ACTIFS-AGE: Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
Study Details
Study Description
Brief Summary
There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Young, Active group From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
| Active Comparator: Young, sedentary group From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
| Active Comparator: Old, Active group From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
| Active Comparator: Old sedentary group From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
| Active Comparator: Very old, Active group From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
| Active Comparator: Very old sedentary group From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years. |
Other: Questionnaires completion
Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.
Other: Isometric forces
Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.
Other: Energy cost
Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.
|
Outcome Measures
Primary Outcome Measures
- Maximal voluntary contraction (MVC) of the knee extensor muscle measurement [At 48 hours]
Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
Secondary Outcome Measures
- Voluntary activation measurement (%) [At 48 hours]
The level of voluntary activation will be determined by the force increment obtained following stimulation performed during a condition of the muscle in a state of maximum contraction.
- Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement [At 48 hours]
Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
- Maximal voluntary contraction (MVC) of the hand grip measurement [At 48 hours]
Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
- Cardiac variability(ms) [At 48 hours]
24-hour measurement with an ECG holter for 24 hours.
- Muscle oxygenation (%) [At 48 hours]
This is measured by a NIRS20 (near infrared spectroscopy, Oxysoft, Artinis, TheNetherlands)
- Balance test (s) [At 48 hours]
This test, performed in unipedal support, consists of asking the subject to hold the unipedal position for as long as possible, on the lower limb of his choice.
- Test of Get-up-and-Go (s) [At 48 hours]
For test of Get-up-and-Go, participants will be asked to stand from a seated position, walk 3 meters at their usual pace, turn around, walk back to the chair, and sit down. Measured in seconds when performing test.
- Reaction force on the ground for each step (N) [At 72 hours]
First, a maximum pace walking speed and a comfort speed will be measured in a corridor using photoelectric cells. Then, a biomechanical analysis of walking at several speeds (comfort walking, 2.5, 4 and 5.5 km/h) will be performed on an instrumented treadmill (Treadmetrix, Park City, Utah, United States). This treadmill allows the analysis of the reaction forces on the ground during the strides while controlling the speed of the walk. Each step will last approximately 30 seconds.
- Maximal oxygen consumption (VO2max) during an effort test on a cycloergometer [At 72 hours]
- Functional Assessment of Chronic Illness Therapy (FACIT) questionnaire [At inclusion]
Score from 0 to 52
- Quality of life via the SF-36 questionnaire [At inclusion]
This questionnaire is composed of 12 questions representing the eight most relevant domains to describe and evaluate quality of life. Score ranges from 0 to 100, with a higher score defining a more favorable health state.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
-
Signed consent for the study obtained
-
Subject affiliated or entitled to a social security scheme
Exclusion Criteria:
-
Pathology or surgical intervention causing a locomotor disorder
-
Neurological, cardiovascular or psychological pathology
-
Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
-
Mini-Mental State Examination score < 20 (>80 years old)
-
Significant change in the amount of physical practice over the last 5 years.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chu de Saint-Etienne | Saint-Étienne | France | 42055 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Saint Etienne
Investigators
- Principal Investigator: LEONARD FEASSON, PHD, Centre Hospitalier Universitaire de Saint Etienne
- Study Chair: Guillaume MILLET, PhD, UNIVERSITE DE SAINT ETIENNE
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 21CH033
- ANSM