A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03698019
• Collaborator: (none)
• Enrollment: 336
• Locations: 823
• Arms: 2
• Anticipated Duration (Months): 44.8
• Patients Per Site: 0.4
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase II trial studies how pembrolizumab works before and after surgery in treating patients with stage III-IV high-risk melanoma. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab before and after surgery may work better compared to after surgery alone in treating melanoma.

Condition or Disease	Intervention/Treatment	Phase
Acral Lentiginous Melanoma; Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Mucosal Melanoma; Pathologic Stage IIIB Cutaneous Melanoma AJCC v8; Pathologic Stage IIIC Cutaneous Melanoma AJCC v8; Pathologic Stage IIID Cutaneous Melanoma AJCC v8; Pathologic Stage IV Cutaneous Melanoma AJCC v8	Biological: Pembrolizumab; Procedure: Therapeutic Conventional Surgery	Phase 2

Detailed Description

PRIMARY OBJECTIVE:

1. To compare event-free survival (EFS) in participants with high-risk resectable melanoma randomized to neoadjuvant pembrolizumab (MK-3475) with participants randomized to adjuvant pembrolizumab (MK-3475).

SECONDARY OBJECTIVES:

1. To assess the frequency and severity of toxicities on each of the arms. II. To compare between arms overall survival (OS), disease control at 24 weeks, locoregional control in the surgical site(s), and total number of pembrolizumab (MK-3475) doses received.

2. On the neoadjuvant arm, to estimate the pathologic response rate, the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 response rate (confirmed and unconfirmed complete response [CR] and partial response [PR]), and the immune-related (i)RECIST response rate (confirmed and unconfirmed CR and PR), before surgical resection; to compare definitions of pathologic partial response; and to evaluate the association between pathologic response and EFS and OS.

3. To describe the proportion of participants on each arm who received the surgery planned at randomization.

ADDITIONAL OBJECTIVE:

1. To bank tumor tissue and whole blood in anticipation of future correlative studies in this participant population.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Within 17 days (preferably within 14 days) days after surgical resection, patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment repeats every 3 weeks for 18 cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive pembrolizumab IV over 30 minutes on day 1 every 3 weeks for 3 cycles, then undergo surgical resection within 3 weeks. Within 84 days, patients receive pembrolizumab IV over 30 minutes every 3 weeks for 15 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 3 and 12 weeks, then every 3 months for 2 years, every 6 months for 3 years, then every 12 months for up to a total of 10 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 336 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Phase II Randomized Study of Adjuvant Versus NeoAdjuvant Pembrolizumab (MK-3475) for Clinically Detectable Stage III-IV High-Risk Melanoma
• Actual Study Start Date: Dec 6, 2018
• Anticipated Primary Completion Date: Sep 1, 2022
• Anticipated Study Completion Date: Sep 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm I (adjuvant pembrolizumab) Within 17 days (preferably within 14 days) days after IV over 30 minutes on day 1. Treatment repeats every 3 weeks for 18 cycles in the absence of disease progression or unacceptable toxicity.	Biological: Pembrolizumab; Given IV; Other Names: Keytruda Lambrolizumab MK-3475 SCH 900475 ; Procedure: Therapeutic Conventional Surgery; Undergo surgery
Active Comparator: Arm II (adjuvant and neoadjuvant pembrolizumab) Patients receive pembrolizumab IV over 30 minutes on day 1 every 3 weeks for 3 cycles, then undergo surgery within 3 weeks. Within 84 days, patients receive pembrolizumab IV over 30 minutes every 3 weeks for 15 cycles in the absence of disease progression or unacceptable toxicity.	Biological: Pembrolizumab; Given IV; Other Names: Keytruda Lambrolizumab MK-3475 SCH 900475 ; Procedure: Therapeutic Conventional Surgery; Undergo surgery

Outcome Measures

Primary Outcome Measures

1. Event-free survival (EFS) in patients with high-risk resectable melanoma randomized to neoadjuvant pembrolizumab with patients randomized to adjuvant pembrolizumab [Date of randomization to date of first progression or death, assessed up to 10 years]

   We will use exponential-mixture cure models to describe EFS patterns in the arms.

Secondary Outcome Measures

1. Overall survival [From date of randomization to date of death due to any cause, assessed up to 10 years]

   Will be estimated using the Kaplan-Meier method and compared between arms using log-rank tests and Cox regression models.

2. Disease control [At 24 weeks]

   Will be estimated using the Kaplan-Meier method and compared between arms using log-rank tests and Cox regression models.

3. Local/regional control in the surgical site(s) [Up to 10 years]

   Will be estimated using the Kaplan-Meier method and compared between arms using log-rank tests and Cox regression models.

4. Total number of pembrolizumab doses [Up to 10 years]

   Will use Fisher's exact test to compare the number of pembrolizumab doses received by patients on each treatment arm.

