Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Recruiting
• CT.gov ID: NCT04181060
• Collaborator: (none)
• Enrollment: 300
• Locations: 519
• Arms: 2
• Anticipated Duration (Months): 58.3
• Patients Per Site: 0.6
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Condition or Disease	Intervention/Treatment	Phase
Advanced Lung Non-Squamous Non-Small Cell Carcinoma; Metastatic Lung Non-Squamous Non-Small Cell Carcinoma; Recurrent Lung Non-Squamous Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8	Biological: Bevacizumab; Drug: Osimertinib	Phase 3

Detailed Description

PRIMARY OBJECTIVE:

1. To evaluate progression-free survival (PFS) of osimertinib (AZD9291) and bevacizumab versus osimertinib (AZD9291) alone as first-line treatment for patients with metastatic EGFR-mutant lung cancers.

SECONDARY OBJECTIVES:

1. To evaluate overall survival (OS). II. To evaluate best objective response rate and duration of objective response.

2. To evaluate time to central nervous system (CNS) progression and CNS PFS. IV. To evaluate toxicity of the combination regimen.

CORRELATIVE OBJECTIVES:

1. To characterize mechanisms of resistance to osimertinib (AZD9291) and osimertinib (AZD9291) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA).

2. To assess for ctDNA clearance on study treatment and associate ctDNA clearance with clinical outcomes.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive osimertinib orally (PO) once daily (QD) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive osimertinib PO QD on days 1-21 and bevacizumab intravenously (IV) over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 10 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 300 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Randomized Phase III Study of Combination Osimertinib (AZD9291) and Bevacizumab Versus Osimertinib (AZD9291) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)
• Actual Study Start Date: Oct 22, 2020
• Anticipated Primary Completion Date: Sep 1, 2025
• Anticipated Study Completion Date: Sep 1, 2025

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Arm A (osimertinib) Patients receive osimertinib PO QD on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Drug: Osimertinib; Given PO; Other Names: AZD-9291 AZD9291 Mereletinib Tagrisso
Experimental: Arm B (osimertinib, bevacizumab) Patients receive osimertinib PO QD on days 1-21 and bevacizumab IV over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Biological: Bevacizumab; Given IV; Other Names: ABP 215 Anti-VEGF Anti-VEGF Humanized Monoclonal Antibody Anti-VEGF Monoclonal Antibody SIBP04 Anti-VEGF rhuMAb Avastin Bevacizumab awwb Bevacizumab Biosimilar ABP 215 Bevacizumab Biosimilar BEVZ92 Bevacizumab Biosimilar BI 695502 Bevacizumab Biosimilar CBT 124 Bevacizumab Biosimilar CT-P16 Bevacizumab Biosimilar FKB238 Bevacizumab Biosimilar GB-222 Bevacizumab Biosimilar HD204 Bevacizumab Biosimilar HLX04 Bevacizumab Biosimilar IBI305 Bevacizumab Biosimilar LY01008 Bevacizumab Biosimilar MIL60 Bevacizumab Biosimilar Mvasi Bevacizumab Biosimilar MYL-1402O Bevacizumab Biosimilar QL 1101 Bevacizumab Biosimilar RPH-001 Bevacizumab Biosimilar SCT501 Bevacizumab Biosimilar Zirabev Bevacizumab-awwb Bevacizumab-bvzr BP102 BP102 Biosimilar HD204 Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer Mvasi MYL-1402O Recombinant Humanized Anti-VEGF Monoclonal Antibody rhuMab-VEGF SCT501 SIBP 04 SIBP-04 SIBP04 Zirabev ; Drug: Osimertinib; Given PO; Other Names: AZD-9291 AZD9291 Mereletinib Tagrisso

Outcome Measures

Primary Outcome Measures

1. Progression-free survival (PFS) [From randomization to documented disease progression per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or death from any cause, whichever occurs first, assessed up to 10 years]

   Will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. PFS will use a logrank test stratified on the randomization stratification factors with a one-sided type I error rate of 2.5%.

Secondary Outcome Measures

1. Overall survival (OS) [From randomization to death from any cause, assessed up to 10 years]

   Will be estimated using the Kaplan-Meier method, and Cox proportional hazards models will be used to estimate the treatment hazard ratios. OS will be tested at the one-sided 10% level.

2. Best objective response rate [Up to 10 years]

   Best objective response will be evaluated via RECIST 1.1 criteria. Will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes.

