Evaluation of 41 Cases of Pediatric Granuloma Annulare

Sponsor

Istanbul Training and Research Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT05472636

Collaborator

(none)

Enrollment

Location

2.7

Actual Duration (Months)

15.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.

MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

Condition or Disease	Intervention/Treatment	Phase
Granuloma Annulare

Detailed Description

Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.

This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Study Design

Study Type:

Observational

Actual Enrollment :

41 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Clinical and Histopathological Evaluation of 41 Cases of Pediatric Granuloma Annulare

Actual Study Start Date :

Mar 11, 2022

Actual Primary Completion Date :

May 11, 2022

Actual Study Completion Date :

Jun 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Patients Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare

Outcome Measures

Primary Outcome Measures

Evaluation of the genders of the pediatric patients with granuloma annulare [day 0]
male, female
Evaluation of the ages of the pediatric patients with granuloma annulare [day 0]
age (year)
Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare [day 0]
the concomitant diseases of the participants
Evaluation of the lesion localization of the pediatric patients with granuloma annulare [day 0]
head and neck, upper extremity, lower extremity, trunk
Evaluation of the lesion duration of the pediatric patients with granuloma annulare [day 0]
the time interval in between appearance of the lesion and diagnosis (month)
Evaluation of the lesion type of the pediatric patients with granuloma annulare [day 0]
papule, pustule, plaque, nodule
Evaluation of the mean size of the lesion [day 0]
diameter (cm)
Evaluation of the clinical involvement [day 0]
localized, generalized
Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare [day 0]
neutrophilic, lymphocytic, lymphohistiocytic, eosinophil, mixed infiltrations
Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare [day 0]
Interstitial, palisadic
Evaluation of epidermal findings [day 0]
regular/irregular, hyperkeratosis, acanthosis
Evaluation of depth of infiltrate [day 0]
superficial, medium, deep

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A to 18 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Being under 18 years old
Having granuloma annulare
Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021
Consenting to participate in the study

Exclusion Criteria:

-Being over 18 years old

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Istanbul Training and Research Hospital	Istanbul		Turkey	34098

Sponsors and Collaborators

Istanbul Training and Research Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Ayse Esra Koku Aksu, Assoc. Prof., Istanbul Training and Research Hospital

ClinicalTrials.gov Identifier:

NCT05472636

Other Study ID Numbers:

First Posted:

Jul 25, 2022

Last Update Posted:

Jul 25, 2022

Last Verified:

Jul 1, 2022

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Ayse Esra Koku Aksu, Assoc. Prof., Istanbul Training and Research Hospital

Granuloma Annulare

Pediatric Dermatology

Pediatric Granuloma Annulare

Additional relevant MeSH terms:

Granuloma

Granuloma Annulare

Study Results

No Results Posted as of Jul 25, 2022