5. Pathologic response rate [Up to 10 years]

   Will be tabulated for the neoadjuvant arm and exact 95% confidence intervals will be constructed.

6. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 response rate [Up to 10 years]

   Will be tabulated for the neoadjuvant arm and exact 95% confidence intervals will be constructed.

7. Immune-related RECIST response rate [Up to 10 years]

   Will be tabulated for the neoadjuvant arm and exact 95% confidence intervals will be constructed.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must have clinically detectable stage III (clinically detectable N1b, N1c, N2b, N2c, N3b and N3c) or stage IV resectable melanoma. Patients with melanoma of mucosal or acral origin are eligible. Patients with melanoma of uveal origin are not eligible. Patients with a history of brain metastases are not eligible. Clinically detectable is defined as disease that is apparent and measurable via physical examination or radiographic imaging.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients are eligible for this trial either at initial presentation of their melanoma or at the time of the first detected nodal, satellite/in-transit, distant metastases, or recurrent disease in prior lymphadenectomy basin or distant site. Nodal, satellite/in-transit metastasis, distant metastases or disease in a prior complete lymphadenectomy basin must have been confirmed histologically by hematoxylin (H) & eosin (E) stained slides.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients with multiple regional nodal basin involvement are eligible. Gross or microscopic extracapsular nodal extension is permitted.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must have histologically proven stage IIIB or higher. This would entail pathologic confirmation beyond the primary or initial diagnosis of melanoma involving fine needle aspiration cytology or biopsy confirmation of any N-category or M-category resectable site.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients may have received prior radiation therapy, including after prior surgical resection. All adverse events associated with prior surgery and radiation therapy must have resolved to =< grade 1 prior to randomization.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must be >= 18 years of age

• STEP 1 REGISTRATION (RANDOMIZATION): All patients must have disease status documented by a complete physical examination and imaging studies within 42 days prior to randomization. Imaging studies must include a CT of the chest, abdomen and pelvis with intravenous contrast (unless contraindicated). For patients with melanoma arising from the head and neck, dedicated neck imaging (CT with intravenous contrast is required. If the patient has unknown primary with disease in the axilla, neck imaging is required CT imaging must be done with intravenous contrast if there are no contraindications for it. Extremity melanomas must be imaged using CT with intravenous contrast or MRI with and without gadolinium

• Note: PET-CT scans are NOT acceptable to establish eligibility. Non-iodinated CT scans that are part of common PET-CT imaging protocols do not provide contrast for difficult to ascertain areas such as the neck and liver, and do not provide enough CT detail to perform appropriate RECIST 1.1 measurements. As such, a PET-CT with non-contrast CT or non-diagnostic quality CT images is considered insufficient for the detection of melanoma.

• STEP 1 REGISTRATION (RANDOMIZATION): All patients must have a CT or magnetic resonance imaging (MRI) of the brain within 42 days prior to randomization. The brain CT or MRI should be performed with intravenous contrast (unless contraindicated).

• STEP 1 REGISTRATION (RANDOMIZATION): Absolute neutrophil count (ANC) >= 1,500/microliter (mcL) (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Platelets >= 100,000/mcL (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Hemoglobin >= 10 g/dL (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except patients with Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) and serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 2 x IULN (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Alkaline phosphatase =< 2 x IULN (within 42 days prior to randomization).

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must have lactate dehydrogenase (LDH) performed within 42 days prior to randomization.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must have adequate renal function as evidenced by calculated creatinine clearance > 30 mL/min. The creatinine level (mg/dL) used in the calculation must be obtained within 42 days prior to randomization.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must have Zubrod performance status =<

• STEP 1 REGISTRATION (RANDOMIZATION): Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following criteria within 30 days prior to randomization: stable and adequate CD4 counts (>= 350 mm^3), and serum HIV viral load of < 25,000 IU/ml. Patients may be on or off anti-viral therapy so long as they meet the CD4 count criteria.

• STEP 1 REGISTRATION (RANDOMIZATION): Prior malignancy is allowed providing it does not require concurrent therapy.

• STEP 1 REGISTRATION (RANDOMIZATION): Women of childbearing potential must have a negative urine or serum pregnancy test within 28 days prior to randomization. Women/men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study through 120 days after the last dose of study medication. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy, or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures. Patients must not be pregnant or nursing due to unknown teratogenic side effects.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must be deemed medically fit to undergo surgery by the treating medical/surgical team.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must be willing to submit the following surgical specimens: either all tissue blocks from the surgical specimen or two slides per block ([1] hematoxylin and eosin [H&E] slide and [1] unstained slide OR [2] unstained slides if H&E stained slides cannot be provided).

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must be offered the opportunity to participate in specimen banking.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must be informed of the investigational nature of this study and must sign and give written informed consent for this protocol in accordance with institutional and federal guidelines.

