Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes
Study Details
Study Description
Brief Summary
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.
Study Design
Outcome Measures
Primary Outcome Measures
- Adherence to the educational programme measured by the frequency of use of the evidence based treatments: Aspirin, Heparin, Clopidogrel, Beta blockers, Statins. []
Secondary Outcome Measures
- Comparison of investigations and tests []
- Use of other treatments []
- Counselling for lifestyle changes []
- Referral to smoking cessation clinics []
- Cardiac rehabilitation []
- Compliance to treatment at 6 months []
- Comparison of clinical events at 6 months []
Eligibility Criteria
Criteria
Inclusion Criteria:All patients admitted to the hospital (either through casualty or directly to the wards), with a good clinical history of an acute coronary syndrome with one or more of the following:
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Ischaemic changes on the admission ECG (including patients with bundle branch block)
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Elevated Troponin or cardiac enzymes on admission
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Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan)
Written informed consent
Exclusion Criteria:
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Patients with persistent ST elevation >1mm in two or more contiguous leads on the ECG.
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Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital Aintree | Aintree | United Kingdom | ||
| 2 | Monklands Hospital | Airdrie | United Kingdom | ||
| 3 | Antrim Hospital | Antrim | United Kingdom | ||
| 4 | Barnet General Hospital | Barnet | United Kingdom | ||
| 5 | Barnsley District General Hospital | BArnsley | United Kingdom | ||
| 6 | Basildon Hospital | Basildon | United Kingdom | ||
| 7 | North Hampshire Hospital | Basingstoke | United Kingdom | ||
| 8 | Mater Infirmorum Hospital | Belfast | United Kingdom | ||
| 9 | Royal Victoria Hospital | Belfast | United Kingdom | ||
| 10 | Birmingham Heartlands Hospital | Birmingham | United Kingdom | ||
| 11 | Bridlington And District Hospital | Bridlington | United Kingdom | ||
| 12 | The Royal Sussex County Hospital | Brighton | United Kingdom | ||
| 13 | Cumberland Infirmary | Carlisle | United Kingdom | ||
| 14 | Leighton Hospital | Crewe | United Kingdom | ||
| 15 | Darent Valley Hospital | Dartford | United Kingdom | ||
| 16 | Eastbourne District General Hospital | Eastbourne | United Kingdom | ||
| 17 | Western Infirmary | Glasgow | United Kingdom | ||
| 18 | Withybush General Hospital | Haverfordwest | United Kingdom | ||
| 19 | Altnagelvin Area Hospital | Londonderry | United Kingdom | ||
| 20 | Luton and Dunstable Hospital | Luton | United Kingdom | ||
| 21 | Macclesfield District General Hospital | Macclesfield | United Kingdom | ||
| 22 | Northampton General Hospital | Northampton | United Kingdom | ||
| 23 | Royal Alexandra Hospital | Paisley | United Kingdom | ||
| 24 | Pontefract General Infirmary | Pontefract | United Kingdom | ||
| 25 | Whiston Hospital | Prescot | United Kingdom | ||
| 26 | Oldchurch Hospital | Romford | United Kingdom | ||
| 27 | Rotherham District General Hospital | Rotherham | United Kingdom | ||
| 28 | Hope Hospital | Salford | United Kingdom | ||
| 29 | University Hospital Of North Tees | Stockton-on-Tees | United Kingdom | ||
| 30 | University Hospital Of North Staffordshire | Stoke-on-Trent | United Kingdom | ||
| 31 | Wordsley Hospital | Stourbridge | United Kingdom | ||
| 32 | Taunton and Somerset Hospital | Taunton | United Kingdom | ||
| 33 | Torbay Hospital | Torquay | United Kingdom | ||
| 34 | Pinderfields General Hospital | Wakefield | United Kingdom | ||
| 35 | West Cumberland Hospital | Whitehaven | United Kingdom | ||
| 36 | Royal Albert Edward Infirmary | Wigan | United Kingdom | ||
| 37 | Wrexham Maelor Hospital | Wrexham | United Kingdom |
Sponsors and Collaborators
- Royal Brompton & Harefield NHS Foundation Trust
- Sanofi
- Bristol-Myers Squibb
Investigators
- Principal Investigator: Marcus Flather, Royal Brompton & Harefield NHS Trust, Imperial College London
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- MREC/03/10/48