope Medical Center
Jan 4, 2023