The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension

Sponsor

Baker Heart and Diabetes Institute (Other)

Overall Status

Unknown status

CT.gov ID

NCT01360710

Collaborator

(none)

100

Enrollment

Location

Arms

Study Details

Study Description

Brief Summary

Obesity is a major risk factor for the development of hypertension. Based on population studies, risk estimates indicate that at least two-thirds of the prevalence of hypertension can be directly attributed to obesity. Obesity per se is commonly associated with activation of the sympathetic nervous system with a predominant increase in sympathetic outflow to the kidneys and the peripheral vasculature and there is now conclusive evidence that heightened sympathetic nerve activity is a major contributor to the elevation in blood pressure associated with obesity, particularly in young subjects. In line with these findings, dietary weight loss has repeatedly been demonstrated to result in reduced sympathetic nerve activity and lower blood pressure levels.

Several lines of evidence have well documented the significant role of SNS activation in obesity associated hypertension and target organ damage. Weight loss is the preferred treatment option for obesity and its consequences and reduces both SNS activation and blood pressure. In the real world however, weight loss maintenance is rarely achieved in obese patients highlighting the urgent need for alternative treatment strategies. Given the crucial involvement of SNS activation in various aspects of the obesity related increase in blood pressure, target organ damage and cardiovascular risk, the use of sympatho-inhibitory agents at an early stage is an obvious choice.

The investigators therefore plan to examine the effects of the centrally sympatholytic agent moxonidine on blood pressure and the morning surge in blood pressure, sympathetic activity, regression of early target organ damage (heart, kidney and endothelium), metabolic and inflammatory markers in young obese subjects with hypertension in a randomized, double-blind clinical trial with the angiotensin receptor blocker irbesartan as an active comparator to achieve similar blood pressure reductions in both groups. The investigators hypothesize that moxonidine treatment will result in significant improvements in these outcome parameters and beneficial effects beyond simple blood pressure reduction.

Findings from this study could pave the way for an early and pathophysiology- tailored treatment strategy of obesity related hypertension and its detrimental consequences.

Condition or Disease	Intervention/Treatment	Phase
Abdominal Obesity Hypertension	Drug: Moxonidine Drug: Irbesartan	Phase 4

Study Design

Study Type:

Interventional

Anticipated Enrollment :

100 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Care Provider, Investigator)

Primary Purpose:

Treatment

Official Title:

The Effect of Moxonidine and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension: a Randomised, Double Blind, Active Comparator Clinical Trial

Study Start Date :

Jan 1, 2012

Anticipated Primary Completion Date :

Jan 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Moxonidine	Drug: Moxonidine 0.2mg/day for 2 weeks, 0.4mg/day for 6 months Other Names: Brand name = Physiotens
Active Comparator: Irbesartan	Drug: Irbesartan 75 mg/day for 2 weeks and then 150 mg/day for 24 weeks.

Arm

Intervention/Treatment

Experimental: Moxonidine

Drug: Moxonidine

0.2mg/day for 2 weeks, 0.4mg/day for 6 months

Other Names:

Brand name = Physiotens

Active Comparator: Irbesartan

Drug: Irbesartan

75 mg/day for 2 weeks and then 150 mg/day for 24 weeks.

Outcome Measures

Primary Outcome Measures

Microneurography (nerve recording) [6 months]
Microneurography technique will be performed on participants at baseline and 6 months post treatment to see if moxonidine has any effect in the reduction of sympathetic activiry.

Secondary Outcome Measures

Blood test [6 months]
Blood samples will be taken from antecubital vein for biochemical analyses purposes. The sampling will take place at baseline and at 6 months visit.