Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure
Study Details
Study Description
Brief Summary
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
Patients presenting via Emergency Room or inpatients who are noted to be in acute hypercapnic respiratory failure will be approached for consent and if they are agreeable will be randomized to the standard of care arm which would be the use of Bilevel Positive pressure ventilation via face mask vs the intervention arm which would use the Biphasic Cuirass Ventilation.
Patients will be monitored and treated in the Medical ICU and will be regularly clinically assessed as per usual standard of care. The study investigators will obtain periodic Arterial/Venous Blood gas sampling to assess for improvement or lack thereof in patients Carbon dioxide levels.
If patients' condition doesn't improve or deteriorates their primary treating physician will have full authority to withdraw such patients from study and or change the modality of the patient's treatment.
This is a pilot study, and the investigators are aiming to compare the success rate of Biphasic cuirass ventilation when compared to non-invasive positive pressure ventilation.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
No Intervention: Conventional Arm Patients will be placed on Non invasive positive pressure ventilation per current standard of care. |
|
Active Comparator: Intervention Arm Patient in this arm will be placed on Biphasic Cuirass Ventilation |
Device: Intervention Arm (Biphasic cuirass ventilation)
Patients in this arm will be placed on Biphasic cuirass ventilation
|
Outcome Measures
Primary Outcome Measures
- Resolution of Hypercapnic Respiratory Failure [1-3 days]
Resolution of Hypercapnic Respiratory failure will be assessed and compared with the current standard of care which is non invasive positive pressure ventilation using Arterial or Venous Blood Gas analysis.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
admission diagnosis of hypercapnic respiratory failure
-
pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample.
Exclusion Criteria:
-
age <21
-
Pregnant
-
Inmate/Prisoner
-
Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery)
-
Chest wall defect, neuromuscular disease or diaphragmatic paralysis.
-
BMI >50
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Missouri Hospitals | Columbia | Missouri | United States | 65212 |
Sponsors and Collaborators
- University of Missouri-Columbia
- Hayek Medical
Investigators
- Principal Investigator: Dennis Chairman, MD, University of Missouri-Columbia
Study Documents (Full-Text)
None provided.More Information
Publications
- 2094467