Acute, Affective, Organic Disorders.

Sponsor

Norwegian University of Science and Technology (Other)

Overall Status

Completed

CT.gov ID

NCT00201474

Collaborator

St. Olavs Hospital (Other), Dr. Dedichens Institute for Psychiatric Research, Oslo, Norway. (Other), GlaxoSmithKline (Industry)

Enrollment

Location

140

Duration (Months)

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.

Condition or Disease	Intervention/Treatment	Phase
Depressive Disorders

Detailed Description

A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.

In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.

Study Design

Study Type:

Observational

Actual Enrollment :

32 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.

Study Start Date :

Oct 1, 1998

Actual Primary Completion Date :

Oct 1, 2004

Actual Study Completion Date :

Jun 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
brief depressive periods brief depressive periods together with other fluctuating psychiatric symptoms
major depressive disorder

Outcome Measures

Primary Outcome Measures

epilepsy or an other organic brain disorder [1 week]
EEG and QEEG are taken three times in the first week

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Acutely admitted psychiatric patients who have at different times the last 2 weeks filled criteria for at least two new DSM-4 Axis 1 psychiatric diagnoses. One of them has to be a depressive episode (MADRS>20)