Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Sponsor

Rudolf Foundation Clinic (Other)

Overall Status

Unknown status

CT.gov ID

NCT00533754

Collaborator

(none)

Location

Duration (Months)

Study Details

Study Description

Brief Summary

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.

Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.

Condition or Disease	Intervention/Treatment	Phase
Age-Related Macular Degeneration	Procedure: drawing blood	N/A

Study Design

Study Type:

Interventional

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

Single (Outcomes Assessor)

Primary Purpose:

Basic Science

Official Title:

Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Study Start Date :

Jul 1, 2006

Anticipated Study Completion Date :

Nov 1, 2007

Outcome Measures

Primary Outcome Measures

higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals []

Secondary Outcome Measures

a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD []

Eligibility Criteria

Criteria

Ages Eligible for Study:

55 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

man and women over 18 years old
Filled out informed consentBereitschaft zur Teilnahme
Diagnosis of non-exudative/ exudative age related macular dgeneneration

Exclusion Criteria:

inherited retinal diseases
other aquired retinal/ macular
missing informed consent

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Rudoulf foundation Clinic	Vienna		Austria	1030

Sponsors and Collaborators

Rudolf Foundation Clinic

Investigators

Study Chair: Susanne Binder, M.D., Rudoulf Foundation Clinic

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT00533754

Other Study ID Numbers:

EK 06-076-VK
EK 06-076-VK

First Posted:

Sep 21, 2007

Last Update Posted:

Sep 21, 2007

Last Verified:

Sep 1, 2007

Keywords provided by , ,

Additional relevant MeSH terms:

Macular Degeneration

Study Results

No Results Posted as of Sep 21, 2007