• STEP 1 REGISTRATION (RANDOMIZATION): As a part of the Oncology Patient Enrollment Network (OPEN) randomization process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

• STEP 2 REGISTRATION (SURGERY): Patients randomized to arm 2 (neoadjuvant arm) must be willing to submit tissue to determine pathologic response regardless of number of pre-operative doses of pembrolizumab (MK-3475) received. Determination of pathologic response cannot be done on less than the full surgical specimen.

• STEP 2 REGISTRATION (SURGERY): Patients must have disease assessments by CT chest/abdomen/pelvis with IV contrast, and neck CT with IV contrast if primary head and neck melanoma, performed within 42 days (and no more than 49 days) before the planned date of surgery. MRI combined with non-contrast CT is an acceptable alternative for patients with CT contrast allergy, but imaging must encompass total body.

• STEP 2 REGISTRATION (SURGERY): Patients must register to step 2 within 17 days prior to planned date of surgery.

• STEP 3 REGISTRATION (ADJUVANT THERAPY): Patients must have undergone surgery prior to Step 3 registration. The Step 2 surgery must have completely resected their melanoma.

• Patients with gross positive residual disease following surgery do not qualify as having disease-free status, and, therefore, such patients are not eligible to register for adjuvant therapy.

• Patients with microscopic residual disease (i.e., positive margins) can be treated with re-excision or radiation, per site discretion, to render the patient disease-free prior to registration of adjuvant therapy.

• Disease-free status must be documented by a complete physical examination and radiographic imaging studies within 42 days prior to Step 3 registration. Imaging studies must include a CT of the chest, abdomen, and pelvis (unless contraindicated). Extremity melanomas must be imaged using CT with intravenous contrast or MRI with and without gadolinium. CT imaging must be done with intravenous contrast if there are no contraindications for it.

• For patients with melanoma arising from the head and neck, dedicated neck imaging (CT with IV contrast, unless contraindicated) is required.

• If the patient has had unknown primary with disease in the axilla, neck imaging is required to assure the region is clear of cancer.

• Any other clinically indicated imaging studies if performed (e.g., bone scan) must show no evidence of disease.

• STEP 3 REGISTRATION (ADJUVANT THERAPY): Patients must be registered to step 3 no more than 84 days after date of surgery.

• STEP 3 REGISTRATION (ADJUVANT THERAPY): Patients with R0 or R1 resections must have disease-free status documented by a complete physical examination and imaging studies within 42 days prior to step 3 registration. These patients must have disease assessments by CT chest/abdomen/pelvis with IV contrast, and neck CT with IV contrast if primary head and neck melanoma. MRI combined with non-contrast CT is an acceptable alternative for patients with CT contrast allergy, but imaging must encompass total body.

• STEP 3 REGISTRATION (ADJUVANT THERAPY): Patients with R2 resections are not eligible for step 3 and must be removed from study treatment

Exclusion Criteria:

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have received previous neoadjuvant treatment for their melanoma. Patients may have received prior non-immunotherapy adjuvant therapy. Patients must not have had prior immunotherapy including, but not limited to ipilimumab, interferon alfa-2b, high dose interleukin (IL)-2, pegylated-interferon (PEG-IFN), anti-PD-1, anti-PD-L1 intra-tumoral, or vaccine therapies. Patients must not be planning to receive any of the prohibited therapies during treatment phases on the study.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not be planning to receive concomitant other biologic therapy, hormonal therapy, other chemotherapy, surgery, while on protocol therapy.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have an active infection requiring systemic therapy.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have received live vaccines within 42 days prior to randomization. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed.

• NOTE: The COVID-19 vaccines (currently available and those in the pipeline for FDA emergency use authorization or FDA approval) do not contain live virus, and therefore, COVID-19 vaccination does not affect or preclude eligibility for the S1801 trial. For patients who have undergone lymphadenectomy, vaccines should be delivered to a limb with an intact lymph node basin (Sentinel lymph node biopsy in a limb is acceptable). The vaccine should not be administered in a limb that has undergone lymphadenectomy.

