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EPC-Ex: Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Sponsor
Baltimore VA Medical Center (U.S. Fed)
Overall Status
Active, not recruiting
CT.gov ID
NCT01169831
Collaborator
University of Maryland, Baltimore (Other), University of Maryland, College Park (Other)
60
Enrollment
1
Location
2
Arms
138
Duration (Months)
0.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Condition or Disease Intervention/Treatment Phase
  • Other: Exercise Training
  • Other: Exercise Cessation
 N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
60 participants
Allocation:
Non-Randomized
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Study Start Date :
Jul 1, 2011
Actual Primary Completion Date :
Nov 1, 2014
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Experimental: Sedentary Older Adults

Other: Exercise Training
2 weeks of daily aerobic exercise training
Experimental: Older Endurance Athletes

Other: Exercise Cessation
Stopping all exercise for 2 weeks

Outcome Measures

Primary Outcome Measures

  1. Baseline Endothelial progenitor cell number [Day 1]

  2. Final Endothelial Progenitor Cell Number [Day 15]

Secondary Outcome Measures

  1. Baseline Endothelial Reactivity [Day 1]

  2. Final Endothelial Reactivity [Day 15]

Eligibility Criteria

Criteria

Ages Eligible for Study:
50 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal
Exclusion Criteria:
  • history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

Contacts and Locations

Locations

Site City State Country Postal Code
1 University of Maryland, Baltimore & Baltimore VA Medical Center Baltimore Maryland United States 21201

Sponsors and Collaborators

  • Baltimore VA Medical Center
  • University of Maryland, Baltimore
  • University of Maryland, College Park

Investigators

  • Principal Investigator: Steven J Prior, Ph.D., University of Maryland, Baltimore

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
Steven J. Prior, Ph.D., Assistant Professor, University of Maryland, Baltimore
ClinicalTrials.gov Identifier:
NCT01169831
Other Study ID Numbers:
  • HP-00045413
First Posted:
Jul 26, 2010
Last Update Posted:
Mar 15, 2022
Last Verified:
Feb 1, 2022
Additional relevant MeSH terms:
Cardiovascular Diseases

Study Results

No Results Posted as of Mar 15, 2022