Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia
Study Details
Study Description
Brief Summary
This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVE:
- To compare the overall survival (OS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in patients with BCR-ABL-negative B cell precursor acute lymphoblastic leukemia (ALL) who are minimal residual disease (MRD) negative after induction and intensification chemotherapy, based on multiparameter flow cytometric (MFC) assessment of residual blasts.
SECONDARY OBJECTIVES:
-
To compare the relapse-free survival (RFS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in MRD negative patients after induction and intensification chemotherapy.
-
To compare the OS and RFS of those patients who are MRD positive (+) at step 3 randomization/registration and then convert to MRD negative (-) after 2 cycles of blinatumomab or consolidation chemotherapy.
-
To assess the toxicities of blinatumomab in this patient population. IV. To assess the toxicities of the modified E2993 chemotherapy regimen in this patient population.
-
To describe the outcome of patients who proceed to allogeneic blood or marrow transplant after treatment with or without blinatumomab.
LABORATORY OBJECTIVES:
-
To determine differences in MRD kinetics among patients with the BCR/ABL1-like B-lineage ALL, and to compare the OS (and RFS) of patients with BCR-ABL-like phenotype with those without BCR-ABL-like phenotype.
-
To evaluate the incidence of anti-blinatumomab antibody formation.
OUTLINE:
INDUCTION CHEMOTHERAPY: Patients receive cytarabine intrathecally (IT) on day 1; daunorubicin hydrochloride intravenously (IV) over 10-15 minutes on days 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone orally (PO) daily on days 1-7 (and 15-21 for patients age < 55 years only); methotrexate IT on day 14; pegaspargase intramuscularly (IM) or IV on day 18 (patients age < 55 years); and CD20 positive patients may optionally receive rituximab IV on day 8 and 15. Beginning on day 29, patients with absolute neutrophil count (ANC) >= 0.75 x 109/L and platelets > 75 x 109/L (patients with delayed hematologic recovery) (patients with residual disease that is delaying count begin treatment immediately) receive cyclophosphamide IV over 30 minutes on days 1 and 29, cytarabine IV over 30 minutes or subcutaneously (SC) on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14, 29-42, pegaspargase IM or IV on day 15 (patients age < 55 years), patients receiving treatment for central nervous system (CNS) 2 or 3 leukemia in cycle 1 receive methotrexate IT on days 1, 8, 15, and 22, and CD20 positive patients may optionally receive rituximab IV on days 8 and 15.
INTENSIFICATION THERAPY: Beginning 4 weeks after the completion of cycle 2 of induction therapy, patients receive intensification therapy comprising high-dose methotrexate IV over 2 hours on days 1 and 8, and pegaspargase IM or IV on day 9.
Patients are then randomized to 1 of 2 treatment arms.
Patients randomized to the blinatumomab group receive blinatumomab IV continuously on days 1-28. Treatment repeats every 6 weeks for 2 cycles in the absence of disease progression or unacceptable toxicity. Patients may then undergo allogeneic stem cell transplant (SCT) or proceed to consolidation therapy per investigator discretion.
CONSOLIDATION THERAPY: Beginning after the second cycle of blinatumomab (patients randomized to the blinatumomab group) or after intensification therapy (patients not randomized to blinatumomab), patients receive cytarabine IV over 30 minutes or SC on days 1-5, etoposide IV over 1 hour on days 1-5, methotrexate IT on day 1, and pegaspargase IM or IV on day 5, and CD20 positive patients may optionally receive rituximab IV on day 5. Beginning 4 weeks from day 1 of cycle 1, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may receive rituximab as in cycle 1. Beginning 4 weeks from day 1 of cycle 2, patients receive daunorubicin hydrochloride IV over 10-15 minutes on day 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone PO daily on days 1-7 (and 15-21 for patients age < 55 years); methotrexate IT on day 2; cyclophosphamide IV over 30 minutes on day 29; cytarabine IV over 30 minutes or SC on days 30-33 and 37-40; mercaptopurine PO on days 29-42 and CD20 positive patients may receive rituximab on day 8. Beginning 8 weeks from day 1 of cycle 3, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may optionally receive rituximab as in cycle 1. Patients randomized to blinatumomab repeat cycle 4 and then receive blinatumomab IV continuously on days 1-28.