• STEP 1 REGISTRATION (RANDOMIZATION): Patients must not have known active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection prior to randomization. Note: No testing for hepatitis B and hepatitis C is required unless mandated by local health authority.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	United States	36688
3	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
4	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
5	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
6	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
7	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
8	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
9	Katmai Oncology Group	Anchorage	Alaska	United States	99508
10	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
11	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
12	Banner MD Anderson Cancer Center	Gilbert	Arizona	United States	85234
13	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
14	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
15	Banner Boswell Medical Center	Sun City	Arizona	United States	85351
16	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
17	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
18	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
19	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
20	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
21	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
22	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
23	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
24	PCR Oncology	Arroyo Grande	California	United States	93420
25	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
26	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
27	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
28	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
29	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
30	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
31	Eden Hospital Medical Center	Castro Valley	California	United States	94546
32	Sutter Davis Hospital	Davis	California	United States	95616
33	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
34	Epic Care-Dublin	Dublin	California	United States	94568
35	Kaiser Permanente Dublin	Dublin	California	United States	94568
36	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
37	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
38	Kaiser Permanente-Fremont	Fremont	California	United States	94538
39	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
40	Fresno Cancer Center	Fresno	California	United States	93720
41	Kaiser Permanente-Fresno	Fresno	California	United States	93720
42	Keck Medicine of USC Huntington Beach	Huntington Beach	California	United States	92648
43	Loma Linda University Medical Center	Loma Linda	California	United States	92354
44	Veterans Affairs Loma Linda Healthcare System	Loma Linda	California	United States	92357
45	Los Angeles County-USC Medical Center	Los Angeles	California	United States	90033
46	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
47	UCLA / Jonsson Comprehensive Cancer Center	Los Angeles	California	United States	90095
48	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
49	Memorial Medical Center	Modesto	California	United States	95355
50	Kaiser Permanente-Modesto	Modesto	California	United States	95356
51	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
52	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
53	Providence Queen of The Valley	Napa	California	United States	94558
54	USC Norris Oncology/Hematology-Newport Beach	Newport Beach	California	United States	92663
55	Sutter Cancer Research Consortium	Novato	California	United States	94945
56	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
57	Bay Area Tumor Institute	Oakland	California	United States	94609
58	Kaiser Permanente Oakland-Broadway	Oakland	California	United States	94611
59	Kaiser Permanente-Oakland	Oakland	California	United States	94611
60	Saint Joseph Hospital - Orange	Orange	California	United States	92868
61	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
62	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
63	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
64	Keck Medical Center of USC Pasadena	Pasadena	California	United States	91105
65	Kaiser Permanente-Rancho Cordova Cancer Center	Rancho Cordova	California	United States	95670
66	Eisenhower Medical Center	Rancho Mirage	California	United States	92270
67	Kaiser Permanente- Marshall Medical Offices	Redwood City	California	United States	94063
68	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
69	Kaiser Permanente-Richmond	Richmond	California	United States	94801
70	Rohnert Park Cancer Center	Rohnert Park	California	United States	94928
71	Kaiser Permanente-Roseville	Roseville	California	United States	95661
72	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
73	Sutter Roseville Medical Center	Roseville	California	United States	95661
74	The Permanente Medical Group-Roseville Radiation Oncology	Roseville	California	United States	95678
75	Kaiser Permanente Downtown Commons	Sacramento	California	United States	95814
76	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
77	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
78	South Sacramento Cancer Center	Sacramento	California	United States	95823
79	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
80	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
81	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
82	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
83	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
84	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
85	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
86	Kaiser San Rafael-Gallinas	San Rafael	California	United States	94903
87	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
88	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
89	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
90	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
91	Providence Medical Foundation - Santa Rosa	Santa Rosa	California	United States	95403
92	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
93	Providence Santa Rosa Memorial Hospital	Santa Rosa	California	United States	95405
94	Kaiser Permanente Cancer Treatment Center	South San Francisco	California	United States	94080
95	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
96	Kaiser Permanente-Stockton	Stockton	California	United States	95210
97	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
98	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
99	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
100	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
101	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
102	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
103	Epic Care Cyberknife Center	Walnut Creek	California	United States	94597
104	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
105	The Medical Center of Aurora	Aurora	Colorado	United States	80012
106	Boulder Community Hospital	Boulder	Colorado	United States	80301
107	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
108	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
109	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
110	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
111	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
112	Saint Francis Cancer Center	Colorado Springs	Colorado	United States	80923
113	Cancer Center of Colorado at Sloan's Lake	Denver	Colorado	United States	80204
114	Denver Health Medical Center	Denver	Colorado	United States	80204
115	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
116	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
117	The Women's Imaging Center	Denver	Colorado	United States	80209
118	Porter Adventist Hospital	Denver	Colorado	United States	80210
119	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
120	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
121	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
122	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
123	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
124	Rose Medical Center	Denver	Colorado	United States	80220
125	Western Surgical Care	Denver	Colorado	United States	80220
126	Mercy Medical Center	Durango	Colorado	United States	81301
127	Southwest Oncology PC	Durango	Colorado	United States	81301
128	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
129	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
130	Swedish Medical Center	Englewood	Colorado	United States	80113
131	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
132	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
133	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
134	SCL Health Cancer Centers of Colorado - Lutheran Medical Center	Golden	Colorado	United States	80401
135	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
136	North Colorado Medical Center	Greeley	Colorado	United States	80631
137	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
138	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
139	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
140	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
141	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
142	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
143	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
144	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
145	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
146	Longmont United Hospital	Longmont	Colorado	United States	80501
147	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
148	McKee Medical Center	Loveland	Colorado	United States	80539
149	Parker Adventist Hospital	Parker	Colorado	United States	80138
150	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
151	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
152	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
153	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
154	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
155	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
156	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
157	Mount Sinai Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
158	UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	United States	33146
159	UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	United States	33442
