ESVO: Emergent Stenting In Acute Vertebrobasilar Occlusions
Study Details
Study Description
Brief Summary
In the acute posterior circulation strokes, the vertebrobasilar occlusions frequently related to worse outcomes than the anterior ones. However, few studies mentioned the benefit and safety of the emergent stenting in the successful recanalization at these complex occlusions. The investigators investigated whether the improvement of clinical outcome was achieved in postprocedural 3-month.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
Acute ischemic stroke in posterior circulation account for nearly 20 - 25%, in which large vessel occlusions (LVOs) occur 0.8% - 5.7% of two circulation strokes. Although mechanical thrombectomy (MT) has recently been the gold standard in LVOs treatment, the futile recanalization (defined as unfavorable outcome despite early successful recanalization of target artery) rate was showed in posterior circulation higher than in anterior one. Multiple randomized controlled trials (BEST, BASICS, BAOCHE, ATTENTION) have recently reported the benefit of emergent stenting for acute vertebrobasilar occlusions stroke in order to support the successful recanalization in the setting of failure of mechanical thrombectomy. Moreover, the successful recanalization is one of the independent predictors of favorable outcomes. However, the use of the loading dose dual antiplatelet therapy and peri-procedural complications made the safety of emergent stenting remain uncertain. Therefore, the investigators aimed to investigate the impact of emergent stenting on the improved recanalization and clinical outcome in vertebrobasilar occlusions.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Emergent Stenting Emergent Stenting In Acute Vertebrobasilar Occlusions |
Procedure: Emergent Stenting
Emergent Stenting In Acute Vertebrobasilar Occlusions
Other Names:
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Outcome Measures
Primary Outcome Measures
- The favorable 3-month outcome rate [3 months]
The favorable 3-month outcome rate was accessed by modified Rankin Score (mRS), which comprised of included good (mRS 0 - ≤ 2) and fair (mRS 3).
Secondary Outcome Measures
- The symptomatic intracerebral hemorrhage rate [24 hours after emergent stenting]
The symptomatic intracerebral hemorrhage was defined as patient's intracerebral hemorrhage with postprocedural mRS ≥ 5 and there were no other evident causes for the increased mRS
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age > 18 years old
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Onset to treatment time < 24 hours
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NIHSS ≥ 6
Exclusion Criteria:
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Premorbid mRS > 2
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Loss to follow up after discharge
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Can Tho Stroke International Services Hospital | Can Tho | Vietnam | 900000 |
Sponsors and Collaborators
- Can Tho Stroke International Services Hospital
Investigators
- Study Director: Cuong Tran Chi, Doctor, Can Tho Stroke International Services General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Le MT, Tran CC, Nguyen-Luu G, Ngo MT, Nguyen-Dao NH, Duong-Hoang L, Mai-Van M, Nguyen MD. Rescue stenting after the failure of intravenous thrombolysis and bridging thrombolysis: an initial Vietnamese report. Eur Rev Med Pharmacol Sci. 2022 Dec;26(24):9162-9169. doi: 10.26355/eurrev_202212_30667.
- Tran CC, Le MT, Baxter BW, Nguyen-Luu G, Ngo MT, Nguyen-Dao NH, Duong-Hoang L, Mai-Van M, Nguyen MD. Rescue intracranial stenting in acute ischemic stroke: a preliminary Vietnamese study. Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):6944-6952. doi: 10.26355/eurrev_202210_29875.
- ESVO Study