Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
Sponsor
Cogentus Pharmaceuticals (Industry)
Overall Status
Terminated
CT.gov ID
NCT00557921
Collaborator
(none)
5,000
491
2
23
10.2
0.4
Study Details
Study Description
Brief Summary
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer disease, in the setting of concomitant aspirin therapy.
Antiplatelet therapy is an essential element of care for patients with atherothrombotic disease. Bleeding is a fundamental adverse effect of all antiplatelet drugs including aspirin, clopidogrel and dual antiplatelet regimens.
The gastrointestinal tract is the most common site of bleeding related to antiplatelet therapy, typically in connection with peptic ulcer disease. Recently published studies suggest the use of clopidogrel carries a gastrointestinal bleeding risk similar to that of aspirin or non-aspirin non-steroidal anti-inflammatory drugs. Patients taking any two of these drugs (clopidogrel, aspirin and/or non-aspirin NSAIDs) are exposed to an even higher risk of bleeding and ulcer disease.
Cogentus Pharmaceuticals is launching phase 3 trials of a novel combination product, CGT-2168, which has the potential to significantly reduce this problem and increase patient safety. CGT-2168 combines a standard dosage of clopidogrel and a gastroprotectant (omeprazole) in a once-daily pill that may reduce the likelihood of adverse gastrointestinal events.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
5000 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease
Study Start Date
:
Dec 1, 2007
Anticipated Primary Completion Date
:
Nov 1, 2009
Anticipated Study Completion Date
:
Nov 1, 2009
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: 1
|
Drug: CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin
(CGT-2168 active and Comparator placebo, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)
|
| Active Comparator: 2
|
Drug: Plavix (clopidogrel 75 mg) and aspirin
(CGT-2168 placebo and Comparator active, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)
|
Outcome Measures
Primary Outcome Measures
- Composite of upper gastrointestinal clinical events, including gastroduodenal bleeding, symptomatic gastroduodenal ulcer, persistent pain with multiple gastric erosions, obstruction or perforation [Anticipated minimum of 48 weeks, up to end of study]
Secondary Outcome Measures
- Composite of gastroduodenal bleeding, symptomatic gastroduodenal ulcer, obstruction or perforation [Anticipated minimum of 48 weeks, up to end of study]
- Composite of gastroduodenal bleeding, obstruction or perforation [Anticipated minimum of 48 weeks, up to end of study]
- Discontinuation of study medication attributed to gastrointestinal signs or symptoms [Anticipated minimum of 48 weeks, up to end of study]
- Gastroesophageal reflux disease, as evidenced by symptomatic endoscopically-confirmed erosive esophagitis [Anticipated minimum of 48 weeks, up to end of study]
- Dyspepsia, defined as an increase of at least ten points on the "pain intensity" component of the SODA instrument from baseline [Anticipated minimum of 48 weeks, up to end of study]
- Occurrence of a cardiovascular event (cardiovascular death, nonfatal myocardial infarction, CABG or PCI, or confirmed ischemic stroke [Anticipated minimum of 48 weeks, up to end of study]
Eligibility Criteria
Criteria
Ages Eligible for Study:
21 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Patients in whom a requirement for clopidogrel therapy with concomitant aspirin is anticipated for at least the next 12 months. Specific conditions that may confer a need for long-term clopidogrel + aspirin therapy may include non-ST segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), ST segment elevation acute MI), or new placement of a coronary artery stent.
-
For women of childbearing potential, negative pregnancy test prior to randomization and agreement to use effective method of birth control during the study.
-
Able to provide written informed consent based on competent mental status.
Exclusion Criteria:
-
Patients currently hospitalized for whom discharge is not anticipated within 48 hours of randomization.
-
Requirement for current or chronic use of a proton pump inhibitor, H2 receptor blocker, sucralfate or misoprostol.
-
Erosive esophagitis, esophageal or gastric variceal disease, or non-endoscopic gastric surgery. Patients with a history of GERD/erosive esophagitis or dyspepsia who do not currently require proton pump blockers will be eligible.
-
Receipt of > 21 days of clopidogrel or another thienopyridine prior to randomization.
-
Oral anticoagulation that cannot be safely discontinued for duration of study.
-
Recent fibrinolytic therapy.
-
Scheduled percutaneous coronary intervention (PCI). Patients may be enrolled upon completion of PCI.
-
Recent (< 30 days prior to randomization) or scheduled coronary artery bypass graft (CABG) surgery.
-
Cardiogenic shock at time of randomization, refractory ventricular arrhythmias, or congestive heart failure (NY Heart Association class IV).
-
Active pathological bleeding or a history of hereditary or acquired hemostatic disorder.
-
History of hemorrhagic stroke, intracranial neoplasm, arteriovenous malformation or aneurysm.
-
Systemic corticosteroids except low-dose oral corticosteroids equivalent to prednisone < or equal to 5 mg/day.
-
Allergy or contraindication to clopidogrel or other thienopyridine drugs, omeprazole or other proton pump inhibitor drugs, aspirin or salicylate derivatives, or other study drug ingredients.
-
Treatment within 30 days prior to randomization with any investigational drug or device including investigational coronary artery stents or currently enrolled in another interventional drug or device study.
-
Women who are pregnant or breastfeeding.
-
Life expectancy less than 12 months.
