Aerobic Versus Resistive Training on Functional Capacity in Acute Myeloid Leukemia
Study Details
Study Description
Brief Summary
Sixty patients with AML from both sexes aged from 35-45 years were selected from hematology department in Nasser Institute Hospital where the study was conducted. Patients were randomly assigned into two groups equal in number. Group (A) underwent aerobic exercises in the form of cycling with 50-60% of maximum heart rate. Group (B) underwent resistive training conducted in the form of a series of exercises using free weights, and dumbles. Sessions were conducted three times /week for eight weeks. Six minutes' walk test (6MWT), 10 repetitions maximum test (10 RM), ventilatory function test, fatigue and quality of life (QOL) scales were used to assess functional capacity in both groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Aerobic Ex Group: Included 30 patients who underwent aerobic training with 50 %-60% of maximum heart rate in the form of cycling by Bicycle ergometer for eight weeks, three sessions/week.
Resistive Ex Group: Included 30 patients who underwent a resistive training which were conducted in the form of a series of exercises using free weights, and dumbles to increase the strength of arms, pectoral muscles, abdominal, back muscles and gluteal region. Patients carried out three sets of 20-30 dynamic repetitions or static isometric exercises for 40-60 seconds for each muscle group and rested 1-2 min between series. Sessions were conducted three sessions/week for eight weeks.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Aerobic exercise group Included 30 patients who underwent aerobic training with 50 %-60% of maximum heart rate in the form of cycling by Bicycle ergometer for eight weeks, three sessions/week. |
Other: Aerobic exercise
resistive training which were conducted in the form of a series of exercises using free weights, and dumbles to increase the strength of arms, pectoral muscles, abdominal, back muscles and gluteal region. Patients carried out three sets of 20-30 dynamic repetitions or static isometric exercises for 40-60 seconds for each muscle group and rested 1-2 min between series. Sessions were conducted three sessions/week for eight weeks.
Other Names:
|
| Active Comparator: Resistive exercise group Included 30 patients who underwent a resistive training which were conducted in the form of a series of exercises using free weights, and dumbles to increase the strength of arms, pectoral muscles, abdominal, back muscles and gluteal region. Sessions were conducted three sessions/week for eight weeks. |
Other: Aerobic exercise
resistive training which were conducted in the form of a series of exercises using free weights, and dumbles to increase the strength of arms, pectoral muscles, abdominal, back muscles and gluteal region. Patients carried out three sets of 20-30 dynamic repetitions or static isometric exercises for 40-60 seconds for each muscle group and rested 1-2 min between series. Sessions were conducted three sessions/week for eight weeks.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Six minutes walking Distance [It is performed before and after the study(8 weeks interval) for both groups]
which used to measure the distance the patient was able to walk over a total of six minutes According to American thorax society guidelines; patients were instructed to walk as fast as long as possible , in a 30 meters obstacle free corridor limited by turnaround cones and distance was calculated
- 10 repetition maximum test [It is performed before and after the study(8 weeks interval) for both groups]
which the greatest amount of weight a person can lift number of times. The amount of weight that can be lifted exactly 10 times is 10 RM
- Vital capacity [It is performed before and after the study(8 weeks interval) for both groups]
was measured by using electronic spirometry used to conduct ventilatory function testing
Secondary Outcome Measures
- Maximum oxygen consumption [It is performed before and after the study(8 weeks interval) for both groups]
Results of (6MWT) was used to calculate Vo2 max by using Cahalin equation as follows; Vo2 max = 0.03x distance in meters +3.98, in which distance is obtained from (6MWT)
- Fatigue assessment scale (FAS) [It is performed before and after the study(8 weeks interval) for both groups]
FAS is a 10-item scale evaluating symptoms of chronic fatigue
- Quality of life questionnaire (QOL) [It is performed before and after the study(8 weeks interval) for both groups]
was used to evaluate the quality of life before and after training for both groups.The Quality of Life Instrument (CANCER PATIENT/CANCER SURVIVOR VERSION) is a forty one-item ordinal scale. The scoring should be based on a scale of 0 = worst outcome to 10 = best outcome
Eligibility Criteria
Criteria
Inclusion Criteria:
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Acute myeloid leukemia survivors from both sexes
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Their age ranged from 35-45 years.
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Patients were in remission stage contains less than 5% blast cells in their bone marrow, absolute neutrophil count (>1000/microL), platelet count(>100,000/microL),and independence from red cell transfusion.
Exclusion Criteria:
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Extramedullary leukemia
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musculoskeletal deformities
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severe anemia (hemoglobin less than 8g/dl).
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Autoimmune thrombocytopenia (platelets less than 10000UL or leucocytes count more than 3000UL).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Faculty of Physical Therapy | Giza | Cairo | Egypt | 002 |
Sponsors and Collaborators
- Cairo University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MA201918