Adebrelimab and Fruquintinib Combined With Paclitaxel/Albumin Paclitaxel for Advanced Gastric Cancer

Sponsor

Tianjin Medical University Cancer Institute and Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT06102772

Collaborator

(none)

Enrollment

Location

Anticipated Duration (Months)

0.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This is a prospective, single-center, open, single-arm clinical study to observe and evaluate the efficacy and safety of Fruquintinib and Adebrelimab combined with paclitaxel/albumin paclitaxel for second-line treatment of advanced gastric cancer.

Condition or Disease	Intervention/Treatment	Phase
Gastric Cancer	Drug: Adebrelimab，Fruquintinib

Detailed Description

The benefits of immunotherapy in first-line treatment for gastric cancer patients whose tumor tissue CPS<5 are limited. And some patients have not been treated by immunotherapy in the first-line treatment in clinical practice. This study intends to enroll first-line patients with advanced gastric cancer who have not been treated with PD-1 antibody, and explore the effectiveness and safety of second-line PD-L1 antibody combined with Fruquintinib and paclitaxel/albumin-paclitaxel, providing clues for the application of PD-L1 antibody in advanced gastric cancer.

Study Design

Study Type:

Observational

Anticipated Enrollment :

30 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Phase II Clinical Study of Adebrelimab and Fruquintinib Combined With Paclitaxel/Albumin Paclitaxel for Second-line Treatment of Advanced Gastric Cancer

Anticipated Study Start Date :

Nov 10, 2023

Anticipated Primary Completion Date :

Oct 10, 2026

Anticipated Study Completion Date :

Oct 10, 2026

Arms and Interventions

Arm	Intervention/Treatment
Adebrelimab, Fruquintinib combined with paclitaxel Fruquintinib 4mg d1-14, q3w Paclitaxel 150mg/m2, d1, q3w / Albumin paclitaxel 125mg/m2, d1, d8, q3w PD-L1 antibody (Adebrelimab) 20 mg/kg, d1, q3w	Drug: Adebrelimab，Fruquintinib Adebrelimab，Fruquintinib combined with chemotherapy

Arm

Intervention/Treatment

Adebrelimab, Fruquintinib combined with paclitaxel

Fruquintinib 4mg d1-14, q3w Paclitaxel 150mg/m2, d1, q3w / Albumin paclitaxel 125mg/m2, d1, d8, q3w PD-L1 antibody (Adebrelimab) 20 mg/kg, d1, q3w

Drug: Adebrelimab，Fruquintinib

Adebrelimab，Fruquintinib combined with chemotherapy

Outcome Measures

Primary Outcome Measures

Progression Free Survival [From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 36 months]
Time from the start of treatment to the progression of the disease

Secondary Outcome Measures

Disease Control rate [From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months]
The proportion of CR,PR and SD
The Overall Response Rate [Time Frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months]
The proportion of CR and PR
Overall survival [From date of randomization until the date of death from any cause or the last visit date, whichever came first, assessed up to 60 months]
Time from the start of treatment to the occurrence of death

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age ≥18 years old.
The ECOG score is 0-1 and does not deteriorate within 7 days.
Patients with histologically confirmed, metastatic, or unresectable locally advanced gastric cancer or GEJ adenocarcinoma.
Previously received one systemic chemotherapy regimen for this cancer and progressed; Or have received adjuvant chemotherapy, but have disease progression or recurrence within 6 months after the end of treatment.
There was no PD-1/PD-L1 inhibitor exposure in the first line.
Measurable lesions that meet RECIST 1.1 criteria.
Have adequate organ and bone marrow function, laboratory tests meet the following requirements:
HGB≥90g/L;
NEUT≥1.5×10^9/L;
PLT ≥80×10^9/L;
TBIL≤1.5 times upper limit of normal value (ULN);
ALT and AST≤2.5 x ULN; In liver metastasis, ALT and AST≤5×ULN;
Endogenous creatinine clearance ≥50ml/min (Cockcroft-Gault formula);
Urinary protein < (++), or 24-hour urinary protein volume < 1.0 g.
Normal coagulation function, no active bleeding
International standardized ratio INR≤1.5;
Partial thromboplastin time APTT≤1.5 ULN.
Women of childbearing age must undergo a negative pregnancy test (serum or urine) within 14 days prior to enrollment and voluntarily use an appropriate method of contraception during the observation period and within 8 weeks after the last dose of the study drug; For men, they should be surgically sterilized or consent to an appropriate method of contraception during the observation period and for 8 weeks after the last administration of the study drug.
Expected survival ≥3 months.
Patients voluntarily joined the study and signed an informed consent form (ICF).
It is expected that the compliance is good, and the efficacy and adverse reactions can be followed up according to the protocol requirements.

Exclusion Criteria:

Previous treatment with VEGFR inhibitors;
Previously received paclitaxel therapy (except for those who received paclitaxel therapy in neoadjuvant or adjuvant therapy, and the treatment ended more than 6 months after the disease progression);
Receive live vaccine within 4 weeks prior to enrollment or possibly during the study period;
Had active autoimmune disease or history of autoimmune disease within 4 weeks prior to enrollment;
Previously received allogeneic bone marrow transplantation or organ transplantation;
Hypertension that could not be controlled by drugs before enrollment was defined as: systolic blood pressure ≥150 mmHg and/or diastolic blood pressure ≥90 mmHg;
Had any disease or condition affecting drug absorption before enrollment, or the patient could not take drugs orally;
Gastrointestinal diseases such as active ulcer of stomach and duodenum, ulcerative colitis, or active bleeding of unexcised tumors, or other conditions that may cause gastrointestinal bleeding or perforation as determined by researchers before enrollment;
Patients with evidence or history of significant bleeding tendency within 3 months prior to enrollment (bleeding within 3 months > 30 mL, hematemesis, stool, stool blood), hemoptysis, or thromboembolic events (including stroke events and/or transient ischemic attacks) within 12 months;
Clinically significant cardiovascular disease, including but not limited to acute myocardial infarction, severe/unstable angina pectoris, or coronary artery bypass grafting within 6 months prior to enrollment; New York Heart Association (NYHA) Grades for Congestive Heart Failure > Level 2; Ventricular arrhythmias requiring medical treatment; LVEF (Left ventricular Ejection Fraction) < 50%;
Active or uncontrolled severe infection (≥CTCAE v5.0 grade 2 infection);
Known human immunodeficiency virus (HIV) infection. Known history of clinically significant liver disease, including viral hepatitis [Known hepatitis B virus (HBV) carriers must rule out active HBV infection, i.e., positive HBV DNA (>1×104 copies /mL or > 2000 IU/ mL); known hepatitis C virus infection (HCV) and HCV RNA positive (>1×103 copies /mL);
Any other medical condition, clinically significant metabolic abnormality, physical abnormality or laboratory abnormality, which, in the investigator's judgment, reasonably suspects that the patient has a medical condition or condition that is not suitable for the use of the investigational drug (such as having seizures and requiring treatment), or which would affect the interpretation of the study results or place the patient at high risk;
The patients considered by the investigators to be unsuitable for inclusion in this study.