-
Laboratory abnormality at screening that is clinically significant or outside protocol-allowed limits, or any other condition that precludes participation in the study in the opinion of the Investigator.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Alabama Clinical Research Institute, Inc. (ACRI) | Alexander City | Alabama | United States | 35010 |
| 2 | Alabama Clinical Therapeutics, LLC | Birmingham | Alabama | United States | 35126 |
| 3 | Cardio-Thoracic Surgeons P.C. | Birmingham | Alabama | United States | 35213 |
| 4 | Birmingham Heart Clinic, PC | Birmingham | Alabama | United States | 35235 |
| 5 | John F Simmons , MD PC | Geneva | Alabama | United States | 36340 |
| 6 | Clinical Research Consultants, Inc. | Hoover | Alabama | United States | 35216 |
| 7 | The Heart Center, PC | Huntsville | Alabama | United States | 35801 |
| 8 | Mobile Heart Specialists, PC | Mobile | Alabama | United States | 36608 |
| 9 | Advanced Cardiac Specialists | Mesa | Arizona | United States | 85206 |
| 10 | Redpoint Research | Phoenix | Arizona | United States | 85029 |
| 11 | Cardiovascular Consultants, Ltd. | Phoenix | Arizona | United States | 85032 |
| 12 | Cochise Clinical Research | Sierra Vista | Arizona | United States | 85635 |
| 13 | Paradigm Clinical Research, Inc. | Tucson | Arizona | United States | 85705 |
| 14 | Tri-Lakes Research | Hot Springs | Arkansas | United States | 71901 |
| 15 | Michael A. Frais, Cardiologist, P.A. | Hot Springs | Arkansas | United States | 71913 |
| 16 | NEA-Clinic Cardiology | Jonesboro | Arkansas | United States | 72401 |
| 17 | Searcy Medical Center | Searcy | Arkansas | United States | 72143 |
| 18 | Cardiology Consultants of Orange County | Anaheim | California | United States | 92801 |
| 19 | Chest and Critical Care Consultants, A Medical Group | Anaheim | California | United States | 92801 |
| 20 | Clinical Solutions Advantage | Buena park | California | United States | 90620 |
| 21 | Turns Institute for Clinical Research | Castro Valley | California | United States | 94546 |
| 22 | Escondido Cardiology Associates | Escondido | California | United States | 92025 |
| 23 | Accurate Clinical Trials, Inc. | Laguna Hills | California | United States | 92653 |
| 24 | Therapeutic Research Institute of Orange County | Laguna Hills | California | United States | 92653 |
| 25 | Kirtik Thaker MD | Lakewood | California | United States | 90712 |
| 26 | Los Angeles Cardiology Associates | Los Angeles | California | United States | 90017 |
| 27 | Merced Heart Associates | Merced | California | United States | 95348 |
| 28 | Mission Internal Medical Group | Mission Viejo | California | United States | 92691 |
| 29 | Altos Cardiovascular Associates | Mountain View | California | United States | 94040 |
| 30 | Kenneth W. Carr, MD, Cardiology | Oceanside | California | United States | 92056 |
| 31 | Rancho CucamongaClinical Trials | Rancho Cucamonga | California | United States | 91703 |
| 32 | Inland Heart and Vascular Medical Associates | San Bernardino | California | United States | 92404 |
| 33 | Ritchken and First | San Diego | California | United States | 92117 |
| 34 | Rider Research Group | San Francisco | California | United States | 94117 |
| 35 | Richard Levy, MD. | San Francisco | California | United States | 94118 |
| 36 | Kaiser Permanente | San Jose | California | United States | 95119 |
| 37 | Medical Helping Hands Research | Santa Ana | California | United States | 92704 |
| 38 | Pacific Heart Institute | Santa Monica | California | United States | 90404 |
| 39 | Radiant Research | Santa Rosa | California | United States | 95405 |
| 40 | Harbor- UCLA Medical Center | Torrance | California | United States | 90509 |
| 41 | Ventura Cardiology Consultants Medical Group, Inc. | Ventura | California | United States | 93003 |
| 42 | Colorado Springs Health Partners | Colorado Springs | Colorado | United States | 80907 |
| 43 | Connecticut Clinical Research | Bridgeport | Connecticut | United States | 06606 |
| 44 | Hartford Hospital | Hartford | Connecticut | United States | 06102 |
| 45 | Alfieri Cardiology, PA | Newark | Delaware | United States | 19713 |
| 46 | Washington V.A. Medical Center | Washington | District of Columbia | United States | 20422 |
| 47 | Oscar R. Guerra, MD PA | Coral Gables | Florida | United States | 33134 |
| 48 | Deerfield Beach Cardiology Associates | Deerfield Beach | Florida | United States | 33442 |
| 49 | Dr Jules Cohen | Hallandale | Florida | United States | 33009 |
| 50 | Empire International Research | Hialeah | Florida | United States | 33012 |
| 51 | Cardiovascular Consultants of South Florida | Hollywood | Florida | United States | 33021 |
| 52 | Jacksonville Heart Center | Jacksonville | Florida | United States | 32207 |
| 53 | Jacksonville Center for Clinical Research | Jacksonville | Florida | United States | 32216 |
| 54 | Jacksonville Heart Center | Jacksonville | Florida | United States | 32250 |
| 55 | CVMS Resesarch Institute, LLC | Jupiter | Florida | United States | 33458 |
| 56 | Watson Clinic Center for Research | Lakeland | Florida | United States | 33805 |
| 57 | Alpha Medical Research, LLC | Melbourne | Florida | United States | 32901 |
| 58 | Empire International Research | Miami | Florida | United States | 33125 |
| 59 | Suncoast Research Group, LLC | Miami | Florida | United States | 33144 |
| 60 | Cardiovascular Research Center of South Florida | Miami | Florida | United States | 33173 |
| 61 | Research Center Phase I-IV of Florida Corp. | Miami | Florida | United States | 33175 |
| 62 | Empire International Research | Miami | Florida | United States | 33186 |
| 63 | Bert Fish Medical Center | New Smyrna Beach | Florida | United States | 32168 |
| 64 | Central Florida Cardiology Group | Orlando | Florida | United States | 32803 |
| 65 | Cardiology Assocaites of Orlando d/b/a Orlando Heart Center | Orlando | Florida | United States | 32806 |
| 66 | Sunset Point Medical Associates | Palm Harbor | Florida | United States | 34684 |
| 67 | Berma Research Group | Plantation | Florida | United States | 33317 |
| 68 | Charlotte Heart Group Research Center | Port Charlotte | Florida | United States | 33952 |
| 69 | Suncoast Cardiovascular Research | St. Petersburg | Florida | United States | 33701 |
