WHATELSE: Decision to Limit or Withdraw Specific Therapies for Advanced Cancer and Hematological Malignancies.
Study Details
Study Description
Brief Summary
The decision to limit or withdraw specific therapies (DLWT) in patients with advanced cancer is a complex process that is always painful for patients, relatives and professionals. For more than 10 years, shared decision making has been more and more emphasized. However, few data in the literature rely on clinical research. In order to understand their difficulties and issues, this study explores the determinants and modalities of DLWT and analyses the feasibility of different methods for investigating this decision making process.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This study explores the decision-making process for patients with advanced cancer when the question to imit or withdraw specific therapies (DLWT) is raised, with a cross-analysis of physicians and pts points of view.
This study took place in 5 oncology and hematology units : 2 university hospitals, 1 general hospital, 1 cancer center and 1 private hospital. The study included two different approaches: an epidemiological section to identify the prevalence of these situations in different institutions and a qualitative study section exploring factors influencing the decision process. The epidemiological analysis included all hospitalized patients identified with advanced cancer for whom the question of DLWT was raised in a given week or during the two weeks preceding the investigation.
The qualitative analysis was based on interviews with the referent oncologist (or hematologist) and his patient (conducted by a physician and a psychologist respectively) as well as interviews with other partners involved in the situation (care staff and relatives) depending on the center. Researchers also participated in multidisciplinary meetings and monitored changes in the decision over a three month period.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Qualitative research Semi-structured interviews |
Other: interviews
face-to-face interviews with the referent oncologist (or hematologist) and his patient (conducted by a physician and a psychologist respectively) as well as interviews with other partners involved in the situation (care staff and relatives)
|
Outcome Measures
Primary Outcome Measures
- interviews with physicians, patients and relatives [6 months]
A thematic analysis induces the creation of a set of themes and concepts clustered by relevance into a tree structure. The thematic tree structure constitutes the dataset of interest.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients with advanced cancer
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Existence of a questioning about DLWT
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Absence of guide lines
Exclusion Criteria:
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Incapacity of the patient to participate to an interview
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Absence of informed consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centre Hospitalier Universitaire de Besançon | Besancon | France | 25000 | |
| 2 | Centre Hospitalier de Colmar | Colmar | France | 68000 | |
| 3 | Clinique Drevon | Dijon | France | 21000 | |
| 4 | Centre Hospitalier Universitaire St Antoine | Paris | France | 75012 | |
| 5 | Centre de Luttre Contre le Cancer Alexis Vautrin | Vandœuvre-lès-Nancy | France | 54519 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Besancon
- Centre Hospitalier Universitaire Saint Antoine, Paris
- Centre de Lutte Contre le Cancer Alexis Vautrin, Vandoeuvre les Nancy
- Hospital Center De Colmar
- Clinique Devron, Dijon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- WHATELSE