Acute Liver Injury in Patients With Pneumonia
Study Details
Study Description
Brief Summary
Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.
A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .
Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.
In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.
There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group A About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact |
Other: Acute Liver Injury
To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.
|
| Group B About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay |
Other: Acute Liver Injury
To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.
|
Outcome Measures
Primary Outcome Measures
- Impact of Acute liver injury due to Pneumonia [From Hospital admission date to Two Months]
Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital).
Secondary Outcome Measures
- Patients with Pneumonia only [From Hospital admission date to Two Months]
To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with pneumonia that developed Acute Liver Injury
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Covid 19 pneumonia
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Patients With acute liver injury only.
Exclusion Criteria:
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Cancer
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Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications.
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Patients who younger than 18 yrs old
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pregnancy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Faculty Of Medicine | Assuit | Egypt |
Sponsors and Collaborators
- Assiut University
Investigators
- Study Chair: Zain Elabdeen Ahmed, Professor, Assuit Faculty of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Acute Liver Injury