| 70 | The Heart and Vascular Institute of Florida | St. Petersburg | Florida | United States | 33709 |
| 71 | G&G Research Baker-Tombul Cardiology | Vero Beach | Florida | United States | 32960 |
| 72 | Carlos Levy, D.O. | Weston | Florida | United States | 33326 |
| 73 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 74 | Primary Care Specialists, LLC/ ECAST CT | Atlanta | Georgia | United States | 30312 |
| 75 | Executive Health and Research Associates, Inc. | Atlanta | Georgia | United States | 30342 |
| 76 | Southeast Regional Research Group | Columbus | Georgia | United States | 31904 |
| 77 | Georgia Heart Specialists, LLC | Covington | Georgia | United States | 30014 |
| 78 | Ialum Clinical Research Center, LLC | Decatur | Georgia | United States | 30032 |
| 79 | Ialum Clinical Research Center | Decatur | Georgia | United States | 30032 |
| 80 | Ialum Clinical Research Center | Decatur | Georgia | United States | 30035 |
| 81 | Southeast Regional Research Group | Savannah | Georgia | United States | 31406 |
| 82 | Medsouth Primary CareStockbridge | Stockbridge | Georgia | United States | 30281 |
| 83 | South Suburban Health Professional Group, PC | Flossmoor | Illinois | United States | 60422 |
| 84 | Consultants in Cardiovascular Medicine | Melrose Park | Illinois | United States | 60160 |
| 85 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61606 |
| 86 | Community Clinical Research Center | Anderson | Indiana | United States | 46011 |
| 87 | American Health Network | Avon | Indiana | United States | 46123 |
| 88 | Indiana Medical Research | Elkhart | Indiana | United States | 46514 |
| 89 | Welborn Clinic | Evansville | Indiana | United States | 47713 |
| 90 | Indiana Heart Physicians | Indianapolis | Indiana | United States | 46237 |
| 91 | Midwest Cardiovascular Research Foundation | Davenport | Iowa | United States | 52803 |
| 92 | Northeast Iowa Medical Education Foundation | Waterloo | Iowa | United States | 50702 |
| 93 | Hutchinson Clinic, P.A. | Hutchinson | Kansas | United States | 67502 |
| 94 | Venture Resource Group, Inc. | Mission | Kansas | United States | 66202 |
| 95 | Midwest Cardiology Assocaites | Overland Park | Kansas | United States | 66209 |
| 96 | Cumberland Cardiology | Ashland | Kentucky | United States | 41101 |
| 97 | Trover Health System | Madisonville | Kentucky | United States | 42431 |
| 98 | Owensboro Heart and Vascular | Owensboro | Kentucky | United States | 42303 |
| 99 | Dolby Research, LLC | Baton Rouge | Louisiana | United States | 33437 |
| 100 | Cardiovascular Institute of the South | Houma | Louisiana | United States | 70301 |
| 101 | Heart Clinic of Louisiana Clinical Research, LLC. | Marrero | Louisiana | United States | 70072 |
| 102 | Maine Research Associates | Auburn | Maine | United States | 04210 |
| 103 | Cardiovascular Consultants of Maine, PA | Scarborough | Maine | United States | 04074 |
| 104 | Maine Cardiology Associates | South Portland | Maine | United States | 04106 |
| 105 | Good Samaritan Hospital (Medstar Health) | Baltimore | Maryland | United States | 21239 |
| 106 | eCast Corporation | Greenbelt | Maryland | United States | 20770 |
| 107 | Atlantic Cardiology Associates, P.A | Salisbury | Maryland | United States | 21801 |
| 108 | Peninsula Cardiology Associates | Salisbury | Maryland | United States | 21804 |
| 109 | Pentucket Medical Associates | Haverhill | Massachusetts | United States | 01830 |
| 110 | Charles River Medical Associates | Natick | Massachusetts | United States | 01760 |
| 111 | Michigan Cardiovascular Institute | Bay City | Michigan | United States | 48708 |
| 112 | Apex Medical Research, AMR, Inc. | Flint | Michigan | United States | 48504 |
| 113 | Borgess Research Institute | Kalamazoo | Michigan | United States | 49048 |
| 114 | Michigan Cardiovascular Institute | Midland | Michigan | United States | 48670 |
| 115 | Michigan Cardiovascular Institute | Saginaw | Michigan | United States | 48601 |
| 116 | Covenant Medical Center, Inc. | Saginaw | Michigan | United States | 48602 |
| 117 | Academic Heart and Vascular PLLC | St. Clair Shores | Michigan | United States | 48081 |
| 118 | Oakland Medical Center | Troy | Michigan | United States | 48085 |
| 119 | Waterford Medical Assoc. P.C. | Waterford | Michigan | United States | 48328 |
| 120 | Michigan Heart, PC | Ypsilanti | Michigan | United States | 48106 |
| 121 | Duluth Clinic / Saint Marys Medical Center | Duluth | Minnesota | United States | 55805 |
| 122 | University of Minnesota | Minneapolis | Minnesota | United States | 55455 |
| 123 | Regions Hospital | St. Paul | Minnesota | United States | 55101 |
| 124 | New Coast Cardiology Center, PLLC | Gulfport | Mississippi | United States | 39503 |
| 125 | PPS Clinical Research, STL, LLC | Chesterfield | Missouri | United States | 63017 |
| 126 | Kansas City VA Medical Center | Kansas City | Missouri | United States | 64128 |
| 127 | Cardiology Diagnostics, Ltd. | St. Louis | Missouri | United States | 63122 |
| 128 | Glacier View Cardiology | Kalispell | Montana | United States | 59901 |
| 129 | Saint Patrick Hospital- International Heart Institute of Montana | Missoula | Montana | United States | 59802 |
| 130 | The Creighton Cardiac Center | Omaha | Nebraska | United States | 68131 |
| 131 | Alegent Health Clinic Heart and Vascular Specialist | Papillion | Nebraska | United States | 68046 |
| 132 | Nevada Cardiology Associates | Las Vegas | Nevada | United States | 89128 |
| 133 | Lahey Cardiology @ the Medical Center | Nashua | New Hampshire | United States | 03060 |
| 134 | Associated Cardiovascular Consultants | Cherry Hill | New Jersey | United States | 08034 |
| 135 | Cardiovascular Associates of the Delaware Valley, P.A. | Elmer | New Jersey | United States | 08318 |
| 136 | Cardiovascular Associates of the Delaware Valley, P.A. | Haddon Heights | New Jersey | United States | 08035 |
| 137 | Cardiovascular Associates of the Delaware Valley, P.A. | Sewell | New Jersey | United States | 08080 |
| 138 | Physicans Research Center, LLC | Toms River | New Jersey | United States | 08755 |
| 139 | Capital Cardiology Associates | Albany | New York | United States | 12211 |
| 140 | Cardiac Care and Vascular Medicine, Albert Einstein College of Medicine | Bronx | New York | United States | 10469 |
| 141 | Hudson Valley Cardiology Group, P.C. | Cortlandt Manor | New York | United States | 10567 |
