The Effect of Adenomoyosis on Pregnancy Outcomes
Study Details
Study Description
Brief Summary
Adenomyosis can be defined as the settling of endometrial gland cells in the myometrium and deformity in the uterus and the prevalence of adenomyosis is according to the patient population and countries around 20%. There are recent publications reporting that this rate increases up to 50% in women dealing with infertility. In adenomyosis, where uterine morphology is affected, it is not thought that the uterus, which is expected to provide many morphological adaptations during pregnancy, will not be affected. Therefore, in this prospective study, it was planned to investigate the effects of adenomyosis during pregnancy.
For this study the presence of adenomyosis will be questioned by using ultrasonographic morphological uterine limitation (MUSA) in women who apply to the outpatient clinic with suspicion of pregnancy and undergo transvaginal ultrasonography for the diagnosis of pregnancy before sixth gestational week.
Patients will be divided into two groups according to the presence of adenomyosis and pregnancy complications such as preterm labor, premature rupture of membranes, cesarean section rates, preeclampsia, fetal malpresentation and preeclampsia will be compared between the groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Adenomyosis Group
|
Other: Non intervention
During the study there is no extra intervention planned for the participants.
|
| Non-adenomyosis Group
|
Other: Non intervention
During the study there is no extra intervention planned for the participants.
|
Outcome Measures
Primary Outcome Measures
- Pregnancy complication [15 month]
Preterm labour
Secondary Outcome Measures
- Pregnancy complication [16 month]
placental anomalies
- Pregnancy complication [17 month]
preeclampsia, eclampsia
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age between 18-35 years
-
Being diagnosed before the 6th gestational week
-
Having all pregnancy follow-ups and deliveries in our hospital
Exclusion Criteria:
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Previous uterine surgery
-
Multiple pregnancies
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Pregnant women with uterine malformations
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Pregnant women with fetal anomalies
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Those who got pregnant using assisted reproductive technique
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Tepecik Education and Research Hospital | İzmir | Turkey |
Sponsors and Collaborators
- Tepecik Training and Research Hospital
Investigators
- Study Director: Ahkam Göksel Kanmaz, Assoc. Prof., Tepecik Education and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Harada T, Taniguchi F, Amano H, Kurozawa Y, Ideno Y, Hayashi K, Harada T; Japan Environment and Children's Study Group. Adverse obstetrical outcomes for women with endometriosis and adenomyosis: A large cohort of the Japan Environment and Children's Study. PLoS One. 2019 Aug 2;14(8):e0220256. doi: 10.1371/journal.pone.0220256. eCollection 2019.
- Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012.
- TepecikTRH-001