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Acute Kidney Injury in Poly Trauma Patients

Sponsor
Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT06108765
Collaborator
(none)
100
Enrollment
13
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The aim of this study is to identify the incidence and the factors associated with acute kidney injury in adult poly trauma patients

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Trauma causes significant morbidity and mortality in all age groups but particularly for those below 60 years and is one of the top 5 causes of death (1,2).Most deaths occur in adults who are between 15 and 44 years(3).Polytrauma originates from the Greek words poly which means multiple and trauma which means wounds. The term polytrauma, which was defined using the new Berlin definition, as cases with an Abbreviated Injury Scale (AIS)≥3 for two or more different body regions and one or more additional variables from five physiologic parameters (hypotension[systolic blood pressure≤90 mmHg], unconsciousness[Glasgow Coma Scale score≤8], acidosis [base excess≤ -6.0], coagulopathy [partial thromboplastin time≥40 s or international normalized ratio≥1.4], and age [≥70 years]) [4].There are complex pathophysiological changes that happen in a polyrauma patient which requires effective treatment for improving morbidity and mortality outcomes. Hemorrhage, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are some of the complications of trauma whose effects are not only local but also systemic. There are mechanisms and triggers which result in cardio-vascular shock, hemostasis, apoptosis, organ dysfunctions and immune suppression (CHAOS) [5]. These local and systemic pathophysiological changes that occur in polytrauma (CHAOS) eventually lead to Acute Kidney Injury (AKI) which further worsens their outcomes [6,7].

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Other
    Time Perspective:
    Prospective
    Official Title:
    Acute Kidney Injury in Poly Trauma Patients
    Anticipated Study Start Date :
    Nov 1, 2023
    Anticipated Primary Completion Date :
    Nov 1, 2024
    Anticipated Study Completion Date :
    Dec 1, 2024

    Outcome Measures

    Primary Outcome Measures

    1. Determine the incidence of acute kidney injury in poly trauma patients [7 days]

      To identify the incidence and factors associated with acute kidney injury in adult polytrauma patients

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    16 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • The present study will be conducted on patients with multiple trauma of both genders "without intently selected certain gender" who have no previous history of kidney disease or chronic illness.
    Exclusion Criteria:

    • • Patients who are less than 16 years old.

    • Patients with preexisting kidney disease or localized individual trauma.

    • patients with diabetes and hypertension.

    • Patients Post cardiac arrest

    • patients leaving the hospital on the same day or transferred to a different hospital will be excluded from this study.

    • patients refusing study will be excluded.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Assiut University

    Investigators

    • Study Director: Omar Ibrahim, Assiut University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Omar ibrahim abd elsalam, Emergency medicine residency, Assiut University
    ClinicalTrials.gov Identifier:
    NCT06108765
    Other Study ID Numbers:
    • Acute kidney injury in trauma
    First Posted:
    Oct 31, 2023
    Last Update Posted:
    Oct 31, 2023
    Last Verified:
    Oct 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Omar ibrahim abd elsalam, Emergency medicine residency, Assiut University
    Polytrauma
    Additional relevant MeSH terms:
    Acute Kidney Injury
    Wounds and Injuries
    Multiple Trauma

    Study Results

    No Results Posted as of Oct 31, 2023