3. Time to central nervous system progression [From study randomization to evidence of central nervous system progressive disease, with death and progression as competing events, assessed up to 10 years]

   Will be estimated using competing risks methodology, adjusting for death and progression as competing events. Regular central nervous system imaging will occur when patients are on treatment. After they discontinue study treatment, central nervous system imaging will be symptom-prompted during follow up.

4. Central nervous system progression-free survival [From study randomization to evidence of central nervous system progressive disease or death from any cause, whichever occurs first, assessed up to 10 years]

   Will be estimated using the Kaplan-Meier method.

5. Incidence of adverse events [Up to 30 days after the last administration of investigational agent]

   Toxicity will be determined using the Common Terminology Criteria for Adverse Events (CTCAE). Will be compared using Fisher's exact tests with a one-sided type I error rate of 2.5%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes.

Other Outcome Measures

1. Mechanisms of resistance to AZD9291 (osimertinib) and AZD9291 (osimertinib) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA) [Up to 10 years]

   Preliminary analyses of these data will utilize tests for association comparing the frequency of a particular genomic aberration at baseline and at progression (for example, using McNemar's test) and association between alterations and baseline characteristics (for example, using Fisher's exact test). More sophisticated analyses may include multivariable logistic regression modeling and/or competing risks analysis.

2. ctDNA clearance on study treatment [Up to 10 years]

   Will assess ctDNA clearance on study treatment and associate ctDNA clearance with clinical outcomes. Cox regression analysis will be used to assess whether EGFR ctDNA clearance is an independent predictor for PFS (and OS), adjusted by treatment effect, the presence of brain metastasis (yes versus [vs.] no), EGFR exon 19 deletion/L858R vs other, Eastern Cooperative Oncology Group (ECOG) performance status (0-1 vs 2) and other possible clinical and biological risk factors.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC)

• Patient must have advanced disease, defined as - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria

• Patient must have somatic activating sensitizing mutation in EGFR (e.g. but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Test results originating from a Clinical Laboratory Improvement Act (CLIA)-certified or similarly accredited laboratory are acceptable; no specific assay is mandated. Plasma, cytology, or tumor tissue can be utilized for mutation testing

• Patients that have received prior radiation therapy are eligible. Radiation (limited field stereotactic radiation or conventional radiation) must have been completed at least one week prior to study drug initiation and more extensive field radiation (i.e., whole-brain radiotherapy [WBRT]) must have been completed at least two weeks prior to drug initiation

• Patient must have measurable disease. Baseline measurements of sites of disease must be obtained within 4 weeks prior to study registration. If a potential target lesion is previously irradiated without subsequent growth and/or is radiated after the imaging from which baseline measurements are obtained, they cannot be included as target lesions, and additional target lesions are required to meet criteria for measurable disease

• Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

• All females of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy

• A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

• Patient of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for 2 weeks prior to the start of treatment, while on study treatment, and for

• 6 weeks after the last dose of protocol treatment for female patients on the osimertinib (AZD9291) alone arm

• 4 months after the last dose of protocol treatment for male patients on osimertinib (AZD9291) alone arm

• 6 months after the last dose of protocol treatment for all patients on osimertinib (AZD9291) plus bevacizumab combination arm

• NOTE: Female patients should also not breastfeed while on treatment and for 6 months after the last dose bevacizumab

• Leukocytes >= 3,000/mcL (obtained =< 14 days prior to registration)

• Absolute neutrophil count >= 1,500/mcL (obtained =< 14 days prior to registration)

• Platelets >= 100,000/mcL (obtained =< 14 days prior to registration)

• Hemoglobin >= 9 g/dL (obtained =< 14 days prior to registration)

• Total bilirubin and creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 14 days prior to registration)

• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 14 days prior to registration)

• Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

• For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

• Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

• Patients with treated brain metastases are eligible if neurologically stable without glucocorticoid therapy after the stated washout period from radiation therapy (RT) or surgery provided the metastatic lesions are non-hemorrhagic

• Patients with untreated brain metastases or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required provided the metastatic lesions are non-hemorrhagic and are neurologically stable without glucocorticoid therapy

• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

• Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better

• Patient must have the ability to understand and the willingness to sign a written informed consent document and comply with study requirements

Exclusion Criteria:

• Patient must not have received any prior treatment with an EGFR TKI or with an anti-VEGF agent