| 142 | Cardiology Associates, P.C. | Johnson City | New York | United States | 13790 |
| 143 | Long Island Heart Associates | Mineola | New York | United States | 11501 |
| 144 | Slocum-Dickson Medical Group, PLLC | New Hartford | New York | United States | 13413 |
| 145 | Sound Shore Cardiology, P.C. | New Rochelle | New York | United States | 10801 |
| 146 | New York Cardiovascular Associate | New York | New York | United States | 10001 |
| 147 | St. Luke's- Roosevelt Hospital | New York | New York | United States | 10025 |
| 148 | Rochester General Hospital | Rochester | New York | United States | 14621 |
| 149 | Saratoga Cardiology Assoc, PC | Saratoga Springs | New York | United States | 12866 |
| 150 | Westchester Cardiology Associates | Scarsdale | New York | United States | 10583 |
| 151 | Good Samaritan Hospital | Suffern | New York | United States | 10901 |
| 152 | Cardiology, PC | Syracuse | New York | United States | 13210 |
| 153 | SUNY Upstate Medical University | Syracuse | New York | United States | 13210 |
| 154 | Capital Cardiology Associates | Troy | New York | United States | 12180 |
| 155 | Buffalo Cardiology and Pulmonary Associates | Williamsville | New York | United States | 14221 |
| 156 | Mark J. Kozinn, MD | Williamsville | New York | United States | 14221 |
| 157 | Clinical Study Center of Asheville, LLC | Asheville | North Carolina | United States | 28803 |
| 158 | Kernodle Clinic, Inc. | Burlington | North Carolina | United States | 27215 |
| 159 | Metrolina Medical Research | Charlotte | North Carolina | United States | 28209 |
| 160 | Diversified Research | Durham | North Carolina | United States | 27704 |
| 161 | Cumberland Research Associates, LLC | Fayetteville | North Carolina | United States | 28304 |
| 162 | Cardiovascular Care of Northern Carolina | Oxford | North Carolina | United States | 27565 |
| 163 | St. Alexius Medical Center | Bismarck | North Dakota | United States | 58501 |
| 164 | Altru Health Systems | Grand Forks | North Dakota | United States | 58201 |
| 165 | Trinity Health | Minot | North Dakota | United States | 58701 |
| 166 | George G. Ellis, Jr. M.D., Inc. | Boardman | Ohio | United States | 44512 |
| 167 | Cardiovascular Research Institute, LLC | Canton | Ohio | United States | 44710 |
| 168 | Comprehensive Cardiology Consultants, Inc. | Cincinnati | Ohio | United States | 45236 |
| 169 | Midwest Cardiology Research Foundation | Columbus | Ohio | United States | 43214 |
| 170 | Prestige Clinical Research | Franklin | Ohio | United States | 45005 |
| 171 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 172 | Cardiology Associates of SE Ohio, Inc | Zanesville | Ohio | United States | 43701 |
| 173 | Physicans Research, Inc. | Zanesville | Ohio | United States | 43701 |
| 174 | Bluestem Cardiology Research Dept. | Bartlesville | Oklahoma | United States | 74006 |
| 175 | Oklahoma Cardiovascular Research Group | Oklahoma City | Oklahoma | United States | 73109 |
| 176 | Aquilo Research | Yukon | Oklahoma | United States | 73099 |
| 177 | Bend Memorial Clinic | Bend | Oregon | United States | 97701 |
| 178 | Hillsboro Cardiology, PC | Hillsboro | Oregon | United States | 97123 |
| 179 | Legacy Clinical Research | Portland | Oregon | United States | 97210 |
| 180 | Abington Medical Specialists | Abington | Pennsylvania | United States | 19001 |
| 181 | Tri-State Medical Group | Beaver | Pennsylvania | United States | 15009 |
| 182 | Heritage Cardiology Association | Camp Hill | Pennsylvania | United States | 17011 |
| 183 | Premier Heart Specialists | Easton | Pennsylvania | United States | 18042 |
| 184 | Heart Specialists of Lancaster | Ephrata | Pennsylvania | United States | 17522 |
| 185 | Penn State Hershey Medical Center | Hershey | Pennsylvania | United States | 17033 |
| 186 | Pennsylvania Heart and Vascular Group, P.C. | Jenkintown | Pennsylvania | United States | 19046 |
| 187 | Comprehensive Cardiology Consultants | Langhorne | Pennsylvania | United States | 19047 |
| 188 | Sewickley Valley Medical Group Cardiology | Leetsdale | Pennsylvania | United States | 15056 |
| 189 | Cardiology Consultants of Philadelphia | Norristown | Pennsylvania | United States | 19401 |
| 190 | Hospital of the University of Pennsylvania Cardiology Department | Philadelphia | Pennsylvania | United States | 19104 |
| 191 | Cardiology Consultants of Philadelphia | Philadelphia | Pennsylvania | United States | 19111 |
| 192 | Albert Einstein Medical Center | Philadelphia | Pennsylvania | United States | 19141 |
| 193 | Cardiology Consultants of Philadelphia | Philadelphia | Pennsylvania | United States | 19148 |
| 194 | VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | United States | 15240 |
| 195 | Advanced Cardiology Specialists | Scranton | Pennsylvania | United States | 18501 |
| 196 | Elite Medical Research, Inc. | Sellersville | Pennsylvania | United States | 18960 |
| 197 | Cardiology Consultants of Philadelphia | Upland | Pennsylvania | United States | 19013 |
| 198 | West Chester Cardiology, PC | West Chester | Pennsylvania | United States | 19380 |
| 199 | Berks Cardiology, Ltd. | Wyomissing | Pennsylvania | United States | 19610 |
| 200 | Cardiology Consultants of Philadelphia | Yardley | Pennsylvania | United States | 19067 |
| 201 | New England Center for Clinical Research, Inc | Cranston | Rhode Island | United States | 02920 |
| 202 | Rhode Island Hospital Cardiology | Providence | Rhode Island | United States | 02903 |
| 203 | Cardiology Specialists | Westerly | Rhode Island | United States | 02891 |
| 204 | Palmetto Clinical Research | Summerville | South Carolina | United States | 29485 |
| 205 | McMinn Medical Group (DBA: Athens Medical Group) | Athens | Tennessee | United States | 37303 |
| 206 | Verzosa & Ungab Internal Medicine Associates | Bartlett | Tennessee | United States | 38134 |
| 207 | Middle Tennessee Clinical Research | Fayetteville | Tennessee | United States | 37334 |
| 208 | Research Associates of Jackson and Apex Cardiology | Jackson | Tennessee | United States | 38301 |
| 209 | Tri-State Cardiology | Johnson City | Tennessee | United States | 37601 |
| 210 | Memphis Internal Medicine | Memphis | Tennessee | United States | 38119 |
| 211 | Goodlife Medical Center | Memphis | Tennessee | United States | 38120 |