160	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
161	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
162	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
163	UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	United States	33176
164	Orlando Health Cancer Institute	Orlando	Florida	United States	32806
165	UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	United States	33324
166	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
167	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
168	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
169	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
170	Summit Cancer Care-Candler	Savannah	Georgia	United States	31405
171	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
172	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
173	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
174	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
175	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
176	Island Urology	Honolulu	Hawaii	United States	96813
177	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
178	Queen's Medical Center	Honolulu	Hawaii	United States	96813
179	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
180	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
181	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
182	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
183	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
184	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
185	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
186	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
187	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
188	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
189	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
190	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
191	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
192	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
193	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
194	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
195	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
196	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
197	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
198	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
199	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
200	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
201	Saint Anthony's Health	Alton	Illinois	United States	62002
202	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
203	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
204	Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	United States	60527
205	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
206	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
207	SIH Cancer Institute	Carterville	Illinois	United States	62918
208	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
209	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
210	Northwestern University	Chicago	Illinois	United States	60611
211	Rush University Medical Center	Chicago	Illinois	United States	60612
212	Carle on Vermilion	Danville	Illinois	United States	61832
213	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
214	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
215	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
216	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
217	Crossroads Cancer Center	Effingham	Illinois	United States	62401
218	Elmhurst Memorial Hospital	Elmhurst	Illinois	United States	60126
219	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
220	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
221	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
222	Loyola Medicine Homer Glen	Homer Glen	Illinois	United States	60491
223	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
224	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
225	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
226	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
227	Loyola University Medical Center	Maywood	Illinois	United States	60153
228	Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	United States	60160
229	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
230	Edward Hospital/Cancer Center	Naperville	Illinois	United States	60540
231	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
232	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
233	Advocate Lutheran General Hospital	Park Ridge	Illinois	United States	60068
234	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
235	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
236	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
237	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
238	Valley Radiation Oncology	Peru	Illinois	United States	61354
239	Edward Hospital/Cancer Center?Plainfield	Plainfield	Illinois	United States	60585
240	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
241	Genesis Cancer Center - Silvis	Silvis	Illinois	United States	61282
242	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
243	Springfield Clinic	Springfield	Illinois	United States	62702
244	Memorial Medical Center	Springfield	Illinois	United States	62781
245	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
246	Carle Cancer Center	Urbana	Illinois	United States	61801
247	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
248	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
249	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
250	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
251	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
252	Franciscan Saint Elizabeth Health - Lafayette East	Lafayette	Indiana	United States	47905
253	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
254	Franciscan Health Mooresville	Mooresville	Indiana	United States	46158
255	Reid Health	Richmond	Indiana	United States	47374
256	Union Hospital	Terre Haute	Indiana	United States	47804
257	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
258	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
259	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
260	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
261	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
262	Greater Regional Medical Center	Creston	Iowa	United States	50801
263	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
264	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
265	Iowa Cancer Specialists	Davenport	Iowa	United States	52807
266	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
267	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
268	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
269	Coffeyville Regional Medical Center	Coffeyville	Kansas	United States	67337
270	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
271	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
272	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
273	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
274	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
275	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
276	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
277	Olathe Health Cancer Center	Olathe	Kansas	United States	66061
278	Menorah Medical Center	Overland Park	Kansas	United States	66209
279	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
280	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
281	Salina Regional Health Center	Salina	Kansas	United States	67401
282	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
283	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
284	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
285	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
286	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
287	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
288	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
289	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
290	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
291	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
292	Saint Joseph London	London	Kentucky	United States	40741
293	Jewish Hospital	Louisville	Kentucky	United States	40202
294	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
295	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
296	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
297	LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	United States	70805
298	Our Lady of The Lake	Baton Rouge	Louisiana	United States	70808
299	Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	United States	70809
300	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
301	Our Lady of the Lake Physicians Group - Medical Oncology	Baton Rouge	Louisiana	United States	70809
302	Ochsner High Grove	Baton Rouge	Louisiana	United States	70836
303	Northshore Oncology Associates-Covington	Covington	Louisiana	United States	70433
304	Ochsner Hematology Oncology North Shore - Covington (West Region)	Covington	Louisiana	United States	70433
305	Oncology Center of The South Incorporated	Houma	Louisiana	United States	70360
306	Terrebonne General Medical Center	Houma	Louisiana	United States	70360
307	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
308	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
309	Eastern Maine Medical Center	Bangor	Maine	United States	04401
310	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
311	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
312	Boston Medical Center	Boston	Massachusetts	United States	02118
313	Mercy Medical Center	Springfield	Massachusetts	United States	01104
314	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
315	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
316	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
317	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
318	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
319	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
320	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
321	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
322	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
323	Caro Cancer Center	Caro	Michigan	United States	48723
324	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
325	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
326	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
327	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
328	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
329	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
330	Henry Ford Hospital	Detroit	Michigan	United States	48202
331	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
332	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
333	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
334	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
335	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
336	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
337	Hurley Medical Center	Flint	Michigan	United States	48503
338	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
339	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
340	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
341	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
342	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
343	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
344	Allegiance Health	Jackson	Michigan	United States	49201
345	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
346	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
347	Ascension Borgess Cancer Center	Kalamazoo	Michigan	United States	49009
348	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
349	Sparrow Hospital	Lansing	Michigan	United States	48912
350	Hope Cancer Clinic	Livonia	Michigan	United States	48154
351	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
352	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
353	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
354	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
355	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
356	Lakeland Hospital Niles	Niles	Michigan	United States	49120
357	Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	United States	49444
358	Ascension Providence Hospitals - Novi	Novi	Michigan	United States	48374
359	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
360	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
361	Hope Cancer Center	Pontiac	Michigan	United States	48341
362	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
363	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
364	Huron Medical Center PC	Port Huron	Michigan	United States	48060
365	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
366	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
367	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
368	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
369	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
370	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
371	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
372	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
373	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
374	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
375	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
376	Munson Medical Center	Traverse City	Michigan	United States	49684
377	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
378	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
379	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
380	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
381	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
382	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
383	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
384	Henry Ford Wyandotte Hospital	Wyandotte	Michigan	United States	48192
385	Metro Health Hospital	Wyoming	Michigan	United States	49519
386	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
387	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
388	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
389	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
390	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
391	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
392	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
393	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
394	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
395	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
396	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
397	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
398	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
399	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
400	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
401	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
402	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
403	Unity Hospital	Fridley	Minnesota	United States	55432
404	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
405	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
406	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
407	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
408	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
409	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
410	Health Partners Inc	Minneapolis	Minnesota	United States	55454
411	Monticello Cancer Center	Monticello	Minnesota	United States	55362
412	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
413	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
414	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
415	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
416	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
417	Regions Hospital	Saint Paul	Minnesota	United States	55101
418	United Hospital	Saint Paul	Minnesota	United States	55102
419	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
420	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
421	Lakeview Hospital	Stillwater	Minnesota	United States	55082
422	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
423	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
424	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
425	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
426	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
427	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
428	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
429	Gulfport Memorial Hospital	Gulfport	Mississippi	United States	39502
430	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
431	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
432	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
433	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
434	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
435	Cox Cancer Center Branson	Branson	Missouri	United States	65616
436	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
437	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
438	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
439	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
440	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
441	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
442	Freeman Health System	Joplin	Missouri	United States	64804
443	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
444	Truman Medical Centers	Kansas City	Missouri	United States	64108
445	Research Medical Center	Kansas City	Missouri	United States	64132
446	University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	United States	64064
447	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
448	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
449	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
450	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
451	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
452	Mercy Hospital South	Saint Louis	Missouri	United States	63128
453	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
454	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
455	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
456	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
457	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
458	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
459	CoxHealth South Hospital	Springfield	Missouri	United States	65807
460	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
461	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
462	Mercy Hospital Washington	Washington	Missouri	United States	63090
463	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
464	Billings Clinic Cancer Center	Billings	Montana	United States	59101
465	Saint Vincent Healthcare	Billings	Montana	United States	59101
466	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
467	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
468	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
469	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
470	Great Falls Clinic	Great Falls	Montana	United States	59405
471	Saint Peter's Community Hospital	Helena	Montana	United States	59601
472	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
473	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
474	Community Medical Hospital	Missoula	Montana	United States	59804
475	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
476	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
477	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
478	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
479	Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	United States	68114
480	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
481	Oncology Associates PC	Omaha	Nebraska	United States	68114
482	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
483	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
484	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
485	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
486	Creighton University Medical Center	Omaha	Nebraska	United States	68131
487	Midlands Community Hospital	Papillion	Nebraska	United States	68046
488	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
489	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
490	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
491	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
492	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
493	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
494	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
495	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
496	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
497	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
498	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
499	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
