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Activation of Polyamine Catabolism in Patients With Acute Pancreatitis

Sponsor
Tampere University (Other)
Overall Status
Completed
CT.gov ID
NCT00484042
Collaborator
(none)
17
Duration (Months)

Study Details

Study Description

Brief Summary

Background: Polyamines are essential compounds in all mammalian tissues. If tissue spermidine/spermine levels, however, dramatically decrease, the cellular survival is severely endangered. Transgenic animals, where the homeostasis of cellular polyamines can be disturbed and tissue spermidine/spermine levels are decreased, acute pancreatitis evolves, indicating pancreas to be one of the most vulnerable organs for tissue polyamine catabolism. On the other hand, our own data suggests that also in other models of acute experimental pancreatitis pancreatic polyamines are changed depending on the severity of pancreatitis in such a way that the more severe pancreatitis the lower are the pancreatic polyamine levels. Minor changes were observed also in rats undergoing sham operation only. In addition of pancreatic enzymes, inflammatory mediators are also involved in the pathophysiology of the disease. CRP, IL-6, IL-8, IL-10 and Procalcitonin are useful in predicting the severity of the disease, combination of IL-6 and IL-10 at admission can predict organ failure with sensitivity of 95 %, specificity of 88 %.

Hypothesis: Similar to experimental pancreatitis, blood polyamine changes are associated with acute pancreatitis also in the man. These changes are dependent on the severity of pancreatitis, but not on the etiology of pancreatitis. The changes are specific to acute pancreatitis compared with other intra-abdominal emergencies. The changes observed return to baseline during recovery. Furthermore, we assume that blood polyamine negatively correlates with IL-6, IL-8, and procalcitonin, and positively with IL-10.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Other
    Study Start Date :
    Jan 1, 2006
    Actual Study Completion Date :
    Jun 1, 2007

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 90 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • Patients who are diagnosed as acute pancreatitis.

      • Patients who are diagnosed as either of gallstone, duodenal ulcer or bleeding, gastric ulcer or bleeding, irritable bowel syndrome, hernia, diverticulitis, retrocecal appendicitis with non-pancreatic acute abdominal pain.

      Exclusion Criteria:

      • Patients who underwent operation

      • Patients who underwent recurrent acute pancreatitis

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Tampere University

      Investigators

      • Principal Investigator: Isto H Nordback, M.D., Tampere University Hospital

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00484042
      Other Study ID Numbers:
      • R06025
      First Posted:
      Jun 8, 2007
      Last Update Posted:
      Jun 8, 2007
      Last Verified:
      Jun 1, 2007
      Keywords provided by , ,
      pancreatitis
      polyamine
      cytokine
      Additional relevant MeSH terms:
      Pancreatitis

      Study Results

      No Results Posted as of Jun 8, 2007