Assessment of Serum Asprosin Level in Male Patients With Acne Vulgaris

• Sponsor: Sohag University (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05471388
• Collaborator: (none)
• Enrollment: 72
• Location: 1
• Arms: 2
• Anticipated Duration (Months): 6
• Patients Per Site Per Month: 11.9

Study Details

Study Description

Brief Summary

Subject of interest is to evaluate serum level of asprosin in male patients with acne vulgaris, demonstrate the relation between acne vulgaris severity and level of asprosin in these patients & the relation between metabolic syndrome in acne vulgaris and level of asprosin.

Condition or Disease	Intervention/Treatment	Phase
Acne Vulgaris	Diagnostic Test: serum asprosin	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 72 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Other
• Official Title: Assessment of Serum Asprosin Level in Male Patients With Acne Vulgaris
• Anticipated Study Start Date: Jul 18, 2022
• Anticipated Primary Completion Date: Jan 18, 2023
• Anticipated Study Completion Date: Jan 18, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: case	Diagnostic Test: serum asprosin; assessment of serum asprosin by a commercially available double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit.
Active Comparator: control	Diagnostic Test: serum asprosin; assessment of serum asprosin by a commercially available double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit.

Outcome Measures

Primary Outcome Measures

1. Assess serum asprosin level in male patients with acne vulgaris. [6 months]

   Assess serum asprosin level in male patients with acne vulgaris.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Acne vulgaris male patients (>18 years) will be included.

Exclusion Criteria:

• Age <18 years.

• Females.

• Patients with other inflammatory skin disorders.

• Patients with associated systemic diseases.

• Current or previous treatment with isotretinoin in the last 3 month ,anti-inflammatory drugs, systemic antibiotics, androgen or anti androgen therapy, and steroid therapy).

• Patients known on treatment of diabetes, hypertension and dyslipidemia.

• Athletes.

• Patient refusal.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Sohag University Hospital	Sohag		Egypt

Sponsors and Collaborators

• Sohag University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

• Hong T, Li JY, Wang YD, Qi XY, Liao ZZ, Bhadel P, Ran L, Yang J, Yan B, Liu JH, Xiao XH. High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome. Int J Endocrinol. 2021 Mar 2;2021:6622129. doi: 10.1155/2021/6622129. eCollection 2021.
• Kovács D, Fazekas F, Oláh A, Törőcsik D. Adipokines in the Skin and in Dermatological Diseases. Int J Mol Sci. 2020 Nov 28;21(23). pii: E9048. doi: 10.3390/ijms21239048. Review.
• Nagpal M, De D, Handa S, Pal A, Sachdeva N. Insulin Resistance and Metabolic Syndrome in Young Men With Acne. JAMA Dermatol. 2016 Apr;152(4):399-404. doi: 10.1001/jamadermatol.2015.4499.
• Rocha MA, Bagatin E. Adult-onset acne: prevalence, impact, and management challenges. Clin Cosmet Investig Dermatol. 2018 Feb 1;11:59-69. doi: 10.2147/CCID.S137794. eCollection 2018. Review.

• Responsible Party: Esraa Abdel-Azeem Hamoda, resident doctor at Dematology, Venereology and Andrology department at Sohag University Hospital, Sohag University
• ClinicalTrials.gov Identifier: NCT05471388
• Other Study ID Numbers: Soh-Med-22-07-06
• First Posted: Jul 22, 2022
• Last Update Posted: Jul 22, 2022
• Last Verified: Jul 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Esraa Abdel-Azeem Hamoda, resident doctor at Dematology, Venereology and Andrology department at Sohag University Hospital, Sohag University: Asprosin
• Additional relevant MeSH terms: Marfan Syndrome; Acne Vulgaris

Study Results

No Results Posted as of Jul 22, 2022