PROPIU: Customization of Cardiac Readaptation Based on Force-velocity Profile and Heart Rate Variability
Cardiac readaptation aims to mitigate cardiovascular risks and enhance the quality of life among coronary patients. Our research laboratory has an international expertise in training optimization in top-athletes and a previous study has demonstrated the efficacy of optimizing cardiac rehabilitation through the power-force-velocity profile (PFVP). The findings exhibited significant improvements in aerobic capacity, muscular strength, and cardiovascular parameters among patients who were trained based on their PFVP. Guided training utilizing heart rate variability (HRV) is also garnering increasing interest as a means to optimize training load and promote recovery
|Condition or Disease
Our study aims to evaluate the application of HRV in regulating training load based on fatigue levels in cardiac rehabilitation patients utilizing the PFVP framework.
Arms and Interventions
|Experimental: Experimental group
Patient with acute coronary syndrome will be included. According to their initial strength-speed profile, coronary patients will benefit from an individualized cardiac rehabilitation program, with strength or speed training adapted to the autonomic nervous system (ANS).
Other: training strategy with adaptation of training strategies to the ANS
a training strategy for subjects whose PFVP is in favour of strength or speed with training load adjusted according to SNA
|Active Comparator: Control group
Patient with acute coronary syndrome will be included. According to their initial force-velocity profile, coronary patients will have an individualized cardiac rehabilitation program, either with a training in force or in velocity.
Other: training strategy (standard practice)
a training strategy for subjects whose PFVP is in favour of strength or speed
Primary Outcome Measures
- The root mean square of successive differences in heart rate or RMSSD [Baseline to 2 months]
The root mean square of successive differences in heart rate or RMSSD will be measured from a nocturnal Holter ECG recording at the end of 8 weeks of exercise retraining and compared with the initial pre-training value. weeks of exercise re-training and compared with the initial pre-training value.
Secondary Outcome Measures
- Value of maximum oxygen consumption [Baseline to 2 months]
VO2 max (ml/min/kg) thanks to 24-hour ECG recording
- Assessment of the ANS sympathetic branch [Baseline to 2 months]
Assessment of the ANS sympathetic branch thanks to SDNN index value
- Assessment of the ANS parasympathetic branch [Baseline to 2 months]
Assessment of the ANS parasympathetic branch thanks to RMSSSD index value
- non-invasive measurement of arterial stiffness [Baseline to 2 months]
value of pulse wave propagation velocity
- measurement of upper and lower limb muscle strength [Baseline to 2 months]
it's a composite outcome : measurement of handgrip (kg) thanks to Jamar hydraulic hand dynamometer measurement maximum quadriceps strength (kg) thanks to Contrex, Physiomed
- assessment of PFVP evolution [Baseline to 2 months]
assessment of PFVP evolution thaks to cycloergometer sprint (Monark, Vansbro)
- assessment of physical a activity and sedentary behavior [Baseline to 2 months]
it's a composite outcome : assessment of physical a activity and sedentary behavior thanks to actimetry (Actigraph GT9x) assessment of physical a activity and sedentary behavior thanks to Adult Physical Activity Questionnaire (APAQ)
- quality of life assessment [Baseline to 2 months]
it's a composite outcome : with mental quality of life score with physical quality of life score
- assessment of subjective fatigue [Baseline to 2 months]
assessment of subjective fatigue thanks to FACIT-F questionary
- biological data [Baseline to 2 months]
it's a composite outcome : complete blood biology and relevant inflammatory biomarkers involved in cardiac rehabilitation.
Acute Coronary Syndrome treated in the last 6 months
Medical revascularization (angioplasty ± stenting) or surgical (coronary artery bypass)
Initial CPETt: MPA ≥ 60w in women and ≥80w in men
- Significant co-morbidities limited practice of physical activity
Contacts and Locations
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Saint Etienne
- Principal Investigator: David HUPIN, MD, CHU SAINT-ETIENNE
Study Documents (Full-Text)None provided.