500	Desert West Surgery	Las Vegas	Nevada	United States	89102
501	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
502	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
503	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
504	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
505	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
506	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
507	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
508	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
509	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
510	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
511	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
512	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
513	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
514	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
515	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
516	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
517	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
518	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
519	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
520	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
521	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
522	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
523	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
524	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
525	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
526	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
527	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
528	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
529	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
530	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
531	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
532	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
533	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
534	University Cancer Center	Las Vegas	Nevada	United States	89169
535	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
536	Renown Regional Medical Center	Reno	Nevada	United States	89502
537	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
538	Radiation Oncology Associates	Reno	Nevada	United States	89509
539	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
540	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
541	Morristown Medical Center	Morristown	New Jersey	United States	07960
542	Overlook Hospital	Summit	New Jersey	United States	07902
543	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
544	New Mexico Oncology Hematology Consultants	Albuquerque	New Mexico	United States	87109
545	Northwell Health Imbert Cancer Center	Bay Shore	New York	United States	11706
546	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
547	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
548	Glens Falls Hospital	Glens Falls	New York	United States	12801
549	Northwell Health/Center for Advanced Medicine	Lake Success	New York	United States	11042
550	Garnet Health Medical Center	Middletown	New York	United States	10940
551	University of Rochester	Rochester	New York	United States	14642
552	Phelps Memorial Hospital Center	Sleepy Hollow	New York	United States	10591
553	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
554	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
555	Wake Forest University at Clemmons	Clemmons	North Carolina	United States	27012
556	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
557	East Carolina University	Greenville	North Carolina	United States	27834
558	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
559	Wake Forest Baptist Health - Hematology Oncology - Statesville	Statesville	North Carolina	United States	28677
560	Wake Forest Baptist Health - Wilkes Medical Center	Wilkesboro	North Carolina	United States	28659
561	Wake Forest University Health Sciences	Winston-Salem	North Carolina	United States	27157
562	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
563	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
564	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
565	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
566	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
567	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
568	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
569	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
570	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
571	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
572	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
573	Cleveland Clinic Mercy Hospital	Canton	Ohio	United States	44708
574	Mercy Hematology and Oncology Associates Inc	Canton	Ohio	United States	44708
575	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
576	Miami Valley Hospital South	Centerville	Ohio	United States	45459
577	Geauga Hospital	Chardon	Ohio	United States	44024
578	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
579	University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	United States	45219
580	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
581	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
582	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
583	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
584	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
585	Case Western Reserve University	Cleveland	Ohio	United States	44106
586	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
587	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
588	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
589	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
590	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
591	Grant Medical Center	Columbus	Ohio	United States	43215
592	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
593	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
594	Doctors Hospital	Columbus	Ohio	United States	43228
595	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
596	Miami Valley Hospital	Dayton	Ohio	United States	45409
597	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
598	Miami Valley Hospital North	Dayton	Ohio	United States	45415
599	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
600	Grady Memorial Hospital	Delaware	Ohio	United States	43015
601	Columbus Oncology and Hematology Associates	Dublin	Ohio	United States	43016
602	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
603	Armes Family Cancer Center	Findlay	Ohio	United States	45840
604	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
605	Orion Cancer Care	Findlay	Ohio	United States	45840
606	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
607	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
608	Central Ohio Breast and Endocrine Surgery	Gahanna	Ohio	United States	43230
609	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
610	Wayne Hospital	Greenville	Ohio	United States	45331
611	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
612	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
613	First Dayton Cancer Care	Kettering	Ohio	United States	45420
614	Kettering Medical Center	Kettering	Ohio	United States	45429
615	Fairfield Medical Center	Lancaster	Ohio	United States	43130
616	Saint Rita's Medical Center	Lima	Ohio	United States	45801
617	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
618	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
619	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
620	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
621	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
622	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
623	Licking Memorial Hospital	Newark	Ohio	United States	43055
624	Newark Radiation Oncology	Newark	Ohio	United States	43055
625	University Hospitals Parma Medical Center	Parma	Ohio	United States	44129
626	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
627	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
628	University Hospitals Portage Medical Center	Ravenna	Ohio	United States	44266
629	UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
630	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
631	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
632	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
633	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
634	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
635	Upper Valley Medical Center	Troy	Ohio	United States	45373
636	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
637	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
638	University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	United States	45069
639	Saint Ann's Hospital	Westerville	Ohio	United States	43081
640	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
641	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
642	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
643	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
644	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
645	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
646	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
647	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
648	Saint Charles Health System	Bend	Oregon	United States	97701
649	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
650	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
651	Bay Area Hospital	Coos Bay	Oregon	United States	97420
652	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
653	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
654	Providence Portland Medical Center	Portland	Oregon	United States	97213
655	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
656	Portland VA Medical Center	Portland	Oregon	United States	97239
657	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
658	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
659	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
660	Chambersburg Hospital	Chambersburg	Pennsylvania	United States	17201
661	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
662	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
663	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
664	Ephrata Community Hospital	Ephrata	Pennsylvania	United States	17522
665	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
666	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
667	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
