Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness
Study Details
Study Description
Brief Summary
In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects and patients with dry eye syndrome. Patients with dry eye syndrome and subjects with a healthy ocular surface will be enrolled. All participant will underwent LLT measurement with a LipiView interferometer, tear meniscus height measurement using optical coherence tomography, tear film break-up time (TBUT) determination, corneal and conjunctival staining, Schirmer's test, examination of the lid margins and meibomian glands, and assessment using the Ocular Surface Disease Index(OSDI) questionnaire.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Dry eye Patients with dry eye syndrome |
|
| normal Patients without dry eye |
Outcome Measures
Primary Outcome Measures
- Tear Lipid Layer thickness measurement with a LipiView interferometer [1 day]
Secondary Outcome Measures
- tear meniscus height measurement using optical coherence tomography [1 day]
- Corneal and conjunctival erosion grade(oxford score) [1 day]
- tear film break-up time (TBUT) [1 day]
- Schirmer's test (lacrimal secretion test) [1 day]
- evaluation of the score of lid margins and meibomian glands [1 day]
- Ocular Surface Disease Index(OSDI) questionnaire [1 day]
Eligibility Criteria
Criteria
Inclusion Criteria:
- age over 19 years old, Patients with dry eye syndrome and normal subjects
Exclusion Criteria:
-
patients less than 18 years of age and patients with histories of ocular surgery within 3 months; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease; and patients with the use of a punctal plug or topical ocular medications other than artificial tears.
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Patients who used artificial tears were instructed not to apply them for at least 12 hours 99 before the examinations
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Ophthalmology, Yonsei Univeristy College of Medicine | Seoul | Korea, Republic of | 03722 |
Sponsors and Collaborators
- Yonsei University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Hom MM, Martinson JR, Knapp LL, Paugh JR. Prevalence of Meibomian gland dysfunction. Optom Vis Sci. 1990 Sep;67(9):710-2.
- Knop E, Knop N, Millar T, Obata H, Sullivan DA. The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):1938-78. doi: 10.1167/iovs.10-6997c. Print 2011 Mar. Review.
- McCulley JP, Shine WE. The lipid layer of tears: dependent on meibomian gland function. Exp Eye Res. 2004 Mar;78(3):361-5. Review.
- Tomlinson A, Bron AJ, Korb DR, Amano S, Paugh JR, Pearce EI, Yee R, Yokoi N, Arita R, Dogru M. The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):2006-49. doi: 10.1167/iovs.10-6997f. Print 2011 Mar. Review.
- 4-2015-1009