Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Study Details
Study Description
Brief Summary
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Healthy controls (HC) will be studied as outpatient and undergo one MRI and one 11C-UCB-J PET scan along with neurocognitive tasks. Individuals with Cocaine Use Disorder (CUD) will complete the study as inpatients on our unit and undergo one MRI and two 11C-UCB-J PET scan along with neurocognitive tasks. Cocaine users will be asked to complete outpatient follow-ups twice a week for up to nine weeks following their inpatient stay.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Cocaine Use Disorder
|
Radiation: 11C-UCB-J
11C-UCB-J PET scan
|
| Healthy Control
|
Radiation: 11C-UCB-J
11C-UCB-J PET scan
|
Outcome Measures
Primary Outcome Measures
- Between-group (CUD vs. HC) comparisons in ACC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of the fP-corrected total volume of distribution (VT/fP) in ACC.
- Between-group (CUD vs. HC) comparisons in vmPFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of the fP-corrected total volume of distribution (VT/fP) in vmPFC.
- Between-group (CUD vs. HC) comparisons in mOFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of the fP-corrected total volume of distribution (VT/fP) in mOFC.
Secondary Outcome Measures
- Within subjects (CUD group) comparisons in ACC. [Baseline versus 3 weeks after.]
Within subjects (CUD group) comparisons (i.e., baseline/pre-abstinence vs. after 3 weeks of inpatient abstinence) of the fP-corrected total volume of distribution (VT/fP) in ACC.
- Within subjects (CUD group) comparisons in vmPFC. [Baseline versus 3 weeks after.]
Within subjects (CUD group) comparisons (i.e., baseline/pre-abstinence vs. after 3 weeks of inpatient abstinence) of the fP-corrected total volume of distribution (VT/fP) in vmPFC.
- Within subjects (CUD group) comparisons in mOFC. [Baseline versus 3 weeks after.]
Within subjects (CUD group) comparisons (i.e., baseline/pre-abstinence vs. after 3 weeks of inpatient abstinence) of the fP-corrected total volume of distribution (VT/fP) in mOFC.
- Between-group (CUD vs. HC) of volume of distribution comparisons in ACC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of volume of distribution (VT) in ACC.
- Between-group (CUD vs. HC) of volume of distribution comparisons in vmPFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of volume of distribution (VT) in vmPFC.
- Between-group (CUD vs. HC) of volume of distribution comparisons in mOFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of volume of distribution (VT) in mOFC.
- Between-group (CUD vs. HC) comparisons of binding potential in ACC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of binding potential (BPND) in ACC.
- Between-group (CUD vs. HC) comparisons of binding potential in vmPFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of binding potential (BPND) in vmPFC.
- Between-group (CUD vs. HC) comparisons of binding potential in mOFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of binding potential (BPND) in mOFC.
- Between-group (CUD vs. HC) comparisons of gray matter volume in ACC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of gray matter volume (GMV) in ACC.
- Between-group (CUD vs. HC) comparisons of gray matter volume in vmPFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of gray matter volume (GMV) in vmPFC.
- Between-group (CUD vs. HC) comparisons of gray matter volume in mOFC. [CUD: After 3 weeks of inpatient abstinence. HC: At baseline as outpatient.]
Between-group comparisons of gray matter volume (GMV) in mOFC.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age 21-60 years
-
Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
-
For females, a negative serum pregnancy test
-
For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
-
For HC: Negative urine toxicology
Exclusion Criteria:
-
DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
-
A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
-
A history of significant and/or uncontrolled medical or neurological illness
-
Current use of psychotropic and/or potentially psychoactive prescription medications
-
Medical contraindications to MRI procedure
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Connecticut Mental Health Center | New Haven | Connecticut | United States | 06519 |
Sponsors and Collaborators
- Yale University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2000029552