Agility Training on Executive Function, Dual Task Performance and Brain Activation in Healthy Adults
Study Details
Study Description
Brief Summary
This study will investigate the effect of agility training on executive function, dual task walking and brain activation in healthy adults. Participants (N=70) will be randomly assigned to resistance+aerobic training group (RAeT) or agility training group (AT). Participants in RAeT (n=35) will receive 15-minute lower extremity workout first and then 25-minute moderate intensity (60-75% predicted maximal heart rate) aerobic training. Participants in AT (n=35) will do the agility exercise program consisting of technical drills, pattern running and reactive agility training. The intervention will be twelve-time group intervention (3-5persons) in four weeks, 50 minutes per session (5-minute warmup, 40- minute main training, 5-minute cool-down). Participants will undergo three measurement time points (pre-, post-intervention and one month follow-up). Outcome measures will include executive function (N-back test, stroop test and Wisconsin card sort test), single and dual task walking performance and brain activity (fNIRS on prefrontal cortex, supplementary motor area and premotor cortex). Two-way analysis of variance (ANOVA) with Tukey post-hoc test will be used to examine the group x time interaction on three outcome measures.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Resistance+Aerobic training group Resistance+Aerobic training group (RAeT) RAeT includes resistance training (RT) program and aerobic training (AeT) program. |
Other: Resistance+Aerobic training
The RT focuses on lower extremity workout, including leg press, hamstring curls, and calf raises. The participants start with intensity at 12 RM and finished with intensity at 8 RM after 3 weeks. There are 8 repetitions, 2 sets for each action. It will take 15 minutes to complete RT.
The AeT is composed by cycling on stationary bikes in the first week, stepping on steppers in 2nd week, and running on treadmills in the last week. Participants are asked to wear a portable heart rate monitor throughout the experiments. They have to maintain their heart rates in 60%-75% of predicted maximal heart rate (moderate intensity exercise), which has been shown to be benefit on cognition[3]. It took the participants 25 minutes to complete AeT.
Other Names:
|
| Experimental: Agility training group Agility training |
Other: Agility training
AT program consists of three parts: technical drills, pattern running and reactive agility training. There will be nine sessions over 3 weeks and progress the intensity, complexity or velocity every week.
Other Names:
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Outcome Measures
Primary Outcome Measures
- Executive function- N-back task (3-back) [Change from Baseline score at 3 weeks]
N-back task (3-back) is used to measure working memory
- Executive function- N-back task (3-back) [Change from Baseline score at 7 weeks]
N-back task (3-back) is used to measure working memory
- Executive function- Stroop test [Change from Baseline score at 3 weeks]
Stroop test is used to measure the selective attention and conflict resolution.
- Executive function- Stroop test [Change from Baseline score at 7 weeks]
Stroop test is used to measure the selective attention and conflict resolution.
- Executive function- Wisconsin card sort test [Change from Baseline score at 3 weeks]
Wisconsin card sort test is an easy way to assess the ability of mental set shifting.
- Executive function- Wisconsin card sort test [Change from Baseline score at 7 weeks]
Wisconsin card sort test is an easy way to assess the ability of mental set shifting.
- Single walking performance- Walking speed [Change from Baseline cadence at 3 weeks]
The unit is length (cm) per seconds
- Single walking performance- Walking speed [Change from Baseline cadence at 7 weeks]
The unit is length (cm) per seconds
- Single walking performance- Cadence [Change from Baseline cadence at 3 weeks]
The unit is steps per minutes
- Single walking performance- Cadence [Change from Baseline cadence at 7 weeks]
The unit is steps per minutes
- Single walking performance- Stride length [Change from Baseline cadence at 3 weeks]
The unit is cm
- Single walking performance- Stride length [Change from Baseline cadence at 7 weeks]
The unit is cm
- Single walking performance- Step duration [Change from Baseline cadence at 3 weeks]
The unit is seconds
- Single walking performance- Step duration [Change from Baseline cadence at 7 weeks]
The unit is seconds
- Dual task walking performance- Walking speed [Change from Baseline cadence at 3 weeks]
The unit is length (cm) per seconds
- Dual task walking performance- Walking speed [Change from Baseline cadence at 7 weeks]
The unit is length (cm) per seconds
- Dual task walking performance- Cadence [Change from Baseline cadence at 3 weeks]
The unit is steps per minutes
- Dual task walking performance- Cadence [Change from Baseline cadence at 7 weeks]
The unit is steps per minutes
- Dual task walking performance- Stride length [Change from Baseline cadence at 3 weeks]
The unit is cm
- Dual task walking performance- Stride length [Change from Baseline cadence at 7 weeks]
The unit is cm
- Dual task walking performance- Step duration [Change from Baseline cadence at 3 weeks]
The unit is seconds
- Dual task walking performance- Step duration [Change from Baseline cadence at 7 weeks]
The unit is seconds
- Dual task walking performance- the correct rates of arithmetic task [Change from Baseline cadence at 3 weeks]
The participants will be instructed to subtract by 7 serially from a 3-digit number while walking at their fastest speed in dual task walking condition
- Dual task walking performance- the correct rates of arithmetic task [Change from Baseline cadence at 7 weeks]
The participants will be instructed to subtract by 7 serially from a 3-digit number while walking at their fastest speed in dual task walking condition
Secondary Outcome Measures
- Brain activities over premotor cortex- Executive function [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over premotor cortex- Executive function [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Executive function [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Executive function [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex- Executive function [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex- Executive function [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over premotor cortex- Single walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over premotor cortex- Single walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Single walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Single walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex - Single walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex - Single walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over premotor cortex- Dual task walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over premotor cortex- Dual task walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Dual task walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over supplementary motor area- Dual task walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex - Dual task walking [Change from Baseline at 3 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
- Brain activities over primary motor cortex - Dual task walking [Change from Baseline at 7 weeks]
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Eligibility Criteria
Criteria
Inclusion Criteria:
- (1) age between 20 to 30 years, and (2) ability to walk 20 meters independently without an assistive device.
Exclusion Criteria:
- (1) overweight (BMI>24), (2) any smoker or alcohol abusers, (3) suffering from chronic diseases that loss of control, (4) Unstable physiological conditions, such as abnormal signs like high blood pressure, headache, dyspnea, fever, etc., (5) any neuromuscular or cardiopulmonary diseases that would influent the exercise performance, and (6) suffering from diseases which exercises are their contraindications
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Taiwan University Hospital | Taipei | Taiwan |
Sponsors and Collaborators
- National Taiwan University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 202103055RINB