MAINTENANCE THERAPY: Within 6 weeks after beginning last cycle of consolidation therapy, patients receive mercaptopurine PO daily, methotrexate PO or IV over 2 hours once weekly for 2.5 years, vincristine sulfate IV on day 1 every 3 months, prednisone PO on days 1-5 every 3 months, and methotrexate IT on day 1 every 3 months. Treatment continues for up to 2.5 years in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 5 years.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (blinatumomab, chemotherapy) See Detailed Description |
Procedure: Allogeneic Hematopoietic Stem Cell Transplantation
Undergo allogeneic hematopoietic SCT
Other Names:
Biological: Blinatumomab
Given IV
Other Names:
Drug: Cyclophosphamide
Given IV
Other Names:
Drug: Cytarabine
Given IT, IV, or SC
Other Names:
Drug: Daunorubicin
Given IV
Other Names:
Drug: Daunorubicin Hydrochloride
Given IV
Other Names:
Drug: Dexamethasone
Given PO
Other Names:
Drug: Etoposide
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Mercaptopurine
Given PO
Other Names:
Drug: Methotrexate
Given PO, IT or IV
Other Names:
Drug: Pegaspargase
Given IM or IV
Other Names:
Drug: Prednisone
Given PO
Other Names:
Biological: Rituximab
Given IV
Other Names:
Drug: Vincristine
Given IV
Other Names:
Drug: Vincristine Sulfate
Given IV
Other Names:
|
| Active Comparator: Arm II (chemotherapy) See Detailed Description |
Procedure: Allogeneic Hematopoietic Stem Cell Transplantation
Undergo allogeneic hematopoietic SCT
Other Names:
Drug: Cyclophosphamide
Given IV
Other Names:
Drug: Cytarabine
Given IT, IV, or SC
Other Names:
Drug: Daunorubicin
Given IV
Other Names:
Drug: Daunorubicin Hydrochloride
Given IV
Other Names:
Drug: Dexamethasone
Given PO
Other Names:
Drug: Etoposide
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Mercaptopurine
Given PO
Other Names:
Drug: Methotrexate
Given PO, IT or IV
Other Names:
Drug: Pegaspargase
Given IM or IV
Other Names:
Drug: Prednisone
Given PO
Other Names:
Biological: Rituximab
Given IV
Other Names:
Drug: Vincristine
Given IV
Other Names:
Drug: Vincristine Sulfate
Given IV
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Overall survival [Time between randomization and death from any cause, assessed up to 10 years]
Medians and confidence intervals will be calculated using the Kaplan-Meier method. Comparison of overall survival between treatment arms will be conducted using the one-sided stratified log-rank test with minimal residual disease status, age, CD20 status, rituximab use, and whether patients intend to receive hematopoietic stem cell transplantation or not as stratification factors. A Cox proportional hazards model will be used to assess the effect of treatment and will include receipt of transplant as a time-varying covariate.
Secondary Outcome Measures
- Relapse-free survival [Time from randomization to relapse or death without documentation of relapse, assessed up to 10 years]
Estimates of relapse-free survival, including medians and confidence intervals, will be calculated using the Kaplan-Meier method. Comparison of relapse-free survival between treatment arms will be conducted using the one-sided stratified log-rank test with minimal residual disease status, age, CD20 status, rituximab use, and whether patients intend to receive hematopoietic stem cell transplantation or not as stratification factors. Stratified on those factors, Cox proportional hazards models, will also be used to assess the treatment effect by adjusting other possible clinical and biological risk factors, including cytogenetic abnormalities and the receipt of transplant (included as a time-varying covariate).
- Minimal residual disease (MRD) status [Up to 32 weeks]
Patients who are MRD positive at step 3 randomization/ registration and then convert to MRD negative (-) after 2 cycles of blinatumomab will be compared to those patients who are MRD- at randomization and remain MRD- after 2 cycles of blinatumomab or consolidation chemotherapy. The study will have 80% power to detect 56% reduction in hazard rate in the MRD- remain as MRD- patients (after blinatumomab/consolidation chemotherapy), using one-sided log rank test at the significance level of 0.025 and assuming 2 years of follow-up
- Incidence of adverse events [Up to 10 years]
Will be assessed per the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Classified as either possibly, probably, or definitely related to study treatment. The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns. In addition, we will review all adverse event data that is graded as 3, 4, or 5 and classified as either "unrelated or unlikely to be related" to study treatment in the event of an actual relationship developing.
