Acute Effect of Exercise on Vascular Function
Study Details
Study Description
Brief Summary
The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Slow-paced walking Subjects will complete 47 minutes of walking at slow pace. |
Other: Slow-paced walking
Subjects will complete 47 minutes of walking on a treadmill at a slow-pace.
Device: Treadmill
|
| Moderate-paced walking Subjects will complete 47 minutes of walking at a moderate pace. |
Other: Moderate-paced walking
Subjects will complete 47 minutes of walking on a treadmill at a moderate pace.
Device: Treadmill
|
| Interval training Subjects will complete 40 minutes of walking alternating between a moderate and fast pace. |
Other: Interval Training
Subjects will complete 40 minutes of walking on the treadmill alternating between a moderate and a fast pace.
Device: Treadmill
|
Outcome Measures
Primary Outcome Measures
- Change in vascular endothelial function [Baseline, 15 minutes after exercise and 1 hour after exercise]
Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. Brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.
Secondary Outcome Measures
- Change in arterial stiffness [Baseline, 15 minutes after exercise and 1 hour after exercise]
Arterial stiffness (aortic pulse wave velocity and augmentation index) will be measured using applanation tonometry.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Men and women 18 to 79 years of age
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Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
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Premenopausal women will be eumenorrheic.
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Able to give consent.
Exclusion Criteria:
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History of hepatic disease or infection with hepatitis B, C or HIV
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History of other relevant on-going or recurrent illness
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Recent (within 3 months) or recurrent hospitalizations
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Current intake of medications that may affect study results
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Use of tobacco products
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Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
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Pregnancy (positive urine pregnancy test) or lactation
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Perimenopausal women
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Integrative Cardiovascular Physiology Laboratory | Gainesville | Florida | United States | 32611 |
Sponsors and Collaborators
- University of Florida
Investigators
- Principal Investigator: Demetra Christou, PhD, University of Florida
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB201401078