E-Mechanic_Fol: Effects of Aerobic Exercise Detraining

Sponsor

Pennington Biomedical Research Center (Other)

Overall Status

Completed

CT.gov ID

NCT02158130

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The proposed study seeks to better understand the role of body weight, energy expenditure, and energy intake as mechanisms of body weight gain during detraining following aerobic exercise. It is hypothesized that participants in the higher dose exercise group will have greater body weight gain compared to the lower exercise dose and control group from wk 24 to wk 76 follow-up.

Condition or Disease	Intervention/Treatment	Phase
Motor Activity Body Weight Obesity

Detailed Description

Eligibility criteria include having successfully completed the main E-Mechanic study, be willing to archive blood samples and not being currently enrolled in another study that may effect body, energy intake or energy expenditure. The investigators will measure body weight, waist/hip circumference, blood pressure, body composition, physical activity, questionnaire about appetite/food intake and physical fitness.

Study Design

Study Type:

Observational

Actual Enrollment :

25 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Effects of Aerobic Exercise Detraining on Energy Balance in Overweight Persons

Study Start Date :

Sep 1, 2014

Actual Primary Completion Date :

Mar 1, 2016

Actual Study Completion Date :

Mar 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Healthy Living non exercise healthy living control group
General Health Exercise Group (8 KKW) One exercise group will obtain 8KKW (kcal/kg/week) over 3-4 sessions per week, which will result in each session lasting approximately 30 minutes. We will recruit 1 year post study intervention.
Weight Loss Exercise Group (20 KKW) Exercise group will obtain 20 KKW, perform in 4-5 sessions per week for approximately 50-70 minutes per session. We will recruit 1 year post study intervention.

Outcome Measures

Primary Outcome Measures

Body Weight [Week 64 - 88 post study randomization]
Fasting body weight

Secondary Outcome Measures

Energy Expenditure [Week 64 - 90 since study randomization]
Energy expenditure is calculated with the Sensewear Armband.
Energy Intake [Week 64 - 90 post study randomization]
Energy expenditure is calculated with the Sensewear Armband and furthermore, energy intake is calculated by adjusting TDEE for change in body weight following the methods used in doubly labeled water adjustment.

Other Outcome Measures

Circumferences [Week 64-88 post study randomization]
Waist and hip circumferences
Blood Pressure [Week 64-88 post study randomization]
Body Composition [Week 64 - 88 post study randomization]
Whole Body Scan GE iDXA (Dual energy x-ray absorptiometry)
Triglycerides [Week 64 - 88 post study randomization]
Cholesterol [Week 64 - 88 post study randomization]
Total, HDL, and LDL cholesterol

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 67 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Completed the E-Mechanic study
Be willing to archive blood samples
Not participating in a study that would alter body weight, energy intake, or energy expenditure.