OPEX: Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise

• Sponsor: University Hospital, Clermont-Ferrand (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT02938117
• Collaborator: (none)
• Enrollment: 30
• Location: 1
• Arms: 2
• Duration (Months): 36
• Patients Per Site Per Month: 0.8

Study Details

Study Description

Brief Summary

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition

Condition or Disease	Intervention/Treatment	Phase
Adults; BMI>35	Other: cycling exercises	N/A

Detailed Description

Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 30 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Participant)
• Official Title: Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise
• Study Start Date: Jan 1, 2017
• Anticipated Primary Completion Date: Dec 1, 2019
• Anticipated Study Completion Date: Jan 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: CON : concentric cycling exercise Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise	Other: cycling exercises
Experimental: EXC : eccentric cycling exercise Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise	Other: cycling exercises

Outcome Measures

Primary Outcome Measures

1. change in total body fat mass (Dual X ray Absorptiometry) [before and after the 12 weeks training program]

Secondary Outcome Measures

1. aerobic capacities (VO2max) [before and after the 12 weeks training program]

2. isometric muscular lower limbs strength [before and after the 12 weeks training program]

3. isokinetic muscular lower limbs strength [before and after the 12 weeks training program]

4. rest energy expenditure (indirect calorimetry) [before and after the 12 weeks training program]

5. biological parameters (plasma lipid profile) [before and after the 12 weeks training program]

6. biological parameters (insulin-resistance) [before and after the 12 weeks training program]

7. physical activity [before and after the 12 weeks training program]

   (questionnaires)

8. physical activity [before and after the 12 weeks training program]

   (actimetry)

9. food intakes [before and after the 12 weeks training program]

   (measurements)

10. food intakes [before and after the 12 weeks training program]

    (questionnaires)

11. quality of life (questionnaires) [before and after the 12 weeks training program]

12. segmental body composition [before and after the 12 weeks training program]

    (segmental fat and fat free mass)

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 35 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• • Adults

• Obese (BMI>35)

• Inactive (<10 METS/h/week)

• No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria:

• (BMI<35)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	CHU Clermont-Ferrand	Clermont-Ferrand		France	63003

Sponsors and Collaborators

• University Hospital, Clermont-Ferrand

Investigators

• Principal Investigator: Valérie JULIAN, University Hospital, Clermont-Ferrand

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University Hospital, Clermont-Ferrand
• ClinicalTrials.gov Identifier: NCT02938117
• Other Study ID Numbers: CHU-0284; 2016-A01185-46
• First Posted: Oct 19, 2016
• Last Update Posted: Oct 19, 2016
• Last Verified: Oct 1, 2016

• Keywords provided by University Hospital, Clermont-Ferrand: obesity; eccentric exercise; body composition; training program
• Additional relevant MeSH terms: Overweight

Study Results

No Results Posted as of Oct 19, 2016