• Patient must not have any risk factors for anti-VEGF administration, specifically, hemoptysis, active cardiovascular disease, uncontrolled hypertension, significant proteinuria (screening urinalysis > 300 mg/dl) and tumor invading major blood vessels

• Patient must not have had any prior systemic treatment for metastatic disease

• Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used

• Patient must not have had treatment with any investigational drug within five half-lives or 3 months (whichever is greater), prior to study initiation

• Patient must not be currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4. For any patient currently receiving such inducers of CYP3A4, they must discontinue use prior to first dose of study treatment. All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4

• Patient must not have any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of registration, with the exception of alopecia and grade 2 prior platinum-therapy-related neuropathy

• Patient must not have any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator's opinion makes it challenging for the patient to participate in the study. Screening for chronic conditions is not required

• Patient must not have refractory nausea and vomiting, chronic gastrointestinal diseases, the inability to swallow the osimertinib tablets or previous significant bowel resection that would preclude adequate absorption of osimertinib

• Patient must not have a medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease

• Patient must not have a history of hypersensitivity to active or inactive excipients of osimertinib or drugs with a similar chemical structure or class to osimertinib

• Patient must not have mean resting corrected QT interval (QTc) > 470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc value (using Bezet's correction)

• Patient must not have any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g. complete left bundle branch block, third degree heart block and second-degree heart block

• Patient must not have any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: potassium < lower limit of normal [LLN]; magnesium < LLN; calcium < LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval and cause torsades de pointes

