MAVASCOR: Markers of Vascular Aging and Coronary Syndrome

• Sponsor: CHU de Reims (Other)
• Overall Status: Completed
• CT.gov ID: NCT02857387
• Collaborator: (none)
• Enrollment: 65
• Location: 1
• Arm: 1
• Actual Duration (Months): 34.9
• Patients Per Site Per Month: 1.9

Study Details

Study Description

Brief Summary

Atherosclerosis and aging are associated to the raise of biochemical alterations of proteins grouped under the name of " non-enzymatic post-translational modifications ". They often correspond to the irreversible binding of glucose or other oses (glycation) or urea derivatives (carbamylation) on proteins and lead to the formation of complex compounds (post-translational modifications derived products, PTMD) that can accumulate in tissues and be responsible for deleterious effects. The specific role of these compounds in the pathophysiology of aging and atherosclerosis remains unknown, as are the molecular and cellular mechanisms implicated.

This project is based on the hypothesis that non-enzymatic post-translational modifications may cause changes in the genesis of complication of coronary atherosclerosis and that PTMD could therefore constitute relevant biomarkers in this specific clinical situation.

To explore these potential new biomarkers, the investigators designed a study in patients having experienced an acute coronary syndrome and followed during a year. The concentrations of PTMD assayed at 0, 1, 3, 12 months, will be correlated to clinical (severity and evolution) and paraclinical (cutaneous autofluorescence) data and the effect of cardiac rehabilitation will be assessed.

This should help to identify new (and non-traditional) biomarkers of coronary heart disease and determine some of the implicated pathophysiological mechanisms.

Condition or Disease	Intervention/Treatment	Phase
Acute Coronary Syndrome	Biological: blood sample withdrawn	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 65 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Markers of Vascular Aging and Coronary Syndrome
• Actual Study Start Date: Oct 1, 2015
• Actual Primary Completion Date: Aug 27, 2018
• Actual Study Completion Date: Aug 27, 2018

Arms and Interventions

Arm	Intervention/Treatment
Experimental: acute coronary syndrome	Biological: blood sample withdrawn

Outcome Measures

Primary Outcome Measures

1. Post-translational modifications of Proteins quantification assessed by Liquid chromatography-mass spectrometry [up to 1 year]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• acute coronary heart syndrome

• included during hospitalization, usual cardiologic follow-up planned in Reims university hospital

Exclusion Criteria:

• <18yo

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Chu Reims	France	Reims	France	51092

Sponsors and Collaborators

• CHU de Reims

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: CHU de Reims
• ClinicalTrials.gov Identifier: NCT02857387
• Other Study ID Numbers: PO15043
• First Posted: Aug 5, 2016
• Last Update Posted: Oct 25, 2018
• Last Verified: Oct 1, 2018

• Additional relevant MeSH terms: Acute Coronary Syndrome; Syndrome

Study Results

No Results Posted as of Oct 25, 2018