Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
Study Details
Study Description
Brief Summary
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
The main question it aims to answer:
To compare between patients complicated with acute kidney injury and exposure of renal replacement therapy (AKI-RRT) and patients complicated with acute kidney injury which does not require renal replacement therapy, in associated with in-hospital postoperative mortality.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Type of study: observational study
Participant population: Post cardiac surgery patients with condition of acute kidney injury postoperative, will be assigned into 2 groups, based on their exposure to renal replacement therapy. Those groups are:
Group AKI-RRT : patients with AKI postoperative with exposure of renal replacement therapy Group AKI non RRT : patients with AKI postoperative, with no exposure to renal replacement therapy Researchers will compare group AKI-RRT and AKI non RRT to analyse the association to postoperative mortality, and other factors that related to mortality variable.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| AKI-RRT Post cardiovascular surgery patients with condition of acute kidney injury postoperative; and with an exposure of renal replacement therapy (intermittent haemodialysis or continuous renal replacement therapy) which is indicated postoperatively. |
Procedure: Renal Replacement Therapy (RRT)
Renal Support therapy which consist of procedure of intermittent hemodialysis (IHD) or continuous veno-venous hemofiltration/hemodialysis/hemodiafiltration (CVVH/CVVHD/CVVHDF)
|
| AKI non RRT Post cardiovascular surgery patients with condition of acute kidney injury postoperative; but without exposure of renal replacement therapy. |
Outcome Measures
Primary Outcome Measures
- Mortality [From ICU admission postoperative until the death date during hospital care, assessed up to 3 months]
Number of participants who died of any cause during postoperative care in hospital
Secondary Outcome Measures
- ICU stay over 5 days [Time of ICU length of stay measured with days, up to 4 weeks]
Number of participants which the postoperative ICU length of stay more than 5 days
- Mechanical Ventilation > 48 hours [Time of ventilator usage measure with hours, up to 4 weeks]
Number of participants which the postoperative usage of mechanical ventilation (breathing ventilator) more than 48 hours
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients who are at least 18 years old, underwent cardiac surgery in Harapan Kita National Cardiovascular Center from January 2020 to December 2022.
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Patients with condition was complicated with Acute Kidney Injury (AKI) which was characterised by an increase in serum creatinine > 0.3 mg/dL or > 150% of the preoperative serum creatinine value, which was checked within 12 hours post-operative.
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All patients' data is recorded in the medical records unit.
Exclusion Criteria:
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Patients with previous history of dialysis or renal failure in dialysis.
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Incomplete or loss of patients' data.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Cardiovascular Center | Jakarta | DKI Jakarta | Indonesia | 11420 |
Sponsors and Collaborators
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Investigators
- Study Chair: Bambang Widyantoro, PhD, Institutional Review Board
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 01.202308.101