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
2	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
3	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
4	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
5	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
6	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
7	Katmai Oncology Group	Anchorage	Alaska	United States	99508
8	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
9	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
10	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
11	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
12	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
13	NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
14	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
15	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
16	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
17	Kaiser Permanente Dublin	Dublin	California	United States	94568
18	Kaiser Permanente-Fremont	Fremont	California	United States	94538
19	Washington Hospital	Fremont	California	United States	94538
20	Kaiser Permanente-Fresno	Fresno	California	United States	93720
21	Kaiser Permanente-Modesto	Modesto	California	United States	95356
22	Kaiser Permanente-Oakland	Oakland	California	United States	94611
23	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
24	Kaiser Permanente-Richmond	Richmond	California	United States	94801
25	Kaiser Permanente-Roseville	Roseville	California	United States	95661
26	Kaiser Permanente Downtown Commons	Sacramento	California	United States	95814
27	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
28	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
29	Salinas Valley Memorial	Salinas	California	United States	93901
30	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
31	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
32	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
33	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
34	Kaiser San Rafael-Gallinas	San Rafael	California	United States	94903
35	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
36	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
37	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
38	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
39	Kaiser Permanente-Stockton	Stockton	California	United States	95210
40	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
41	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
42	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
43	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
44	The Medical Center of Aurora	Aurora	Colorado	United States	80012
45	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
46	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
47	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
48	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
49	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
50	The Women's Imaging Center	Denver	Colorado	United States	80209
51	Porter Adventist Hospital	Denver	Colorado	United States	80210
52	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
53	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
54	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
55	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
56	Rose Medical Center	Denver	Colorado	United States	80220
57	Western Surgical Care	Denver	Colorado	United States	80220
58	Mercy Medical Center	Durango	Colorado	United States	81301
59	Southwest Oncology PC	Durango	Colorado	United States	81301
60	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
61	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
62	Swedish Medical Center	Englewood	Colorado	United States	80113
63	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
64	North Colorado Medical Center	Greeley	Colorado	United States	80631
65	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
66	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
67	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
68	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
69	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
70	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
71	Longmont United Hospital	Longmont	Colorado	United States	80501
72	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
73	McKee Medical Center	Loveland	Colorado	United States	80539
74	Parker Adventist Hospital	Parker	Colorado	United States	80138
75	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
76	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
77	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
78	Beebe Medical Center	Lewes	Delaware	United States	19958
79	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
80	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
81	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
82	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
83	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
84	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
85	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
86	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
87	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
88	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
89	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
90	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
91	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
92	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
93	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
94	Queen's Medical Center	Honolulu	Hawaii	United States	96813
95	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
96	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
97	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
98	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
99	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
100	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
101	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
102	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
103	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
104	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
105	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
106	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
107	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
108	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
109	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
110	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
111	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
112	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
113	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
114	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
115	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
116	Saint Anthony's Health	Alton	Illinois	United States	62002
117	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
118	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
119	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
120	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
121	SIH Cancer Institute	Carterville	Illinois	United States	62918
122	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
123	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
124	Jesse Brown Veterans Affairs Medical Center	Chicago	Illinois	United States	60612
125	University of Illinois	Chicago	Illinois	United States	60612
126	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
127	Carle on Vermilion	Danville	Illinois	United States	61832
128	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
129	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
130	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
131	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
132	Crossroads Cancer Center	Effingham	Illinois	United States	62401
133	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
134	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
135	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
136	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
137	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
138	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
139	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
140	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
141	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
142	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
143	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
144	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
145	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
146	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
147	Valley Radiation Oncology	Peru	Illinois	United States	61354
148	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
149	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
150	Springfield Clinic	Springfield	Illinois	United States	62702
151	Memorial Medical Center	Springfield	Illinois	United States	62781
152	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
153	Carle Cancer Center	Urbana	Illinois	United States	61801
154	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
155	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
156	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
157	Northwest Cancer Center - Main Campus	Crown Point	Indiana	United States	46307
158	Northwest Oncology LLC	Dyer	Indiana	United States	46311
159	Northwest Cancer Center - Hobart	Hobart	Indiana	United States	46342
160	Saint Mary Medical Center	Hobart	Indiana	United States	46342
161	Saint Catherine Hospital	Indianapolis	Indiana	United States	46312
162	The Community Hospital	Munster	Indiana	United States	46321
163	Women's Diagnostic Center - Munster	Munster	Indiana	United States	46321
164	Reid Health	Richmond	Indiana	United States	47374
165	Northwest Cancer Center - Valparaiso	Valparaiso	Indiana	United States	46383
166	Mary Greeley Medical Center	Ames	Iowa	United States	50010
167	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
168	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
169	Saint Anthony Regional Hospital	Carroll	Iowa	United States	51401
170	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
171	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
172	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
173	Greater Regional Medical Center	Creston	Iowa	United States	50801
174	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
175	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
176	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
177	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
178	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
179	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
180	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
181	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
