Evaluation of the Advantage in the Use of Enteral Nutrition in Children Treated for Acute Lymphoblastic Leukemia
Study Details
Study Description
Brief Summary
This is a multicenter retrospective study (Reims and Nancy), with data collection over 12 years from 01/01/2010 to 12/31/2022 Patients included are children diagnosed with acute lymphoblastic leukemia between 2010 and 2021 in the 2 centers.
Patients will be categorized into 3 groups:
-
No nutritional support
-
Support by enteral nutrition
-
Parenteral nutrition support Their nutritional status will be assessed at the end of induction, at 6 months and then at 12 months from diagnosis.
The main objective of this study is therefore to compare the nutritional status of children with acute lymphoblastic leukemia depending on whether they received enteral or parenteral nutritional support during their treatment.
The secondary objective is to evaluate the occurrence of complications during treatment according to the nutritional support received.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| enteral nutrition children who received enteral nutritional support during treatment |
Dietary Supplement: enteral or parenteral nutritional support
Parents will be classified based on whether they received enteral or parenteral nutritional support during treatment.
|
| parenteral nutrition children who received parenteral nutritional support during treatment |
Dietary Supplement: enteral or parenteral nutritional support
Parents will be classified based on whether they received enteral or parenteral nutritional support during treatment.
|
Outcome Measures
Primary Outcome Measures
- Z-score [6 months]
Compare the improvement in Z-score between the date of diagnosis and 6 months from diagnosis in children using parenteral nutrition and those using enteral nutrition during treatment of their acute lymphoblastic leukemia
Secondary Outcome Measures
- BMI [6 months]
Compare the improvement in BMI between the date of diagnosis and 6 months from diagnosis in children using parenteral nutrition and those using enteral nutrition during treatment of their acute lymphoblastic leukemia
- albumin [6 months]
Compare the improvement in albumin level between the date of diagnosis and 6 months from diagnosis in children using parenteral nutrition and those using enteral nutrition during treatment of their acute lymphoblastic leukemia
- complications [1 year]
Compare the percentages of occurrence of complications between the date of diagnosis and 6 months after diagnosis in children using parenteral nutrition and those using enteral nutrition during treatment for their acute lymphoblastic leukemia
Eligibility Criteria
Criteria
Inclusion Criteria:
- Children between 1 and 18 years old diagnosed with Medium risk/ High Risk B acute lymphoblastic leukemia or Standard/ High Risk T acute lymphoblastic leukemia between 2010 and 2021 in Nancy and Reims.
Exclusion Criteria:
-
Patients less than 1 year old
-
leukémia with philadelphia chromosome
-
standard risk B acute lymphoblastic leukemia
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bone marrow transplant during treatment
-
death during the year following diagnosis
-
refusal of the patient (parents) to participate in the study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHRU Nancy | Vandœuvre-lès-Nancy | France | 54500 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2023_PI_069