| 212 | Heart and Vascular Clinic | Nashville | Tennessee | United States | 37203 |
| 213 | Family Health Care Assoc. | Arlington | Texas | United States | 76013 |
| 214 | Southeast Texas Clinical Research Center | Beaumont | Texas | United States | 77702 |
| 215 | Trinity Hypertension and Diagnostic Res. | Carrollton | Texas | United States | 75006 |
| 216 | VA Medical Center | Dallas | Texas | United States | 75216 |
| 217 | U.T. Southwestern | Dallas | Texas | United States | 75390 |
| 218 | Amir Malik Research | Fort Worth | Texas | United States | 76104 |
| 219 | The University of Texas Medical Branch at Galveston | Galveston | Texas | United States | 77555-0553 |
| 220 | East Texas Cardiology PA | Houston | Texas | United States | 77002 |
| 221 | Office of Amer Zaheer, MD | Houston | Texas | United States | 77004 |
| 222 | Office of Salim Gopalani, MD | Houston | Texas | United States | 77008 |
| 223 | Comprehensive Heart Care, PA | Houston | Texas | United States | 77024 |
| 224 | Century Clinical Research | Houston | Texas | United States | 77036 |
| 225 | Office of Mizra Basith Baig, MD | Houston | Texas | United States | 77055 |
| 226 | Covenant Cardiology Associates | Lubbock | Texas | United States | 79410 |
| 227 | South Texas Institutes of Health | Mcallen | Texas | United States | 78572 |
| 228 | Texas Regional Heart Center d/b/a Legacy Heart Center | Plano | Texas | United States | 75024 |
| 229 | Heart & Vascular Institute of Texas | San Antonio | Texas | United States | 78217 |
| 230 | Cardiology Clinic of San Antonio | San Antonio | Texas | United States | 78229 |
| 231 | South Texas Cardiovascular Consultants | San Antonio | Texas | United States | 78229 |
| 232 | IMED Research, PA | San Antonio | Texas | United States | 78258 |
| 233 | Southwest Health Associate, PA | Sugar Land | Texas | United States | 77478 |
| 234 | Office of Dwayne O. Williams, MD | Sugarland | Texas | United States | 77479 |
| 235 | Kings Daughters Clinic | Temple | Texas | United States | 76502 |
| 236 | Victoria Heart and Vascular Center | Victoria | Texas | United States | 77901 |
| 237 | Cardiology Consultants of Danville | Danville | Virginia | United States | 24541 |
| 238 | Triad Research Institute | Galax | Virginia | United States | 24333 |
| 239 | Virginia Cardiovascular Specialists | Richmond | Virginia | United States | 23226 |
| 240 | Winchester Medical Center/ Clinical Research Department | Winchester | Virginia | United States | 22601 |
| 241 | Daniel W. Gottlieb, MD, PS | Burien | Washington | United States | 98166 |
| 242 | Heart Clinic Northwest | Spokane | Washington | United States | 99204 |
| 243 | Inland Cardiology Assocaites | Spokane | Washington | United States | 99204 |
| 244 | Franciscan Health System dba FHS Research Center | Tacoma | Washington | United States | 98405 |
| 245 | Parkersburg Cardiology Associates | Parkersburg | West Virginia | United States | 26101 |
| 246 | Wisconsin Heart, S.C. | Madison | Wisconsin | United States | 53715 |
| 247 | Heart Care Associates, LLC | Milwaukee | Wisconsin | United States | 53215 |
| 248 | The Canberra Hospital | Garran | Australian Capital Territory | Australia | 2605 |
| 249 | Coffs Harbour Cardiology | Coffs Harbour | New South Wales | Australia | 2450 |
| 250 | Cardiac Research Institute | Eastwood | New South Wales | Australia | 2122 |
| 251 | Wesley research institute | Auchenflower | Queensland | Australia | 4066 |
| 252 | Cairns Base Hospital | Cairns | Queensland | Australia | 4870 |
| 253 | Royal Brisbane and Women's Hospital | Herston | Queensland | Australia | 4029 |
| 254 | Royal Hobart Hospital | Hobart | Tasmania | Australia | 7001 |
| 255 | Launceston General Hospital | Launceston | Tasmania | Australia | 7250 |
| 256 | Northern Hospital | Epping | Victoria | Australia | 3076 |
| 257 | St.Vincent's Hospital (Melb) | Fitzroy | Victoria | Australia | 3065 |
| 258 | Geelong Hospital- Barwon Health | Geelong | Victoria | Australia | 3220 |
| 259 | Fremantle Hospital | Fremantle | Western Australia | Australia | 6160 |
| 260 | Multiprofile Hospital for Active Treatment "Sveta Ekaterina", 1st Department of Internal Diseases | Dimitrovgrad | Bulgaria | ||
| 261 | Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski, Clinic of Cardiology | Pleven | Bulgaria | ||
| 262 | Multiprofile Hospital for Active Treatment ''Sveti Georgi'', Cardiology Clinic | Plovdiv | Bulgaria | ||
| 263 | Multiprofile Hospital for Active Treatment ''Sveti Panteleymon'', 2nd Department. of Internal Diseases - Intensive Cardiology Unit | Plovdiv | Bulgaria | ||
| 264 | Multiprofile Hospital for Active Treatment - Ruse, 4th Department of Internal Diseases | Rousse | Bulgaria | ||
| 265 | 4th Multiprofile Hospital for Active Treatment | Sofia | Bulgaria | ||
| 266 | Military Medical Academy, Clinic of Cardiology and Intensive Care | Sofia | Bulgaria | ||
| 267 | Multiprofile Hospital for Active Treatment and Emergency Medicine "Pirogov". Cardiology Clinic | Sofia | Bulgaria | ||
| 268 | National Heart Hospital Department of Cardiology | Sofia | Bulgaria | ||
| 269 | National Multiprofile Transport Hospital "Tsar Boris III, Cardiology Clinic | Sofia | Bulgaria | ||
| 270 | Tokuda Hospital Department of Cardiology | Sofia | Bulgaria | ||
| 271 | University Multiprofile Hospital for Active Treatment ''Tsaritsa Ioanna'' - ISUL, Cardiology Clinic | Sofia | Bulgaria | ||
| 272 | Multiprofile Hospital for Active Treatment "Sveta Marina", Clinic of Internal Diseases - 2nd Internal Department | Varna | Bulgaria | ||
| 273 | Dr. Tsui | Maple Ridge | British Columbia | Canada | V2X 5Z6 |
| 274 | Fraser Clinical Trials Inc and Royal Columbian Hospital | New Westminster | British Columbia | Canada | V3L3W4 |
| 275 | Vancouver General Hospital | Vancouver | British Columbia | Canada | V5Z 1M9 |
| 276 | Victoria Heart Institute Foundation | Victoria | British Columbia | Canada | V8R4R2 |
| 277 | Health Sciences Centre | Winnipeg | Manitoba | Canada | R3A1R9 |
| 278 | South East Regional Health Authority | Moncton | New Brunswick | Canada | E1C4B7 |
| 279 | Commonwealth Medical Clinic | Mount Pearl | Newfoundland and Labrador | Canada | A1N1W7 |
| 280 | Cambridge Cardiac Care Centre | Cambridge | Ontario | Canada | NIR-6V6 |
| 281 | Mississauga Clinical Research Center | Mississauga | Ontario | Canada | L5B2P7 |
