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LY317615 Plus Capecitabine in Treating Patients With Advanced Solid Tumors

Sponsor
Jonsson Comprehensive Cancer Center (Other)
Overall Status
Completed
CT.gov ID
NCT00052273
Collaborator
Eli Lilly and Company (Industry)
16
Enrollment
1
Location
34
Duration (Months)
0.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: LY317615 may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth and by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining LY317615 with capecitabine may kill more tumor cells.

PURPOSE: Phase I trial to study the effectiveness of combining LY317615 with capecitabine in treating patients who have advanced solid tumors.

Condition or Disease Intervention/Treatment Phase
Phase 1

Detailed Description

OBJECTIVES:

  • Determine the maximum tolerated dose and the recommended phase II dose of LY317615 and capecitabine in patients with advanced solid tumors.

  • Determine the safety profile of this regimen in these patients.

  • Determine the pharmacokinetics of this regimen in these patients.

  • Determine, preliminarily, the antitumor activity of this regimen in these patients.

  • Determine the effects of LY317615 on potential angiogenic surrogate markers in these patients.

OUTLINE: This is a dose-escalation study.

Patients receive oral LY317615 daily on days 1-14 (course 1 only). Beginning with course 2, patients receive oral LY317615 daily on days 1-21 and oral capecitabine twice daily on days 1-14. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of LY317615 and capecitabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Once the MTD is determined, additional patients are treated at the recommended phase II dose.

Patients are followed at 30 days after the last dose of study drug.

PROJECTED ACCRUAL: A total of 12-36 patients will be accrued for this study.

Study Design

Study Type:
Interventional
Actual Enrollment :
16 participants
Primary Purpose:
Treatment
Official Title:
A Phase I Dose Escalation Study With Oral LY317615 in Combination With Capecitabine in Advanced Cancer Patients
Study Start Date :
Dec 1, 2002
Actual Primary Completion Date :
Nov 1, 2004
Actual Study Completion Date :
Oct 1, 2005

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Histologically confirmed solid tumor that is refractory to standard therapy or for which no standard therapy exists

    • Measurable or evaluable disease

    • 18 and over

    • ECOG 0-2

    • Hematopoietic

    • Absolute neutrophil count at least 1,500/mm^3

    • Platelet count at least 100,000/mm^3

    • Hemoglobin at least 9 g/dL (erythrocyte transfusions allowed)

    • Hepatic

    • Bilirubin no greater than 1.5 times upper limit of normal (ULN)

    • ALT and AST no greater than 2.5 times ULN (5 times ULN if liver metastases present)

    • Renal

    • Creatinine clearance at least 50 mL/min

    • Potassium at least 3.4 mEq/L

    • Calcium at least 8.4 mg/dL

    • Magnesium at least 1.2 mEq/L

    • Cardiovascular

    • QTc interval no greater than 450 msec in males

    • QTc interval no greater than 470 msec in females

    • No other electrocardiogram abnormalities

    • Able to swallow capsules

    • Negative pregnancy test

    • Fertile patients must use effective contraception during and for 3-6 months after study

    • Endocrine therapy

    • At least 4 weeks since prior anticancer hormonal therapy

    • At least 6 weeks since prior bicalutamide

    • At least 4 weeks since prior flutamide or nilutamide

    • Concurrent luteinizing hormone-releasing hormone analog therapy (e.g., leuprolide or goserelin) allowed for patients with prostate cancer if started before study entry

    • At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin).

    • Radiotherapy

    • At least 4 weeks since prior radiotherapy

    • At least 2 weeks since prior palliative radiotherapy

    • Recovered from prior therapy

    • Other

    • At least 4 weeks since prior investigational anticancer therapy

    • At least 4 weeks since other prior anticancer therapy

    • At least 30 days since prior experimental drugs

    Exclusion Criteria:

    • known untreated or symptomatic CNS metastases

    • concurrent hematologic malignancies

    • gastrointestinal disorder that would interfere with oral drug absorption

    • serious concurrent systemic disorder

    • compliance issues that would preclude study

    • geographical conditions that would preclude study

    • active infection

    • prior hypersensitivity to any component of study drugs

    • pregnant or nursing

    • concurrent immunotherapy

    • concurrent routine filgrastim (G-CSF)

    • other concurrent chemotherapy

    • other concurrent hormonal therapy

    • concurrent radiotherapy (including palliative therapy)

    • other concurrent experimental medications

    • other concurrent anticancer therapy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Jonsson Comprehensive Cancer Center, UCLA Los Angeles California United States 90095-1781

    Sponsors and Collaborators

    • Jonsson Comprehensive Cancer Center
    • Eli Lilly and Company

    Investigators

    • Principal Investigator: Carolyn Britten, MD, Jonsson Comprehensive Cancer Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Jonsson Comprehensive Cancer Center
    ClinicalTrials.gov Identifier:
    NCT00052273
    Other Study ID Numbers:
    • CDR0000258138
    • UCLA-0206061
    • LILLY-H6Q-MC-JCAH
    • NCI-G02-2132
    First Posted:
    Jan 27, 2003
    Last Update Posted:
    Aug 3, 2020
    Last Verified:
    Aug 1, 2012
    Keywords provided by Jonsson Comprehensive Cancer Center
    unspecified adult solid tumor
    protocol specific
    Additional relevant MeSH terms:
    Capecitabine

    Study Results

    No Results Posted as of Aug 3, 2020