182	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
183	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
184	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
185	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
186	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
187	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
188	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
189	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
190	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
191	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
192	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
193	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
194	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
195	Saint Joseph London	London	Kentucky	United States	40741
196	Jewish Hospital	Louisville	Kentucky	United States	40202
197	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
198	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
199	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
200	Walter Reed National Military Medical Center	Bethesda	Maryland	United States	20889-5600
201	Beverly Hospital	Beverly	Massachusetts	United States	01915
202	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
203	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
204	Lahey Medical Center-Peabody	Peabody	Massachusetts	United States	01960
205	Winchester Hospital	Winchester	Massachusetts	United States	01890
206	UMass Memorial Medical Center - University Campus	Worcester	Massachusetts	United States	01655
207	Hickman Cancer Center	Adrian	Michigan	United States	49221
208	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
209	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
210	Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	United States	48114
211	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
212	Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	United States	48188
213	Caro Cancer Center	Caro	Michigan	United States	48723
214	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
215	Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	United States	48118
216	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
217	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
218	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
219	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
220	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
221	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
222	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
223	Hurley Medical Center	Flint	Michigan	United States	48503
224	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
225	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
226	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
227	Sparrow Hospital	Lansing	Michigan	United States	48912
228	Hope Cancer Clinic	Livonia	Michigan	United States	48154
229	Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	United States	48154
230	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
231	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
232	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
233	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
234	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
235	Hope Cancer Center	Pontiac	Michigan	United States	48341
236	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
237	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
238	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
239	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
240	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
241	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
242	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
243	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
244	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
245	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
246	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
247	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
248	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
249	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
250	Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	United States	48197
251	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
252	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
253	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
254	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
255	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
256	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
257	Unity Hospital	Fridley	Minnesota	United States	55432
258	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
259	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
260	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
261	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
262	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
263	Health Partners Inc	Minneapolis	Minnesota	United States	55454
264	Monticello Cancer Center	Monticello	Minnesota	United States	55362
265	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
266	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
267	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
268	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
269	Regions Hospital	Saint Paul	Minnesota	United States	55101
270	United Hospital	Saint Paul	Minnesota	United States	55102
271	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
272	Lakeview Hospital	Stillwater	Minnesota	United States	55082
273	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
274	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
275	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
276	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
277	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
278	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
279	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	United States	39705
280	Baptist Cancer Center-Grenada	Grenada	Mississippi	United States	38901
281	Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	United States	38652
282	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	United States	38655
283	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
284	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
285	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
286	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
287	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
288	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
289	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
290	Freeman Health System	Joplin	Missouri	United States	64804
291	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
292	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
293	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
294	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
295	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
296	Mercy Hospital South	Saint Louis	Missouri	United States	63128
297	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
298	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
299	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
300	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
301	CoxHealth South Hospital	Springfield	Missouri	United States	65807
302	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
303	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
304	Mercy Hospital Washington	Washington	Missouri	United States	63090
305	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
306	Billings Clinic Cancer Center	Billings	Montana	United States	59101
307	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
308	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
309	Great Falls Clinic	Great Falls	Montana	United States	59405
310	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
311	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
312	Community Medical Hospital	Missoula	Montana	United States	59804
313	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
314	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
315	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
316	Cancer Partners of Nebraska - Pine Lake	Lincoln	Nebraska	United States	68516
317	Southeast Nebraska Cancer Center - 68th Street Place	Lincoln	Nebraska	United States	68516
318	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
319	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
320	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
321	Creighton University Medical Center	Omaha	Nebraska	United States	68131
322	Midlands Community Hospital	Papillion	Nebraska	United States	68046
323	Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	United States	07920
324	Monmouth Medical Center Southern Campus	Lakewood	New Jersey	United States	08701
325	Saint Barnabas Medical Center	Livingston	New Jersey	United States	07039
326	Monmouth Medical Center	Long Branch	New Jersey	United States	07740
327	Memorial Sloan Kettering Monmouth	Middletown	New Jersey	United States	07748
328	Memorial Sloan Kettering Bergen	Montvale	New Jersey	United States	07645
329	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
330	The Valley Hospital-Luckow Pavilion	Paramus	New Jersey	United States	07652
331	Neurosurgeons of New Jersey-Ridgewood	Ridgewood	New Jersey	United States	07450
332	Valley Hospital	Ridgewood	New Jersey	United States	07450
333	Valley Health System-Hematology/Oncology	Westwood	New Jersey	United States	07675
334	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
335	New Mexico Oncology Hematology Consultants	Albuquerque	New Mexico	United States	87109
336	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
337	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
338	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
339	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
340	Memorial Sloan Kettering Commack	Commack	New York	United States	11725
341	Cancer Institute at Saint Francis Hospital	East Hills	New York	United States	11548
342	Glens Falls Hospital	Glens Falls	New York	United States	12801
343	Memorial Sloan Kettering Westchester	Harrison	New York	United States	10604
344	Memorial Sloan Kettering Cancer Center	New York	New York	United States	10065
345	Upstate Cancer Center at Oneida	Oneida	New York	United States	13421
346	Upstate Cancer Center at Oswego	Oswego	New York	United States	13126
347	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
348	Memorial Sloan Kettering Nassau	Uniondale	New York	United States	11553
349	Good Samaritan Hospital Medical Center	West Islip	New York	United States	11795
350	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
351	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
352	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
353	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