Other Outcome Measures
- Identification and characterization of the BCR/ABL1-like phenotype [Up to 2 years]
Cox regression analysis will be used to assess whether BCR-ABL-like phenotype is an independent predictor for overall survival (and relapse-free survival), adjusted by treatment effect, minimal residual disease status, age, cytogenetic abnormalities, CD20 status, rituximab use, and whether patients intend to receive hematopoietic stem cell transplantation or not. If a strong interaction effect is detected, Cox regression analysis will be used to look at the treatment difference separately within each of the BCR-ABL-like phenotype categories (negative/positive) to see if the magnitude and direction of the treatment effect differs by phenotype.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
PRE-REGISTRATION
-
Diagnostic bone marrow and peripheral blood specimens must be submitted for immunophenotyping and selected molecular testing, and the establishment of BCR/ABL status; testing will be performed by the Eastern Cooperative Oncology Group (ECOG)-American College of Radiation Imaging Network (ACRIN) Leukemia Translational Research Laboratory (LTRL) and reported to the institution
-
NOTE: IT IS ESSENTIAL THAT A SAMPLE CONTAINING SUFFICIENT BLAST CELLS BE SUBMITTED TO THE ECOG-ACRIN LTRL AT BASELINE SO THAT SUBSEQUENT BONE MARROW ASSESSMENTS OF MRD CAN BE DONE; IN ADDITION TO ALLOWING THE LTRL TO CONFIRM ELIGIBILITY BASED ON BLAST CELL IMMUNOPHENOTYPE AND BCR/ABL STATUS, IT IS ALSO IMPERATIVE THAT AN ADEQUATE NUMBER OF BLASTS BE BANKED FOR ANALYSIS BY DRS MULLIGHAN/WILLMAN. WITHOUT ADEQUATE BASELINE SAMPLES, PATIENTS WILL NOT BE ABLE TO BE TREATED AND RANDOMIZED ON THIS PROTOCOL; IF A BONE MARROW ASPIRATE IS NOT AVAILABLE FOR LTRL SUBMISSION AT BASELINE, IT IS IMPERATIVE THAT DR PAIETTA FROM THE LTRL IS CALLED TO DISCUSS THE PERIPHERAL BLOOD WBC AND BLAST COUNT BEFORE BLOOD ONLY IS SUBMITTED
-
NOTE: Hydroxyurea can be given for up to 5 days prior to initiation of protocol therapy for control of leukocyte count and/or other symptoms or signs; corticosteroids can be given after pre-registration to the protocol and submission of baseline marrow and blood samples for control of leukocyte count and/or other symptoms or signs prior to initiation of protocol therapy if needed; if corticosteroids are given prior to pre-registration, contact the study chair as the patient may still be eligible to participate
-
INDUCTION ELIGIBILITY CRITERIA-STEP 1
-
New diagnosis of B lineage ALL must be made upon bone marrow or peripheral blood immunophenotyping; cases with myeloid antigen expression, but unequivocal lymphoid immunophenotype, are eligible
-
Negativity for the Philadelphia chromosome must be established by conventional cytogenetics, fluorescence in situ hybridization (FISH) and/or polymerase chain reaction (PCR); patients who are negative for the Philadelphia chromosome by conventional cytogenetics must have FISH or PCR performed for BCR/ABL to exclude occult translocations
-
Cytogenetic analysis must be performed from diagnostic bone marrow (preferred) or if adequate number of circulating blasts from peripheral blood; FISH testing for common B-lineage ALL abnormalities including t(9;22) (BCR/ABL1), t(12;21) (ETS-variant gene 6 [ETV6]/runt-related transcription factor 1 [RUNX1]), t(1;19) (pre-B-cell leukemia homeobox 1 [PBX1]/transcription factor 3 [TCF3]), +4,+10,+17, (centromeric [Cen]4/Cen10/Cen17), t(11q23;var), (myeloid/lymphoid or mixed lineage leukemia [MLL]), deletion (del)(9p) (cyclin-dependent kinase inhibitor 2A [CDKN2A]/Cen9), and t(14;var) (immunoglobulin heavy chain [IGH] is encouraged); if there are few or no circulating blasts and an adequate marrow sample cannot be obtained for cytogenetic analysis, the patient may still enroll on the trial
-
Serum direct bilirubin < 2 mg/dl or serum total bilirubin =< 3 (obtained =< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
-
Serum creatinine < 2 mg/dl (obtained =< 48 hours prior to registration); NOTE: the above stipulation for normal hepatic function does not apply if liver dysfunction is due to leukemia infiltration
-
Patient should be human leukocyte antigen (HLA) typed (A, B, C, DR and DQ) during induction therapy phase or a written explanation for not undergoing HLA typing on the flow sheet
-
Patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria:
-
No history of acquired immune deficiency syndrome (AIDS)-related complications other than a history of low CD4+ T-cell count (< 200/mm^3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low
-
Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia
-
Patient must have serum HIV viral load of < 200 copies/mm^3
-
Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy
-
Patient must not be receiving protease inhibitors or once daily formulations containing cobicistat, stavudine, or on regimens containing stavudine or zidovudine
-
It is recommended to utilize a regimen of the integrase inhibitor, dolutegravir, combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine
-
Patient must not have an antecedent hematologic disorder
-
Patient must have no history of recent myocardial infarction (within three months), uncontrolled congestive heart failure, or uncontrolled cardiac arrhythmia
-
Patient must not have a history or presence of clinically relevant central nervous system (CNS) pathology such as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia; Parkinson's disease, cerebellar disease, organic brain syndrome, psychosis, or other significant CNS abnormalities
-
Patient must have a normal cardiac ejection fraction by pretreatment multigated acquisition scan (MUGA) or echocardiogram within 4 weeks prior to registration (resting ejection fraction >= 40% or >= 5% increase with exercise), shortening fraction by echocardiogram >= 24%, or to within the normal range of values for the institution
-
Patient must not have an active uncontrolled infection
-
Women must not be pregnant or breast-feeding and must not become pregnant or breastfeed during protocol therapy and for at least 3 months after protocol therapy; woman of childbearing potential must abstain from sexual activity or be willing to use 2 highly effective forms of contraception throughout protocol therapy and for at least an additional 3 months after the last dose of protocol-specified therapy; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: has not undergone a hysterectomy or bilateral oophorectomy; or has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
Men who have a female partner of childbearing potential must be willing to use 2 highly effective forms of contraception throughout protocol therapy and for at least an additional 3 months after the last dose of protocol-specified therapy; men who have a pregnant partner must be willing to use a condom during sexual activity throughout protocol therapy and for 3 months after the last dose of protocol-specified therapy
-
ECOG performance score 0-3
-
Patient must have given written informed consent
-
POST-INDUCTION THERAPY ELIGIBILITY CRITERIA (PRIOR TO INTENSIFICATION-STEP 2)
-
ECOG performance status 0-2
-
Patients must have achieved a CR or CRi
-
Patients who have achieved a CR or CRi must have maintained peripheral blood evidence of a CR or CRi
-
Patient must be CNS (cerebrospinal fluid [CSF]) negative for leukemia
-
Patients must have resolved any serious infectious complications related to induction
-
Any significant medical complications related to induction must have resolved
-
Serum creatinine =< 2.0 mg/dl (obtained =< 48 hours prior to registration)
-
Serum direct bilirubin < 2 mg/dL or serum total bilirubin =< 3 (obtained =< 48 hours prior to registration)
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN) (obtained =< 48 hours prior to registration)
-
RANDOMIZATION OR ASSIGNMENT TO BLINATUMOMAB OR NO BLINATUMOMAB-STEP 3