| 282 | Dr. George Zimakas | Niagara Falls | Ontario | Canada | L2G5X7 |
| 283 | Dr. James Y. Cha | Oshawa | Ontario | Canada | L1J2K1 |
| 284 | Curans Health Center | Thunder Bay | Ontario | Canada | P7R2Z3 |
| 285 | Toronto East Cardiology Associates Inc. | Toronto | Ontario | Canada | M4C-1N2 |
| 286 | Recherches Cliniques Theradev | Granby | Quebec | Canada | J2G8Z9 |
| 287 | ViaCar Recherche Clinique Inc. | Greenfield Park | Quebec | Canada | J4N1L6 |
| 288 | ViaCar Recherche Clinique Inc | Longueuil | Quebec | Canada | J4N1L6 |
| 289 | Hospitalier de l'Universite de Montreal Hotel Dieu | Montreal | Quebec | Canada | H2W 1T8 |
| 290 | Sacre-Coeur Hospital | Montreal | Quebec | Canada | H4J1C5 |
| 291 | Centre de Sante et de services sociaux du nord de lanaudiere/CHRDL | St. Charles-Borromee | Quebec | Canada | J6E6J2 |
| 292 | Centre Hospitalier Beauce-Etchemin | St. George | Quebec | Canada | G5Y5B7 |
| 293 | Clinique de Cardiologie de Trois-Rivieres | Trois Rivieres | Quebec | Canada | G8Z 3R9 |
| 294 | Cardiology and Research | Westmount | Quebec | Canada | H3Z2M6 |
| 295 | Centre Hospitalier Universitaire de Quebec (CHOQ) Hotel Dieu de Quebec | Quebec | Canada | G1R2J6 | |
| 296 | Laval Hospital | Quebec | Canada | G1V4G5 | |
| 297 | Clinica Antofagasta | Antofagasta | Chile | ||
| 298 | Corporación de Beneficencia Osorno | Osorno | Chile | ||
| 299 | Hospital Regional de Punta Arenas Dr. Lautaro Navarro | Punta Arenas | Chile | ||
| 300 | Complejo Asistencial Dr.Sótero del Río | Santiago | Chile | 8207257 | |
| 301 | Hospital del Salvador | Santiago | Chile | ||
| 302 | Instituto Nacional del Tórax | Santiago | Chile | ||
| 303 | Centro de Estudios Cardiovascular | Temuco | Chile | ||
| 304 | Clínica Reñaca | Viña del Mar | Chile | ||
| 305 | Hospital Dr. Gustavo Fricke | Viña del Mar | Chile | ||
| 306 | Hospital Naval Almirante Neff | Viña del Mar | Chile | ||
| 307 | Nemocnice ve Frydku-Mistku | Frydek-Mistek | Czech Republic | 738 18 | |
| 308 | Fakultni nemocnice Hradec Kralove | Hradec Kralove | Czech Republic | 500 05 | |
| 309 | Krajska nemocnice Liberec, a. s. | Liberec | Czech Republic | 460 63 | |
| 310 | Litomyslska nemocnice a. s. | Litomysl | Czech Republic | 570 14 | |
| 311 | Kardiologicka a angiologicka ambulance | Ostrava Vítkovice | Czech Republic | 703 00 | |
| 312 | Kardiologická ambulance | Ostrava | Czech Republic | 702 00 | |
| 313 | Pardubicka krajska nemocnice, a.s. | Pardubice | Czech Republic | 532 03 | |
| 314 | II.interni klinika kardiologie a angiologie 1. LF UK a VFN v Praze | Praha 2 | Czech Republic | 12808 | |
| 315 | Klinika kardiologie Institut klinické a experimentální medicíny | Praha 4 | Czech Republic | 140 21 | |
| 316 | Krajská nemocnice T. Bati a.s. | Zlín | Czech Republic | 762 75 | |
| 317 | Nemocnice Znojmo, p.o. | Znojmo | Czech Republic | 669 02 | |
| 318 | Centre Hospitalier d'Albi | Albi | France | 81000 | |
| 319 | Centre de Cardiologie CHRU Dijon | Dijon Cedex | France | 21079 | |
| 320 | Clinique Pasteur | Essey les Nancy Cedex | France | 54270 | |
| 321 | CHRU de Lille Hôpital Cardiologique | Lille Cedex | France | 59037 | |
| 322 | Hôpital La Timone-Adultes | Marseille | France | 13385 | |
| 323 | La Pitié Salpétrière Institut de Cardiologie | Paris Cedex 13 | France | 75651 | |
| 324 | Hôpital Lariboisière | Paris | France | 75010 | |
| 325 | Centre Hospitalier Intercommunal du Val d'Ariège | St Jean de Verges | France | 09000 | |
| 326 | Centre Hospitalier Rangueil Larrey | Toulouse Cedex 4 | France | 31403 | |
| 327 | Universitatsklinikum Berlin Campus Charite Mitte Med Klinik Kardiologie und Angiologie | Berlin | Germany | 10117 | |
| 328 | Vivantes Clinic Neuköln Berlin | Berlin | Germany | 12351 | |
| 329 | Vivantes Humbolt Klinikum | Berlin | Germany | 13509 | |
| 330 | Praxis Dr. med. Boscher | Biberach | Germany | 88400 | |
| 331 | St. Josef-Hospital Medizinische Klinik II, Kardiologie | Bochum | Germany | 44791 | |
| 332 | Dr. THomas Klingenheben | Bonn-Lengsdorf | Germany | 53127 | |
| 333 | St.-Marien-Hospital Bonn | Bonn | Germany | 53115 | |
| 334 | Städtisches Klinikum Brandenburg GmbH | Brandenburg | Germany | 14770 | |
| 335 | MVZ am Küchwald GmbH | Chemnitz | Germany | 09113 | |
| 336 | Gemeinschaftspraxis Innere Medizin und Kardiologie | Dinslaken | Germany | 46535 | |
| 337 | St.-Johannes-Hospital Dortmund | Dortmund | Germany | 44137 | |
| 338 | Zentrum für klinische Prüfungen in der Facharztzentrum Dresden Neustadt GbR | Dresden | Germany | 1099 | |
| 339 | Practice of Cardiology | Erfurt | Germany | 990804 | |
| 340 | Elisabeth.Krankenhaus | Essen | Germany | 45138 | |
| 341 | Asklepios Klinik St.Georg | Hamburg | Germany | 20099 | |
| 342 | Asklepios Klinik Barmbek | Hamburg | Germany | 22291 | |
| 343 | Universitäres Herz-und Gefäßzentrum Hamburg" | Hamburg | Germany | 22527 | |
| 344 | Kardiologische Praxis Hamburg Altona | Hamburg | Germany | 22765 | |
| 345 | Klinikum Region Hannover Krankenhaus Nordstadt | Hannover | Germany | 30167 | |
| 346 | Kardiologische Gemeinschaftspraxis | Hartmannsdorf | Germany | 09232 | |
| 347 | SRH Klinikum Karlsbad-Langensteinbach | Karlsbad | Germany | 76307 | |
| 348 | Kliniken der Stadt Köln, Köln Merheim | Koln | Germany | 53109 | |
| 349 | Herzzentrum Lahr | Lahr | Germany | 77933 | |
| 350 | Kardiologische Gemeinschaftpraxis | Leipzig | Germany | 04103 | |
| 351 | Universität Leipzig - Herzzentrum | Leipzig | Germany | 04289 | |
| 352 | Praxis für Innere Medizin, Gastroenterologie | Ludwigshafen | Germany | 67067 | |
| 353 | Universitätsklinikum Lübeck | Lübeck | Germany | 23538 | |
| 354 | Gemeinschaftspraxis | Lüneburg | Germany | 21339 | |
| 355 | Klinikum der Johannes-Gutenberg-Universität | Mainz | Germany | 55131 | |
| 356 | Gemeinschaftspraxis | Mannheim | Germany | 68165 | |
| 357 | Klinikum Mannheim GmbH, Universaitatskinikum | Mannheim | Germany | 68167 | |
| 358 | Kardiologische Praxis | Markkleeberg | Germany | 04416 | |
| 359 | Asklepios Klinik Melsungen | Melsungen | Germany | 34212 | |
| 360 | Kilniken Maria Hilf GmbH Krankenhaus St. Franziskus | Mönchengladbach | Germany | 41063 | |
| 361 | Internist/Kardiologe/Angiologe | Mühldorf a.d. Inn | Germany | 84453 | |
| 362 | Kardiologische Gemeinschaftspraxis | Nienburg | Germany | 31582 | |
| 363 | Klinikum Pirna GmbH | Pirna | Germany | 01796 | |
