The Impact of a Fast Diet and Calorie Mimetic Supplements on Epigenetic Aging
Study Details
Study Description
Brief Summary
This is a prospective randomized clinical study of 50 patients to evaluate the fasting mimicking diet program by Prolon with a calorie mimetic supplement from Peak Human Labs. This study will be evaluating the effectiveness of the combined intervention over a three month program.
The study will assess the effects that the program has on the participants' biological aging.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Fasting Mimicking Diet + Supplement / Usual Routine Participants in will be asked to begin the Peak Human Labs calorie mimetic supplement. They will also begin on day 1 the 5 day Fasting Mimicking Diet Program. Participants will continue the supplementation for the 90 days and repeat the 5 day Fasting Mimicking Diet Program on days 1, 29 and 57. Starting at day 91, they will return to their usual daily routine. |
Dietary Supplement: Peak Human Labs calorie mimetic supplement
Supplement
Behavioral: Fasting Mimicking Diet
Diet
|
| Experimental: Supplement / Usual Routine Participants will be asked to begin the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days. Starting at day 91, they will return to their usual daily routine. |
Dietary Supplement: Peak Human Labs calorie mimetic supplement
Supplement
|
| Experimental: Usual Routine / Fasting Mimicking Diet + Supplement Participants will have no intervention for the first 90 days, during which they will be asked not to start a new fasting program supplement. At day 91, they will begin the 5-day Fasting Mimicking Diet Program and start the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days and repeat the 5-day Fasting Mimicking Diet Program on days 91, 120, and 148. |
Dietary Supplement: Peak Human Labs calorie mimetic supplement
Supplement
Behavioral: Fasting Mimicking Diet
Diet
|
| Experimental: Usual Routine / Supplement Participants will have no intervention for the first 90 days, during which they will be asked not to start a new fasting program supplement. At day 91,start the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days. |
Dietary Supplement: Peak Human Labs calorie mimetic supplement
Supplement
|
Outcome Measures
Primary Outcome Measures
- Epigenetic Age Biomarkers [Change from baseline to 3 months]
Outcome epigenetic age testing will test methylation at 850,000 spots on the DNA/
- Epigenetic Age Biomarkers [Change from baseline to 6 months]
Outcome epigenetic age testing will test methylation at 850,000 spots on the DNA/
Secondary Outcome Measures
- Body Mass Index [Change from baseline to 6 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Healthy individuals
-
Age > 16 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Peak Human Labs | Brampton | Ontario | Canada | L6W 3E1 |
Sponsors and Collaborators
- TruDiagnostic
- L-Nutra Inc
- Peak Human Labs
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28.
- Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.
- Chen J, Li Y, Zhu Q, Li T, Lu H, Wei N, Huang Y, Shi R, Ma X, Wang X, Sheng J. Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d-Galactose. Mech Ageing Dev. 2017 Jun;164:1-7. doi: 10.1016/j.mad.2017.03.007. Epub 2017 Mar 24.
- TD-EA-001