-
Patients must have an ECOG performance status of 0-2
-
Patients must have maintained peripheral blood evidence of a remission and must have a CR or CRi, confirmed on restaging bone marrow (BM) aspirate and biopsy
-
Patients must have resolved any serious infectious complications related to therapy
-
Any significant medical complications related to therapy must have resolved
-
Direct or total bilirubin < 1.5 x ULN (unless related to Gilbert's or Meulengracht's syndrome); the values must be obtained within 48 hours prior to randomization
-
Serum creatinine < 1.5 x ULN; the values must be obtained within 48 hours prior to randomization
-
Bone marrow aspirates must be submitted for centralized minimal residual disease (MRD) assessment performed by the ECOG-ACRIN Leukemia Translational Research Laboratory
-
MRD results will be reported to the submitting institution
-
NOTE: FOR MRD ASSESSMENTS, AN ASPIRATE FROM A SEPARATE BONE MARROW ASPIRATION SITE MUST BE SUBMITTED (THE NEEDLE CAN BE RE-DIRECTED THROUGH THE SAME SKIN PUNCTURE SITE); ONLY SUBMIT ASPIRATES FROM THE FIRST PULL OF AN ASPIRATION SITE FOR MRD TESTING; DO NOT SUBMIT SAMPLES FROM THE SECOND OR THIRD PULL OF THE SAME ASPIRATION SITE
-
In B-lineage ALL, MRD levels in peripheral blood or from a dilute marrow aspiration can be 300% lower, on average, than those in bone marrow at a given time point; submitting a first pull from a separate aspiration site will ensure that MRD determinations used in randomization and trial interpretation are accurate
-
NOTE: failure to submit bone marrow aspirates will result in a major violation at the time of an audit
-
CRITERIA FOR ALLOGENEIC TRANSPLANTATION
-
A suitable donor must be identified; there are no restrictions on donor type and can include a matched sibling, a matched or mismatched unrelated donor, a family haplotype matched donor or a cord blood donor (single or double)
-
Patients should meet the eligibility criteria for RANDOMIZATION OR ASSIGNMENT TO BLINATUMOMAB OR NO BLINATUMOMAB-STEP 3
-
Patients must be considered reliable enough to comply with the medication regimen and follow-up, and have social support necessary to allow this compliance
-
CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have an ECOG performance status of 0-3
-
CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have maintained peripheral blood evidence of a remission and must have a CR or CRi, confirmed on restaging BM aspirate and biopsy
-
CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Patients must have resolved any serious infectious complications related to therapy
-
CRITERIA FOR MAINTENANCE THERAPY-STEP 4: Any significant medical complications related to therapy must have resolved
Exclusion Criteria:
-
Mature B ALL (Burkitt's-like leukemia) is excluded from enrollment in this trial; pre-study bone marrow biopsy and aspirate must be completed =< 1 week prior to registration
-
Patient must not have a concurrent active malignancy for which they are receiving treatment
-
Patient must not have intercurrent organ damage or medical problems that will jeopardize the outcome of therapy (i.e., psychiatric disorder, drug abuse, pregnancy)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 4 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 6 | Alaska Regional Hospital | Anchorage | Alaska | United States | 99508 |
| 7 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 8 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 9 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 10 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 11 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 12 | Kingman Regional Medical Center | Kingman | Arizona | United States | 86401 |
| 13 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 14 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 15 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 16 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 17 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 18 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 19 | Community Cancer Institute | Clovis | California | United States | 93611 |
| 20 | University Oncology Associates | Clovis | California | United States | 93611 |
| 21 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 22 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 23 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
| 24 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 25 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 26 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 27 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 28 | Cancer Center of Colorado at Sloan's Lake | Denver | Colorado | United States | 80204 |
| 29 | National Jewish Health-Main Campus | Denver | Colorado | United States | 80206 |
| 30 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 31 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 32 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 33 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 34 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 35 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 36 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 37 | Western Surgical Care | Denver | Colorado | United States | 80220 |
| 38 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 39 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 40 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 41 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 42 | Grand Valley Oncology | Grand Junction | Colorado | United States | 81505 |
| 43 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 44 | Good Samaritan Medical Center | Lafayette | Colorado | United States | 80026 |
| 45 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 46 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 47 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 48 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 49 | National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | United States | 80260 |
| 50 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 51 | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | United States | 06105 |
| 52 | Yale University | New Haven | Connecticut | United States | 06520 |
| 53 | Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | United States | 06790 |
| 54 | Sibley Memorial Hospital | Washington | District of Columbia | United States | 20016 |
| 55 | UM Sylvester Comprehensive Cancer Center at Coral Springs | Coral Springs | Florida | United States | 33065 |
| 56 | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | United States | 33442 |
| 57 | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida | United States | 33021 |
| 58 | Baptist MD Anderson Cancer Center | Jacksonville | Florida | United States | 32207 |
| 59 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 60 | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | United States | 33176 |
| 61 | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | United States | 33324 |
| 62 | Cleveland Clinic-Weston | Weston | Florida | United States | 33331 |