| 364 | Universitätsklinik Regensburg | Regensburg | Germany | 93053 | |
| 365 | Krankenhaus Reinbek St. Adolf-Stift | Reinbek | Germany | 21465 | |
| 366 | Kardiologische Gemeinschaftspraxis | Riesa | Germany | 01589 | |
| 367 | Internistische Praxis | Rottweil | Germany | 78628 | |
| 368 | Zentrum für Prävention und Rehabilation | Siegen | Germany | 57072 | |
| 369 | Marienkrankenhaus Soest | Soest | Germany | 59494 | |
| 370 | Praxisgemeinschaft Stuhr-Brinkum | Stuhr | Germany | 28816 | |
| 371 | Medizinische Universitätsklinik | Tubingen | Germany | 72076 | |
| 372 | Josephs-Hospital Warendorf | Warendorf | Germany | 48231 | |
| 373 | Kardiologische Praxis | Wermsdorf | Germany | 04779 | |
| 374 | Dr. Andreas Schreckenberg | Weyhe-Leeste | Germany | 28844 | |
| 375 | ForschungsZentrum Ruhr | Witten | Germany | 58455 | |
| 376 | Helios Klinikum Wuppertal | Wuppertal | Germany | 42117 | |
| 377 | Bajai Kórház | Baja | Hungary | H-6500 | |
| 378 | Budai Irgalmasrendi Kórház | Budapest | Hungary | H-1027 | |
| 379 | Fővárosi Önkormányzat Károlyi Sándor Kórház és Rendelőintézet | Budapest | Hungary | H-1041 | |
| 380 | Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo Korhaz - Rendelointezet | Budapest | Hungary | H-1096 | |
| 381 | Városi Önkormányzat Kórház-Rendelőintézet | Kalocsa | Hungary | H-6300 | |
| 382 | Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András Oktató Kórház | Nyíregyháza | Hungary | H-4400 | |
| 383 | Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház | Toszegi | Hungary | H-5004 | |
| 384 | Jávorszky Ödön Kórház | Vác | Hungary | H-2600 | |
| 385 | Zala Megyei Kórház | Zalaegerszeg | Hungary | H-8900 | |
| 386 | Ospedali Riuniti di bergamo | Bergamo | Italy | 24128 | |
| 387 | Azienda Ospedaliera della Provincia di Lodi Presidio Ospedaliero di Codogno | Codogno (Lodi) | Italy | 26845 | |
| 388 | Azienda Ospedaliera Universitaria San Martino-Dipartimento di Medicina Interna e Specialità Mediche | Genova | Italy | 16132 | |
| 389 | Azienda Ospeedaliera Carlo Poma | Mantova | Italy | 46100 | |
| 390 | Azienda Ospedaliera Maggiore Della Carita' Di Novara | Novara | Italy | 28100 | |
| 391 | Istituto Clinico Humanitas | Rozzano (Milano) | Italy | 20089 | |
| 392 | Hospital "Valentín Gómez Farías" | Guadalajara | Jalisco | Mexico | 44600 |
| 393 | Cardioarritmias e Investigación, S.C. | San Luis Potosi | San Lusi Potosi | Mexico | 78200 |
| 394 | Hospital Cardiológica Aguascalientes | Aguascalientes | Mexico | 20230 | |
| 395 | Hospital de Jesus | D. F. | Mexico | cp 06090 | |
| 396 | Cardioprevent | Durango | Mexico | C. P 34080 | |
| 397 | Hospital Angeles de Puebla | Puebla | Mexico | 72190' | |
| 398 | Hospital General de Puebla | Puebla | Mexico | 72490 | |
| 399 | Instituto de Corazón de Querétaro, S.A. de C.V. | Queretaro | Mexico | 76178 | |
| 400 | Hospital Central "Dr. Ignacio Morones Prieto" | San Luis Potosi | Mexico | 78240 | |
| 401 | Oddział Kardiologii z Zakładem Diagnostyki Kardiologicznej, Samodzielny Publiczny Zakład Opieki Zdrowotnej, Wojewódzki Szpital im. dr J. Biziela, | Bydgoszcz | Poland | 85-168 | |
| 402 | NZOZ "Medicus" Jacek Kubica | Bydgoszcz | Poland | 85-435 | |
| 403 | Wojewódzki Szpital Meijski im. Biziela, Oddział Kardiologii - SPZOZ | Bydgoszcz | Poland | 85-826 | |
| 404 | Oddział Chorób Wewnętrzych i Kardiologii , ZOZ w Debicy | Dębica | Poland | 39-200 | |
| 405 | Zakład Opieki Zdrowotnej Trójmiejskie Centrum Medyczne Sp. z o.o | Gdańsk | Poland | 80-437 | |
| 406 | Gabinet Kardiologiczny Medipuls | Gdynia | Poland | 81-423 | |
| 407 | Gabinet Kardiologiczno-Internistyczny | Gdynia | Poland | 81-472 | |
| 408 | Centrum Leczenia Chorób Cywilizacyjnych Oddz. Gdynia filla Fikakowo | Gdynia | Poland | 81-572 | |
| 409 | NZOZ Medicus, Poradnia Kardiologiczna | Gliwice | Poland | 44-100 | |
| 410 | Oddział Kardiologii i INK, SPZOZ nr 1 | Gliwice | Poland | 44-100 | |
| 411 | Mazowieckie Centrum Badań Klinicznych Iwona Czajkowska, Monika Śmietańska s.c. | Grodzisk Mazowiecki | Poland | 05-825 | |
| 412 | Publiczny Specjalistyczny Zaklad Opieki Zdrowotnej Oddzial Kardiologiczny | Inowroclaw | Poland | 88-100 | |
| 413 | Oddział Chorób Wewnętrznych i Farmakologii Klinicznej Samodzielny Publiczny Centralny Szpital Kliniczny im. Prof. Kornela Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach | Katowice | Poland | 40-752 | |
| 414 | Szpital Specjalistyczny w Kościerzynie, Oddział Kardiologii | Kościerzyna | Poland | 83-400 | |
| 415 | Oddział Kardiologii, Szpital Specjalistyczny im. J. Dietla | Krakow | Poland | 31-121 | |
| 416 | "Klinika Choroby Wieńcowej Instytut Kardiologii, Collegium Medicum Uniwerytet Jagielloński | Krakow | Poland | 31-202 | |
| 417 | Oddzial Chorób Wewnętrznych III Szpital Specjalistyczny im.Stefana Zeromskiego, SPZOZ w Krakowie | Kraków | Poland | 31-913 | |
| 418 | Niepubliczny Zakład Opieki Zdrowotnej Specjalista Sp. z o.o. | Kutno | Poland | 99-300 | |
| 419 | Poradnia Kardiologiczna, Oddział Chorob Wewnetrznych Szpital Powiatowy w Limanowej | Limanowa | Poland | 34-600 | |
| 420 | Oddział Internistyczno-Kardiologiczny Samodzielny Publiczny Zakład Opieki Zdrowotnej | Lubartów | Poland | 21-100 | |
| 421 | "Oddzial Chorob Wewnetrznych i Kardiologii, Szpital Powiatowy im.Edmunda Biernackiego | Mielec | Poland | 39-300 | |
| 422 | Oddział Kardiologii, Nowa Sól | Nowa Sól | Poland | 67-100 | |
| 423 | ZOZ w Oławie, Oddział Chorób Wewnętrznych | Olawa | Poland | 55-200 | |
| 424 | "Oddział Kardiologiczno-Internistyczny | Olsztyn | Poland | 10-045 | |
| 425 | "Oddział Kardiologiczny Publiczny Samodzielny ZOZ Wojewódzkie Centrum Medyczne | Opole | Poland | 45-418 | |
| 426 | Specjalistyczny Zakład Opieki Zdrowotnej Poradnia lekarzy specjalistów "Jantar" | Ostrów Wielkopolski | Poland | 63-400 | |
| 427 | II Oddział Wewnętrzny Samodzielny Publiczny Zakład Opieki Zdrowotnej | Pabianice | Poland | 95-200 | |
| 428 | "Samodzielny Szpital Wojewódzki im. Mikołaja Kopernika, Oddział Kardiologiczny | Piotrków Trybunalski | Poland | 97-300 | |
| 429 | Medyczne Centrum Hetmańska, Indywiualna Specjalistyczna Praktyka Lekarska, Dr n. med. Piotr Leszczyński | Poznań | Poland | 60-218 | |
| 430 | Specjalistyczne Centrum Diagnostyczno-Lecznicze Bamberski Dwór | Poznań | Poland | 60-539 | |
| 431 | Oddział Wewnetrzny I, Szpital Kolejowy im. dr med. Włodzimierza Roeslera | Pruszków | Poland | 05-800 | |
