Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
Study Details
Study Description
Brief Summary
POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle & sphincter of the LES for the treatment of achalasia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Achalasia is a disease of the muscle of the esophagus (food tube) & means "a failure to relax." The esophagus consists of 3 parts: the first part (uppermost part) is the upper esophageal sphincter (UES). The UES is a specialized ring of muscle which separates the esophagus from the throat, & prevents food in the second part (body) of the esophagus from regurgitating into the throat. The third part of the esophagus (lower esophageal sphincter [LES]) also consists of a specialized ring of muscle which separates the body of the esophagus from the stomach, & prevents food & acid from regurgitating into the body of the esophagus. When achalasia is present, patients experience dysphasia (difficulty swallowing food, & [sometimes] liquids), chest pain & can experience recurrent pneumonia & loss of weight.
Current treatments for achalasia include oral medications (calcium channel blockers) to relax the LES (difficult to swallow pill/capsule), dilation (stretching) of the LES, (temporary relief) & Esophagomyotomy (general surgery to cut the LES).
POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle & sphincter of the LES for the treatment of achalasia.
Study Design
Outcome Measures
Primary Outcome Measures
- This is a tracking system for specific treatment modalities, and data to determine the impact of endoscopic ultrasound for patients with achalasia. Achalasia is a disease of the muscle of the esophagus (food tube) & means "a failure to relax." [5 years]
Data will be collected for research purposes only, to determine the clinical impact of endoscopic ultrasound treatment of achalasia
Secondary Outcome Measures
- Improved achalasia management. [5 years]
The purpose of tracking this data will also help the physicians to better understand the patient's condition and disease process, which may lead to improved standard of care and improved patient management.
Eligibility Criteria
Criteria
Inclusion Criteria:
18 years of age Referral for the treatment of Achalasia
Exclusion Criteria:
Less than 18 years of age; Absence of Achalasia
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Indiana University Hospital | Indianapolis | Indiana | United States | 46202-5121 |
Sponsors and Collaborators
- Indiana University
Investigators
- Principal Investigator: John M DeWitt, M.D., Indiana University School of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1410540149