| 63 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 64 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 65 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 66 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 67 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 68 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 69 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 70 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 71 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 72 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 73 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 74 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 75 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 76 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 77 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 78 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 79 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 80 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 81 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 82 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 83 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 84 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 85 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 86 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 87 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 88 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 89 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 90 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 91 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 92 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 93 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 94 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 95 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 96 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 97 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 98 | Hematology Oncology Associates of Illinois-Highland Park | Highland Park | Illinois | United States | 60035 |
| 99 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 100 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 101 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 102 | AMG Libertyville - Oncology | Libertyville | Illinois | United States | 60048 |
| 103 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 104 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 105 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 106 | Illinois Cancer Specialists-Niles | Niles | Illinois | United States | 60714 |
| 107 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 108 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 109 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
| 110 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 111 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 112 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 113 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 114 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 115 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 116 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 117 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 118 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 119 | Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | United States | 60076 |
| 120 | North Shore Medical Center | Skokie | Illinois | United States | 60076 |
| 121 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
| 122 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 123 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 124 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 125 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 126 | Parkview Hospital Randallia | Fort Wayne | Indiana | United States | 46805 |
| 127 | Parkview Regional Medical Center | Fort Wayne | Indiana | United States | 46845 |
| 128 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 129 | Franciscan Health Mooresville | Mooresville | Indiana | United States | 46158 |
| 130 | Reid Health | Richmond | Indiana | United States | 47374 |
| 131 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 132 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 133 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 134 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 135 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 136 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 137 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 138 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 139 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 140 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 141 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 142 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 143 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 144 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 145 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 146 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 147 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 148 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 149 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 150 | Cancer Center of Kansas-Manhattan | Manhattan | Kansas | United States | 66502 |
| 151 | Cancer Center of Kansas - McPherson | McPherson | Kansas | United States | 67460 |
| 152 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 153 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 154 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 155 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 156 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 157 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 158 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 159 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 160 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 161 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 162 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 163 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 164 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 165 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
| 166 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 167 | Oncology Hematology Care Inc-Crestview | Crestview Hills | Kentucky | United States | 41017 |
| 168 | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 169 | Ochsner Health Center-Summa | Baton Rouge | Louisiana | United States | 70809 |
| 170 | Medical Center of Baton Rouge | Baton Rouge | Louisiana | United States | 70816 |
| 171 | Ochsner High Grove | Baton Rouge | Louisiana | United States | 70836 |
| 172 | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | United States | 71202 |
| 173 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 174 | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States | 71103 |
| 175 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 176 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
| 177 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 178 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 179 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 180 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 181 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 182 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 183 | Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 184 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 185 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 186 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 187 | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States | 48183 |
| 188 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 189 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 190 | Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States | 48126 |
| 191 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 192 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 193 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 194 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 195 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 196 | Beaumont Hospital - Farmington Hills | Farmington Hills | Michigan | United States | 48336 |
| 197 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 198 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 199 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 200 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 201 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 202 | William Beaumont Hospital-Grosse Pointe | Grosse Pointe | Michigan | United States | 48230 |