668	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
669	Sechler Family Cancer Center	Lebanon	Pennsylvania	United States	17042
670	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
671	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
672	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
673	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
674	Community Medical Center	Scranton	Pennsylvania	United States	18510
675	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
676	Geisinger Medical Group	State College	Pennsylvania	United States	16801
677	Reading Hospital	West Reading	Pennsylvania	United States	19611
678	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
679	Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	United States	19090
680	WellSpan Health-York Cancer Center	York	Pennsylvania	United States	17403
681	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
682	Medical University of South Carolina	Charleston	South Carolina	United States	29425
683	Saint Francis Hospital	Greenville	South Carolina	United States	29601
684	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
685	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
686	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
687	Memorial Hospital	Chattanooga	Tennessee	United States	37404
688	Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	United States	38017
689	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
690	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
691	University of Tennessee - Knoxville	Knoxville	Tennessee	United States	37920
692	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
693	Vanderbilt Breast Center at One Hundred Oaks	Nashville	Tennessee	United States	37204
694	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
695	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
696	Hendrick Medical Center	Abilene	Texas	United States	79601
697	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
698	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
699	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
700	Ben Taub General Hospital	Houston	Texas	United States	77030
701	M D Anderson Cancer Center	Houston	Texas	United States	77030
702	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
703	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
704	Logan Regional Hospital	Logan	Utah	United States	84321
705	Intermountain Medical Center	Murray	Utah	United States	84107
706	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
707	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
708	Riverton Hospital	Riverton	Utah	United States	84065
709	Saint George Regional Medical Center	Saint George	Utah	United States	84770
710	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
711	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
712	LDS Hospital	Salt Lake City	Utah	United States	84143
713	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
714	University of Vermont Medical Center	Burlington	Vermont	United States	05401
715	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
716	VCU Massey Cancer Center at Stony Point	Richmond	Virginia	United States	23235
717	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
718	Shenandoah Oncology PC	Winchester	Virginia	United States	22601
719	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
720	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
721	Overlake Medical Center	Bellevue	Washington	United States	98004
722	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
723	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
724	Harrison Medical Center	Bremerton	Washington	United States	98310
725	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
726	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
727	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
728	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
729	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
730	Saint Francis Hospital	Federal Way	Washington	United States	98003
731	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
732	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
733	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
734	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
735	Saint Clare Hospital	Lakewood	Washington	United States	98499
736	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
737	Jefferson Healthcare	Port Townsend	Washington	United States	98368
738	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
739	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
740	Valley Medical Center	Renton	Washington	United States	98055
741	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
742	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
743	Kaiser Permanente Washington	Seattle	Washington	United States	98112
744	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
745	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
746	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
747	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
748	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
749	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
750	MultiCare Deaconess Cancer and Blood Specialty Center - North	Spokane	Washington	United States	99218
751	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
752	Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	United States	98405
753	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
754	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
755	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
756	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
757	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
758	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
759	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
760	Ascension Saint Elizabeth Hospital	Appleton	Wisconsin	United States	54915
761	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
762	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
763	Ascension Southeast Wisconsin Hospital - Elmbrook Campus	Brookfield	Wisconsin	United States	53045
764	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
765	Ascension Calumet Hospital	Chilton	Wisconsin	United States	53014
766	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
767	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
768	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
769	Ascension Saint Francis - Reiman Cancer Center	Franklin	Wisconsin	United States	53132
770	Ascension Southeast Wisconsin Hospital - Franklin	Franklin	Wisconsin	United States	53132
771	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
772	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
773	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
774	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
775	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
776	Essentia Health-Hayward Clinic	Hayward	Wisconsin	United States	54843
777	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
778	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
779	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
780	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
781	Saint Vincent Hospital Cancer Center at Marinette	Marinette	Wisconsin	United States	54143
782	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
783	Aspirus Medford Hospital	Medford	Wisconsin	United States	54451
784	Ascension Columbia Saint Mary's Hospital Ozaukee	Mequon	Wisconsin	United States	53097
785	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
786	Ascension Southeast Wisconsin Hospital - Saint Joseph Campus	Milwaukee	Wisconsin	United States	53210
787	Ascension Columbia Saint Mary's Hospital - Milwaukee	Milwaukee	Wisconsin	United States	53211
788	Ascension Saint Francis Hospital	Milwaukee	Wisconsin	United States	53215
789	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
790	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
791	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
792	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
793	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
794	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
795	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
796	Ascension Mercy Hospital	Oshkosh	Wisconsin	United States	54904
797	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
798	Ascension All Saints Hospital	Racine	Wisconsin	United States	53405
799	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
800	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
801	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
802	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
803	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
804	Essentia Health-Spooner Clinic	Spooner	Wisconsin	United States	54801
805	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
806	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
807	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
808	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
809	Essentia Health Saint Mary's Hospital - Superior	Superior	Wisconsin	United States	54880
810	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
811	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
812	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
813	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
814	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
815	Ascension Medical Group Southeast Wisconsin - Mayfair Road	Wauwatosa	Wisconsin	United States	53226
816	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
817	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
818	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
819	Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	United States	54494
820	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
821	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
822	Billings Clinic-Cody	Cody	Wyoming	United States	82414
823	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Sapna P Patel, Southwest Oncology Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT03698019
• Other Study ID Numbers: NCI-2018-02107; NCI-2018-02107; S1801; S1801; U10CA180888
• First Posted: Oct 5, 2018
• Last Update Posted: Aug 8, 2022
• Last Verified: May 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Melanoma; Skin Neoplasms; Pembrolizumab

Study Results

No Results Posted as of Aug 8, 2022