354	Vidant Oncology-Kenansville	Kenansville	North Carolina	United States	28349
355	Novant Health Cancer Institute - Kernersville	Kernersville	North Carolina	United States	27284
356	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
357	Novant Health Cancer Institute - Mount Airy	Mount Airy	North Carolina	United States	27030
358	Vidant Oncology-Richlands	Richlands	North Carolina	United States	28574
359	Novant Health Cancer Institute - Statesville	Statesville	North Carolina	United States	28625
360	Novant Health Cancer Institute - Thomasville	Thomasville	North Carolina	United States	27360
361	Novant Health Cancer Institute - Wilkesboro	Wilkesboro	North Carolina	United States	28659
362	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
363	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
364	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
365	Southpointe-Sanford Medical Center Fargo	Fargo	North Dakota	United States	58103
366	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
367	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
368	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
369	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
370	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
371	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
372	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
373	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
374	Miami Valley Hospital South	Centerville	Ohio	United States	45459
375	Geauga Hospital	Chardon	Ohio	United States	44024
376	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
377	University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	United States	45219
378	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
379	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
380	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
381	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
382	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
383	Case Western Reserve University	Cleveland	Ohio	United States	44106
384	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
385	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
386	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
387	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
388	Grant Medical Center	Columbus	Ohio	United States	43215
389	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
390	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
391	Doctors Hospital	Columbus	Ohio	United States	43228
392	Miami Valley Hospital	Dayton	Ohio	United States	45409
393	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
394	Miami Valley Hospital North	Dayton	Ohio	United States	45415
395	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
396	Grady Memorial Hospital	Delaware	Ohio	United States	43015
397	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
398	Armes Family Cancer Center	Findlay	Ohio	United States	45840
399	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
400	Orion Cancer Care	Findlay	Ohio	United States	45840
401	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
402	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
403	Central Ohio Breast and Endocrine Surgery	Gahanna	Ohio	United States	43230
404	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
405	Wayne Hospital	Greenville	Ohio	United States	45331
406	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
407	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
408	Kettering Medical Center	Kettering	Ohio	United States	45429
409	Fairfield Medical Center	Lancaster	Ohio	United States	43130
410	Saint Rita's Medical Center	Lima	Ohio	United States	45801
411	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
412	Cleveland Clinic Cancer Center Mansfield	Mansfield	Ohio	United States	44906
413	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
414	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
415	Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	United States	44124
416	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
417	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
418	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
419	Licking Memorial Hospital	Newark	Ohio	United States	43055
420	Newark Radiation Oncology	Newark	Ohio	United States	43055
421	University Hospitals Parma Medical Center	Parma	Ohio	United States	44129
422	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
423	UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
424	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
425	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
426	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
427	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
428	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
429	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
430	Upper Valley Medical Center	Troy	Ohio	United States	45373
431	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
432	South Pointe Hospital	Warrensville Heights	Ohio	United States	44122
433	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
434	University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	United States	45069
435	Saint Ann's Hospital	Westerville	Ohio	United States	43081
436	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
437	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
438	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
439	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
440	Integris Southwest Medical Center	Oklahoma City	Oklahoma	United States	73109
441	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
442	Integris Cancer Institute of Oklahoma	Oklahoma City	Oklahoma	United States	73142
443	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
444	Saint Charles Health System	Bend	Oregon	United States	97701
445	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
446	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
447	Bay Area Hospital	Coos Bay	Oregon	United States	97420
448	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
449	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
450	Providence Portland Medical Center	Portland	Oregon	United States	97213
451	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
452	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
453	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
454	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
455	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
456	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
457	Chambersburg Hospital	Chambersburg	Pennsylvania	United States	17201
458	WellSpan Medical Oncology and Hematology	Chambersburg	Pennsylvania	United States	17201
459	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
460	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
461	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
462	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
463	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
464	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
465	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
466	Sechler Family Cancer Center	Lebanon	Pennsylvania	United States	17042
467	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
468	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
469	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
470	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
471	Cancer Care Associates of York	York	Pennsylvania	United States	17403
472	WellSpan Health-York Cancer Center	York	Pennsylvania	United States	17403
473	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
474	Medical University of South Carolina	Charleston	South Carolina	United States	29425
475	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
476	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
477	Baptist Memorial Hospital and Cancer Center-Collierville	Collierville	Tennessee	United States	38017
478	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
479	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
480	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
481	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
482	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
483	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
484	Harrison Medical Center	Bremerton	Washington	United States	98310
485	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
486	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
487	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
488	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
489	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
490	Saint Francis Hospital	Federal Way	Washington	United States	98003
491	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
492	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
493	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
494	Saint Clare Hospital	Lakewood	Washington	United States	98499
495	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
496	Jefferson Healthcare	Port Townsend	Washington	United States	98368
497	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
498	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
499	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
500	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
501	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
502	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
503	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
504	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
505	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
506	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
507	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
508	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
509	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
510	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
511	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
512	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
513	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
514	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
515	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
516	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
517	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
518	Billings Clinic-Cody	Cody	Wyoming	United States	82414
519	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Helena A Yu, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT04181060
• Other Study ID Numbers: NCI-2019-07941; NCI-2019-07941; EA5182; EA5182; U10CA180820
• First Posted: Nov 29, 2019
• Last Update Posted: Aug 24, 2022
• Last Verified: Jun 1, 2022

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Bevacizumab; Antineoplastic Agents, Immunological; Osimertinib; Endothelial Growth Factors; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G

Study Results

No Results Posted as of Aug 24, 2022