Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

Sponsor

Marlous Hall (Other)

Overall Status

Completed

CT.gov ID

NCT03037255

Collaborator

(none)

693,633

Enrollment

216

Duration (Months)

Study Details

Study Description

Brief Summary

This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

Condition or Disease	Intervention/Treatment	Phase
Acute Myocardial Infarction Diabetes Mellitus Peripheral Vascular Disease Chronic Heart Failure Cerebrovascular Disease Chronic Renal Failure Chronic Obstructive Pulmonary Disease	Other: long term conditions

Detailed Description

Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

693633 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Association of Long-term Conditions With Survival Following Acute Myocardial Infarction in England and Wales

Study Start Date :

Jan 1, 2003

Actual Primary Completion Date :

Dec 1, 2013

Actual Study Completion Date :

Jan 1, 2021

Outcome Measures

Primary Outcome Measures

Number of patients who died from any cause by the end of the study censoring period [8.4 years]
Death data was obtained from national death records from the Office for National Statistics

Secondary Outcome Measures

Number of patients who received guideline recommended therapy during the study period [Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days]
All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed.