Acute High Intensity Interval Training and Blood Flow Restriction

Sponsor

Nanyang Technological University (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT05835544

Collaborator

(none)

Enrollment

Location

Arms

Anticipated Duration (Months)

1.5

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The study aims to look at the blood flow restriction (BFR) + high intensity interval training (HIIT) variables to induce an optimal acute training stimulus (i.e., acute responses in main outcome measures of muscular activation, muscular deoxygenation, and secondary outcome measures of heart rate (HR), blood lactate (bLa), subjective ratings of perceived exertion and discomfort)

The hypotheses for this study are: (i) BFR increases muscular deoxygenation, muscular activation when HIIT exercise is of the same intensity, (ii) however, comparing between a lower BFR + HIIT exercise intensity (e.g. 80% V̇O2max) and higher HIIT exercise intensity (e.g. 100% V̇O2max), muscular deoxygenation and activation will be similar but HR will be lower in the BFR + HIIT condition.

Condition or Disease	Intervention/Treatment	Phase
Acute Exercise Responses	Other: Active Comparator: HIIT Control Other: Experimental: HIIT + BFR between cycling sets Other: Experimental: HIIT + BFR moderate occlusion during cycling Other: Experimental: HIIT + BFR high occlusion during cycling	N/A

Detailed Description

This study revolves around the optimisation of blood flow restriction (BFR) and high-intensity interval training (HIIT) protocols for the racket sport athlete. The study aims to look at the BFR + HIIT variables to induce an optimal acute training stimulus. This can be achieved with the consideration of two main research questions: (i) What is the ideal combination of BFR cuff pressure and exercise intensity (i.e. cycling) to elicit favourable training stimuli, i.e., acute responses in main outcome measures of muscular activation, muscular deoxygenation, and secondary outcome measures of heart rate (HR), blood lactate (bLa), subjective ratings of perceived exertion and discomfort?; (ii) How does BFR + HIIT compare with traditional HIIT at a similar or higher exercise intensity in terms of these acute responses?

Study Design

Study Type:

Interventional

Actual Enrollment :

24 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Other

Official Title:

Acute Responses to High-intensity Interval Exercise (HIIE) and Blood Flow Restriction (BFR)

Actual Study Start Date :

Aug 1, 2022

Anticipated Primary Completion Date :

Dec 1, 2023

Anticipated Study Completion Date :

Dec 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: HIIT Control High intensity interval cycling	Other: Active Comparator: HIIT Control Complete 3 sets of five repetitions of 30 seconds cycling at 100% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets.
Experimental: HIIT + BFR between cycling sets High intensity interval cycling with blood flow restriction applied between sets of cycling	Other: Experimental: HIIT + BFR between cycling sets Complete 3 sets of five repetitions of 30 seconds cycling at 100% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied for 2 minutes during the passive rest at 80% of limb occlusion pressure.
Experimental: HIIT + BFR moderate occlusion during cycling High intensity interval cycling with moderate blood flow restriction applied during cycling	Other: Experimental: HIIT + BFR moderate occlusion during cycling Complete 3 sets of five repetitions of 30 seconds cycling at 70% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied during and between exercise repetitions at 50% of limb occlusion pressure and deflated during passive rest periods.
Experimental: HIIT + BFR high occlusion during cycling High intensity interval cycling with high blood flow restriction applied during cycling	Other: Experimental: HIIT + BFR high occlusion during cycling Complete 3 sets of five repetitions of 30 seconds cycling at 70% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied during and between exercise repetitions at 80% of limb occlusion pressure and deflated during passive rest periods.

Outcome Measures

Primary Outcome Measures

Heart rate [Measured and compared between each acute arm (condition)]
Blood lactate concentration [Measured and compared between each acute arm (condition)]
Muscle activation [Measured and compared between each acute arm (condition)]
Surface electromyography of the vastus lateralis and biceps femoris muscles to determine electrical activity of the motor units (physiological parameter)
Muscle oxygenation [Measured and compared between each acute arm (condition)]
Near infra-red spectroscopy to examine regional tissue (the vastus lateralis muscle) oxygenation i.e, the percentage of haemoglobin and deoxyhaemoglobin (physiological parameter)

Secondary Outcome Measures

Rating of perceived exertion [Measured and compared between each acute arm (condition)]
Borg Rating of Perceived Exertion scale 6-20 (6 = no exertion at all; 20 = maximal exertion)
Exertion and Pain scale [Measured and compared between each acute arm (condition)]
Borg Category-Ratio (CR) 10 scale (0 = No exertion at all; 10 = Maximal)

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Male
Age: 18-40 years
Competed in competitive varsity sports (endurance, tennis, badminton, squash, football, basketball, etc.) at the varsity/club level
Actively training for at least 2 sessions (1 - 1.5h) per week
Healthy (free from illnesses) and no musculoskeletal injuries for the past 6 months
No history of cardiometabolic, vascular diseases or similar conditions (high blood pressure, peripheral vascular diseases, heart diseases, metabolic syndrome, diabetes, stroke, etc.).
Pass pre-participation health screening tests - Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and Australian Institute of Sport (AIS) Blood Flow Restriction (BFR) pre-screening questionnaire (no history of any risk factors).
Maximal oxygen uptake (VO2max) of ≥40mmol/min/kg during a maximal aerobic cycling test.
Non-smoker
Drink alcohol less than 3 times each week and less than 3 drinks each time

Exclusion Criteria:

Any diagnosed form of cardiometabolic disease (CVD, diabetes, metabolic syndrome, hypertension)
Any symptoms contraindication of exercise testing (eg chest pains)
Any balance or dizziness problems
Any chronic medical conditions (whether medicated or not)
Any bone joint problems
Any Physician diagnosed contraindications to exercise

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Human Bioenergetics Laboratory, National Institute of Education, Nanyang Technological University	Singapore		Singapore	637616

Sponsors and Collaborators

Nanyang Technological University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Stephen Burns, Associate Professor, Nanyang Technological University

ClinicalTrials.gov Identifier:

NCT05835544

Other Study ID Numbers:

IRB-2022-135

First Posted:

Apr 28, 2023

Last Update Posted:

Apr 28, 2023

Last Verified:

Apr 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Yes

Plan to Share IPD:

Yes

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Stephen Burns, Associate Professor, Nanyang Technological University

High intensity interval training

Blood flow restriction

Study Results

No Results Posted as of Apr 28, 2023