| 203 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 204 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 205 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 206 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 207 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 208 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 209 | Mercy Memorial Hospital | Monroe | Michigan | United States | 48162 |
| 210 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 211 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 212 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 213 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 214 | Henry Ford Medical Center-Columbus | Novi | Michigan | United States | 48377 |
| 215 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 216 | Huron Medical Center PC | Port Huron | Michigan | United States | 48060 |
| 217 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 218 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 219 | Michigan Cancer Specialists | Roseville | Michigan | United States | 48066 |
| 220 | Oakland Colon Rectal Associates | Royal Oak | Michigan | United States | 48067 |
| 221 | Cancer Care Associates PC | Royal Oak | Michigan | United States | 48073 |
| 222 | Comprehensive Medical Center PLLC | Royal Oak | Michigan | United States | 48073 |
| 223 | Hematology Oncology Consultants PC | Royal Oak | Michigan | United States | 48073 |
| 224 | Oakland Medical Group | Royal Oak | Michigan | United States | 48073 |
| 225 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 226 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 227 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 228 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 229 | Premier Hematology Oncology Care | Sterling Heights | Michigan | United States | 48312 |
| 230 | Mitchell Folbe MD PC | Sterling Heights | Michigan | United States | 48314 |
| 231 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 232 | Michigan Institute of Urology-Town Center | Troy | Michigan | United States | 48084 |
| 233 | Claudia BR Herke MD PC | Troy | Michigan | United States | 48085 |
| 234 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 235 | Hematology Oncology Consultants PC-Troy | Troy | Michigan | United States | 48098 |
| 236 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 237 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 238 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 239 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 240 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 241 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 242 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 243 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
| 244 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 245 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 246 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 247 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 248 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 249 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 250 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 251 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 252 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 253 | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | United States | 64118 |
| 254 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 255 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 256 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 257 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 258 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 259 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 260 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 261 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 262 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 263 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 264 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 265 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 266 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 267 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 268 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 269 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 270 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 271 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 272 | Mercy Hospital Washington | Washington | Missouri | United States | 63090 |
| 273 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 274 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 275 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 276 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 277 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 278 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 279 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 280 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 281 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 282 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 283 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 284 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 285 | Nebraska Medicine-Bellevue | Bellevue | Nebraska | United States | 68123 |
| 286 | Nebraska Medicine-Village Pointe | Omaha | Nebraska | United States | 68118 |
| 287 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 288 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 289 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 290 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 291 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 292 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 293 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 294 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 295 | GenesisCare USA - Henderson | Henderson | Nevada | United States | 89074 |
| 296 | Las Vegas Urology - Green Valley | Henderson | Nevada | United States | 89074 |
| 297 | Las Vegas Urology - Pebble | Henderson | Nevada | United States | 89074 |
| 298 | Urology Specialists of Nevada - Green Valley | Henderson | Nevada | United States | 89074 |
| 299 | Las Vegas Urology - Pecos | Las Vegas | Nevada | United States | 89074 |
| 300 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 301 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 302 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 303 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 304 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
| 305 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 306 | Urology Specialists of Nevada - Central | Las Vegas | Nevada | United States | 89106 |
| 307 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 308 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 309 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 310 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 311 | Las Vegas Prostate Cancer Center | Las Vegas | Nevada | United States | 89113 |
| 312 | Las Vegas Urology - Sunset | Las Vegas | Nevada | United States | 89113 |
| 313 | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | United States | 89113 |
| 314 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 315 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
| 316 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 317 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 318 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 319 | GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 320 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 321 | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | United States | 89128 |
| 322 | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | United States | 89128 |
| 323 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 324 | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 325 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 326 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 327 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 328 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 329 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 330 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 331 | GenesisCare USA - Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 332 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 333 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 334 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 335 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 336 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 337 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 338 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 339 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 340 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 341 | Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | United States | 07920 |
| 342 | Memorial Sloan Kettering Monmouth | Middletown | New Jersey | United States | 07748 |
| 343 | Memorial Sloan Kettering Bergen | Montvale | New Jersey | United States | 07645 |
| 344 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 345 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
| 346 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 347 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 348 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 349 | Memorial Sloan Kettering Commack | Commack | New York | United States | 11725 |
| 350 | Memorial Sloan Kettering Westchester | Harrison | New York | United States | 10604 |
| 351 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 352 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 353 | Long Island Jewish Medical Center | New Hyde Park | New York | United States | 11040 |
| 354 | Memorial Sloan Kettering Cancer Center | New York | New York | United States | 10065 |
| 355 | University of Rochester | Rochester | New York | United States | 14642 |
| 356 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 357 | Memorial Sloan Kettering Nassau | Uniondale | New York | United States | 11553 |
| 358 | AdventHealth Infusion Center Asheville | Asheville | North Carolina | United States | 28803 |
| 359 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
| 360 | AdventHealth Infusion Center Haywood | Clyde | North Carolina | United States | 28721 |
| 361 | AdventHealth Hendersonville | Hendersonville | North Carolina | United States | 28792 |
| 362 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 363 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 364 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
| 365 | Toledo Clinic Cancer Centers-Bowling Green | Bowling Green | Ohio | United States | 43402 |
| 366 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 367 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 368 | Oncology Hematology Care Inc-Eden Park | Cincinnati | Ohio | United States | 45202 |
| 369 | Oncology Hematology Care Inc-Mercy West | Cincinnati | Ohio | United States | 45211 |
| 370 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 371 | Oncology Hematology Care Inc-Anderson | Cincinnati | Ohio | United States | 45230 |
| 372 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 373 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 374 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 375 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 376 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 377 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 378 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 379 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 380 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 381 | Oncology Hematology Care Inc-Healthplex | Fairfield | Ohio | United States | 45014 |
| 382 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 383 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 384 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 385 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 386 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 387 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 388 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 389 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 390 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 391 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 392 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 393 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 394 | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio | United States | 43537 |
| 395 | Dayton Physicians LLC-Signal Point | Middletown | Ohio | United States | 45042 |
| 396 | Saint Charles Hospital | Oregon | Ohio | United States | 43616 |
| 397 | Toledo Clinic Cancer Centers-Oregon | Oregon | Ohio | United States | 43616 |
| 398 | Dayton Physicians LLC-Wilson | Sidney | Ohio | United States | 45365 |
| 399 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 400 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 401 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 402 | Mercy Hospital of Tiffin | Tiffin | Ohio | United States | 44883 |
| 403 | ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | United States | 43606 |
| 404 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 405 | University of Toledo | Toledo | Ohio | United States | 43614 |
| 406 | Toledo Community Hospital Oncology Program CCOP | Toledo | Ohio | United States | 43617 |
| 407 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 408 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 409 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 410 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 411 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 412 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 413 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 414 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433 |
| 415 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 416 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 417 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 418 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 419 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 420 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 421 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 422 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 423 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 424 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 425 | Providence Willamette Falls Medical Center | Oregon City | Oregon | United States | 97045 |
| 426 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 427 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 428 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 429 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 430 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 431 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 432 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 433 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 434 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 435 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 436 | AnMed Health Cancer Center | Anderson | South Carolina | United States | 29621 |
| 437 | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | United States | 29316 |
| 438 | Prisma Health Cancer Institute - Easley | Easley | South Carolina | United States | 29640 |
| 439 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 440 | Greenville Health System Cancer Institute-Andrews | Greenville | South Carolina | United States | 29601 |
| 441 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 442 | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | United States | 29605 |
| 443 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 444 | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | United States | 29605 |
| 445 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 446 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 447 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 448 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 449 | Carolina Blood and Cancer Care Associates PA-Lancaster | Lancaster | South Carolina | United States | 29720 |
| 450 | Carolina Blood and Cancer Care Associates PA | Rock Hill | South Carolina | United States | 29732 |
| 451 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 452 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 453 | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | United States | 37067 |
| 454 | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States | 37204 |
| 455 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 456 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
| 457 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 458 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 459 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 460 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 461 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 462 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 463 | Farmington Health Center | Farmington | Utah | United States | 84025 |
| 464 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 465 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 466 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 467 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 468 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 469 | Saint George Regional Medical Center | Saint George | Utah | United States | 84770 |
| 470 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 471 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 472 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 473 | South Jordan Health Center | South Jordan | Utah | United States | 84009 |
| 474 | Fredericksburg Oncology Inc | Fredericksburg | Virginia | United States | 22401 |
| 475 | VCU Massey Cancer Center at Stony Point | Richmond | Virginia | United States | 23235 |
| 476 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 477 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 478 | Cancer Care Center at Island Hospital | Anacortes | Washington | United States | 98221 |
| 479 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 480 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 481 | Swedish Cancer Institute-Eastside Oncology Hematology | Bellevue | Washington | United States | 98005 |
| 482 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 483 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 484 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 485 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 486 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 487 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 488 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 489 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 490 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 491 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 492 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 493 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 494 | Minor and James Medical PLLC | Seattle | Washington | United States | 98104 |
| 495 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 496 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 497 | Kaiser Permanente Washington | Seattle | Washington | United States | 98112 |
| 498 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 499 | Swedish Medical Center-Cherry Hill | Seattle | Washington | United States | 98122-5711 |
| 500 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 501 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 502 | MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington | United States | 99216 |
| 503 | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington | United States | 99204 |
| 504 | Evergreen Hematology and Oncology PS | Spokane | Washington | United States | 99218 |
| 505 | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington | United States | 99218 |
| 506 | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | United States | 98405 |
| 507 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 508 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 509 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 510 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 511 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 512 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 513 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 514 | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | United States | 54301-3526 |
| 515 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 516 | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 517 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 518 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 519 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 520 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 521 | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin | United States | 54143 |
| 522 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 523 | Marshfield Medical Center | Marshfield | Wisconsin | United States | 54449 |
| 524 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 525 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 526 | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 527 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 528 | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 529 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
| 530 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 531 | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 532 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 533 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 534 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 535 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 536 | Big Horn Basin Cancer Center | Cody | Wyoming | United States | 82414 |
| 537 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 538 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 539 | Tom Baker Cancer Centre | Calgary | Alberta | Canada | T2N 4N2 |
| 540 | Clinical Research Unit at Vancouver Coastal Health Authority | Vancouver | British Columbia | Canada | V5Z 3P1 |
| 541 | QEII Health Sciences Centre/Nova Scotia Health Authority | Halifax | Nova Scotia | Canada | B3H 2Y9 |
| 542 | Kingston Health Sciences Centre | Kingston | Ontario | Canada | K7L 2V7 |
| 543 | CIUSSSEMTL-Hopital Maisonneuve-Rosemont | Montreal | Quebec | Canada | H1T 2M4 |
| 544 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 545 | Rambam Medical Center | Haifa | Israel | 31096 | |
| 546 | Shaare Zedek Medical Center | Jerusalem | Israel | 91031 | |
| 547 | Cancer Center-Metro Medical Center Bayamon | Bayamon | Puerto Rico | 00959-5060 | |
| 548 | Doctors Cancer Center | Manati | Puerto Rico | 00674 | |
| 549 | San Juan Community Oncology Group | San Juan | Puerto Rico | 00917 | |
| 550 | Centro Comprensivo de Cancer de UPR | San Juan | Puerto Rico | 00927 | |
| 551 | San Juan City Hospital | San Juan | Puerto Rico | 00936 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
- Canadian Cancer Trials Group
Investigators
- Principal Investigator: Mark R Litzow, ECOG-ACRIN Cancer Research Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2013-02229
- NCI-2013-02229
- ECOG-E1910
- E1910
- PE1910_A08PAMDREVW01
- E1910
- E1910
- U10CA180820
- U10CA021115
- U24CA196172