| 432 | Samodzileny Publiczny Zakład Opieki Zdrowotnej w Puławach, Szpital Specjalistyczny | Puławy | Poland | 24-100 | |
| 433 | Wojewódzki Szpital Zespolony, Oddział Kardiologiczny | Płock | Poland | 09-400 | |
| 434 | Specjalistyczna Przychodnia Lekarska "Medikard" | Płock | Poland | 09-402 | |
| 435 | Zakład Hemodynamiki, Wojewódzki Szpital Specjalistyczny | Radom | Poland | 26-617 | |
| 436 | "Oddział Kardiologii z Pododdziałem Ostrych Zespołów Wieńcowych i z Ośrodkiem Implantacji Rozruszników Serca, | Rzeszów | Poland | 35-301 | |
| 437 | Oddział Kardiologii, SP ZZOZ Sandomierz | Sandomierz | Poland | 27-600 | |
| 438 | Oddział Kardiologiczny Wojewódzki Szpital Specjalistyczy w Siedlcach | Siedlce | Poland | 08-110 | |
| 439 | Oddział Kardiologii Samodzielny Publiczny Zakład Opieki Zdrowotnej w Sieradzu im. Kardynała Stefana Wyszyńskiego | Sieradz | Poland | 98-200 | |
| 440 | "Oddział Kardiologii, Wojewódzki Szpital Zespolony w Skierniewicach, " | Skierniewice | Poland | 96-100 | |
| 441 | NZOZ Przychodnia Zadebie, Przychodnia Kardiologiczna | Skierniewice | Poland | 96-100 | |
| 442 | "Oddział Kardiologii Inwazyjnej i Angiologii z Pr. Hemodynamiki | Stalowa Wola | Poland | 37-450 | |
| 443 | Szpital Specjalistyczny Św.Jana, Oddział Kardiologii, | Starogard Gdański | Poland | 83-200 | |
| 444 | Indywidualna Specjalistyczna Praktyka Lekarska | Szczecin | Poland | 71-531 | |
| 445 | Poradnia Kardiologiczna | Tarnów | Poland | 33-100 | |
| 446 | Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny-Cardiology | Tarnów | Poland | 33-100 | |
| 447 | Niepubliczny Zakład Opieki Zdrowotnej "Nasz Lekarz", Praktyka Grupowa Lekarzy Rodzinnych z Przychodnią Specjalistyczną | Torun | Poland | 87 100 | |
| 448 | Oddział Kardiologii Wojewódzki Szpital Zespolony | Toruń | Poland | 87-100 | |
| 449 | Oddział Kardiologiczny Szpital Wolski im. dr Anny Gostyńskiej Samodzielny Publiczny Zakład Opieki Zdrowotnej | Warszawa | Poland | 01 - 211 | |
| 450 | Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej w Warszawie | Warszawa | Poland | 02-097 | |
| 451 | II Klinika Choroby Wieńcowej Instytutu Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego | Warszawa | Poland | 02-637 | |
| 452 | Centrum Leczenia Chorób Cywilizacyjnych | Warszawa | Poland | 02-777 | |
| 453 | Międzyleski Szpital Specjalistyczny w Warszawie | Warszawa | Poland | 04-749 | |
| 454 | NZOZ Starówka | Warszawa | Poland | ||
| 455 | "Oddział Kardiologiczny Wałbrzyski Ośrodek Kardiologii Interwencyjnej Specjalityczny Szpital im. Dr Alfreda Sokołowskiego | Wałbrzych | Poland | 58-309 | |
| 456 | Osrodek Chorob Serca, Klinika Kardiologii 4 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej | Wroclaw | Poland | 50-981 | |
| 457 | Synexus SCM Sp.z o o. | Wrocław | Poland | 50-088 | |
| 458 | Niepubliczny Zakład Opieki Zdrowotnej, Centrum Badań Klinicznych | Wrocław | Poland | 50-349 | |
| 459 | "Śląskie Centrum Chorób Serca, III Katedra i Oddział Kliniczny Kardiologii Śląskiego Uniwersytetu Medycznego | Zabrze | Poland | 41-800 | |
| 460 | Oddział Kardiologiczny Szpital Wojewódzki im. Kardynała Stefana Wyszyńskiego | Łomża | Poland | 18-404 | |
| 461 | Niepubliczny Zakład Opieki Zdrowotnej POLIMEDICA | Łódź | Poland | 90-302 | |
| 462 | All-Med Centrum Medyczne | Łódź | Poland | 94-050 | |
| 463 | Research and Cardiovascular Corp. | Ponce | Puerto Rico | 00717-1322 | |
| 464 | Spitalul Clinic Judetean de Urgenta Bacau | Bacau | Romania | 600114 | |
| 465 | S.C. Duo Medical S.R.L. | Bucharest | Romania | 010584 | |
| 466 | Cardiomed SRL | Bucharest | Romania | 020506 | |
| 467 | Centrul Medical SANA | Bucuresti | Romania | 011025 | |
| 468 | Institutul Inimii "Niculae Stanicioiu" | Cluj-Napoca | Romania | 400001 | |
| 469 | Cardiomed SRL | Craiova | Romania | 200147 | |
| 470 | Dr. C.I. Parhon Hospital | Iasi | Romania | 700503 | |
| 471 | Clinical county Hospital | Sibiu | Romania | 550245 | |
| 472 | Institutul de Boli Cardiovasculare si Transplan Tg. Mures | Targu Mures | Romania | 540136 | |
| 473 | County Hospital | Timisoara | Romania | 300736 | |
| 474 | Novamed s.r.o. | Banská Bystrica | Slovakia | 97405 | |
| 475 | Alian s.r.o. | Bardejov | Slovakia | 085-01 | |
| 476 | 5. Interna klinika LF UK, FNsP Bratislava, Nemocnica Ruzinov | Bratislava | Slovakia | 826 06 | |
| 477 | Cardio D&R spol. s r.o. | Kosice | Slovakia | 040-22 | |
| 478 | Kardiomed s.r.o. | Lučenec | Slovakia | 98401 | |
| 479 | NZZ Kardiocentrum Nitra s.r.o. | Nitra | Slovakia | 950-01 | |
| 480 | MUDr. Tibor DURIS, CSc., s.r.o. | Nove Zamky | Slovakia | 94052 | |
| 481 | Nemocnica s poliklinikou Považská Bystrica | Považská Bystrica | Slovakia | 017 26 | |
| 482 | Fakultna Nemocnica Trencin | Trencin | Slovakia | 911 71 | |
| 483 | Žilpo s.r.o. | Žilina | Slovakia | 010 01 | |
| 484 | Medivasa s.r.o. | Žilina | Slovakia | 010-01 | |
| 485 | "Klinichne obyednannia shvydkoi medychnoi dopomogy, m. Dnipropetrovs'k,Dnipropetrovs'ka derzhavna medychna akademiya, kafedra gospital'noi terapii #2 | Dnipropetrovsk | Ukraine | 49006 | |
| 486 | Oblasnyi klinichnyi kardiologichnyi dyspanser, m. Ivano-Frankivsk, Ivano-Frankivskyi derzhavnyi medychnyi universytet, kafedra terapii # 3 | Ivano-Frankivsk | Ukraine | 76005 | |
| 487 | TOV "Kardiologichna klinika "Sertse i sudyny" m. Kyiv | Kyiv | Ukraine | 1032 | |
| 488 | Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska" AMN Ukrainy, m. Kyiv, viddilenia symptomatychnykh arterial'nykh gipertenziy | Kyiv | Ukraine | 3680 | |
| 489 | Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska", viddil reanimatsii ta intensyvnoi terapii, m. Kyiv | Kyiv | Ukraine | 3680 | |
| 490 | Komunal'na ustanova "Oblasnyi kardiologichnyi dyspanser", viddilenia intensyvnoi terapii, m. Zaporizhzhia | Zaporizhzhya | Ukraine | 69000 | |
| 491 | Kardioarytmologichnyi tsentr Zhytomyrs'koi oblasnoi klinichnoi likarni im. O.F. Gorbachevs'kogo, m. Zhytomyr | Zhytomyr | Ukraine | 10002 |
Sponsors and Collaborators
- Cogentus Pharmaceuticals
Investigators
- Study Director: Pablo Lapuerta, MD, Cogentus Pharmaceuticals
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00557921
Other Study ID Numbers:
- CG104
- EudraCT 2007-005891-15
First Posted:
Nov 14, 2007
Last Update Posted:
Jan 28, 2009
Last Verified:
Jan 1, 2009
Keywords provided by ,
,
Additional relevant MeSH terms: